Advances in technology and computational power opened the doors to dissecting human genomic datasets and understanding the complex genetic interactions underlying disease. In this episode, Dr. Manolis Kellis discusses his recent paper with Dr. Tsai analyzing the transcriptomes of 48 postmortem Alzheimer’s Disease brain samples. Dr. Kellis is a Professor of Computer Science at MIT, the head of the MIT Computational Biology Group, the principal investigator of CSAIL (Computer Science and Artificial Intelligence Lab), and an Institute Member at the Broad Institute.