Can your gut control your lifespan? What if molecules produced by your microbiome could prevent obesity, Alzheimer’s, and inflammation, just by supporting the right immune response?

In this episode of The Augmented Life, Michael Tiffany sits down with Dr. Dan Winer and Nicholas Tubach, the team behind Propion, a new science-backed startup exploring the frontier of postbiotics, specifically indole metabolites like indole-3-propionic acid (IPA). Dr. Winer unpacks how decades of immunometabolism research led him to the gut-liver-brain axis, and how he and Nicholas translated that science into a product aimed at improving healthspan, not just lifespan.

We cover:• The role of adaptive immune cells in obesity• How the gut barrier protects (or harms) other organs• What postbiotics like IPA actually do• How Propion went from gaming chat to startup launchWhy your microbiome might be aging you faster than you think—

⏱️ Timestamps

0:00 – Intro

1:00 – How video games led to an obesity discovery

2:45 – T cells, B cells, and metabolic disease

4:30 – Why fat is downstream of gut inflammation

6:00 – From gut to liver to brain: the immune system’s travel map

8:30 – What is “meta-inflammation” and how it links to aging

10:30 – The top environmental drivers of aging

13:00 – Prebiotics, probiotics, postbiotics: what’s the difference?

14:30 – How short-chain fatty acids modulate the immune system

16:00 – Discovering indole-3-propionic acid (IPA)

18:00 – The neuroscience link: Alzheimer's and indoles

20:00 – Why Propion chose to go prebiotic first

24:00 – How tryptophan gets converted by gut bacteria

28:00 – Fixing leaky gut and insulin resistance at the root

32:00 – Gut-derived immune cells can end up in the brain

34:30 – Could a virus or gut bug be triggering autoimmune disease?

38:00 – Building Propion: from molecule to market

42:00 – Why prebiotics may be safer (and more scalable)

47:00 – Citizen science + tracking metrics = product evolution

53:00 – What’s next: GLP-1, sarcopenia, and custom formulations

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#immunometabolism #guthealth #postbiotics #propion #agingresearch #longevity #indolemetabolites #microbiome #Alzheimers #obesity #TheAugmentedLife

Why do some people crush their goals effortlessly while others stall out—even with the same advice?

In this episode of The Augmented Life, Michael Tiffany sits down with bestselling author and behavior science expert Gretchen Rubin to unpack what actually drives habit change, happiness, and self-awareness and why cookie-cutter strategies so often fail.

They explore the hidden power of sensory experience, how to avoid the trap of over-optimization, and why personality frameworks like the Four Tendencies might hold the key to finally making change stick.

Whether you're a startup founder, productivity hacker, or just trying to live more intentionally, this is a conversation that cuts through the noise with real insights and practical tools you can use immediately.

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⏱️ Timestamps

0:00 – Intro

1:36 – Writing with restraint: aphorisms & clarity

4:08 – Reductive vs. enriching measurement

6:22 – Self-tracking vs. actual self-awareness

10:27 – Why Gretchen doesn’t chase word counts

12:10 – Is Gretchen Rubin a hacker? (Yes.)

17:18 – The Four Tendencies explained

24:25 – Quiz data & personality distributions

28:14 – Why “just do it” doesn’t work for everyone

30:39 – Gretchen’s sweet tooth & giving up sugar

34:30 – When clarity = willpower for Questioners

36:20 – Why Rebels hate to-do lists (and what to do instead)

41:16 – 25-for-25: Habit design meets fun

44:40 – Awe, embodiment, and recovering from disconnection

46:32 – What’s your most neglected sense?

48:25 – From intellectual meditation to embodied awareness

51:26 – Feelings are data (and evolution knew it first)

53:17 – Where to find Gretchen’s quizzes, books & tools

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#happinesshabits #thefourtendencies #gretchenrubin #behaviorchange #productivity #personalitytypes #theaugmentedlife #selfknowledge #selfoptimization

In this episode of The Augmented Life, Michael Tiffany sits down with Adam Greenfeld, Co-Founder at Thesis Nootropics.

They unpack the science and strategy behind brain enhancement, from the early Reddit-fueled experiments that shaped Thesis, to the surprising audiences using nootropics today.

Adam opens up about dopamine burnout, self-experimentation, how he evaluates if a stack is working, and why optimizing for "life experience" now beats waiting for a big exit.

Whether you're deep into biohacking or just curious how to improve task switching and mental clarity, this conversation blends rigorous science, personal reflection, and practical strategies you can use today.

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⏱️ Timestamps

00:00 – Welcome to The Augmented Life

01:09 – How do you pronounce "nootropics"?

02:57 – Science vs. woo: intuition as real data

04:38 – Adam’s seasonal approach to objectivity vs. energy

05:45 – Stress, inflammation, and felt results

08:05 – The limits of pharmaceutical science vs. biohacking

10:02 – The original Thesis testing protocol: 2,500 participants

13:26 – 130+ ingredients tested, 85% match accuracy

16:26 – Why being non-precious with formulations worked

18:23 – Innovation vs validation in supplement design

19:39 – From biohackers to SoulCycle execs: Who uses Thesis

22:48 – The “busy mother” demographic and shifting audiences

24:11 – Adam’s nuanced POV on Adderall over prescription

26:36 – Why Stasis is for people staying on Adderall

27:50 – The dopamine receptor burnout theory

29:05 – The real addiction: stress and complexity

31:17 – Daily stack: creatine, clomiphene, magnesium, clean eating

36:34 – Hydrogen tablets, walking, ocean therapy, and woo

38:40 – Still taking Thesis: 7 years, 5 days a week

40:10 – Optimize for life experience, not just exit strategy

43:28 – How to measure if nootropics work

45:51 – Sub-perceptual vs. felt effects: a product design insight

47:27 – Task switching speed: a killer metric for high performers

48:22 – Where to find Adam + links to Thesis & Stasis

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#nootropics #biohacking #dopamine #thesisnootropics #selfoptimization #adderralsupport #augmentedlife #brainhealth #creatine #taskswitching #founderstory #mentalperformance #takethesis #takestasis #adamgreenfeld

Is your health routine actually making you healthier, or just making you more anxious?

In this episode of The Augmented Life, Michael Tiffany sits down with biohacker and longevity expert Nathalie Niddam to unpack the line between meaningful health optimization and counterproductive obsession.

They dive deep into practical longevity, the role of hormones, light, genetics, wearables, and even peptides, starting with what really matters: How you feel, how you live, and whether you’ve nailed the basics.

Nathalie offers a grounded, systems-thinking approach to health: Test intelligently, live in sync with light and circadian rhythms, move naturally, and don’t skip the fundamentals in your rush to "biohack" your way to 100.

This conversation is for anyone who’s trying to balance data with intuition, modern tech with ancestral wisdom, and optimization with actually enjoying life.

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⏱️ Timestamps

00:00 – Intro: Optimization vs over-optimization

01:00 – Why chasing data can backfire on your wellness

04:00 – Foundational health vs fancy interventions

06:30 – How to know if you're actually thriving

09:00 – Light as a missing piece of the wellness puzzle

12:00 – Circadian biology, vitamin D, and UVB tech

15:00 – Behavioral change vs jumping to TRT

18:00 – The role of strength training in longevity

21:00 – Labs that actually matter (and what they tell you)

23:00 – Why most people are taking the wrong supplements

24:30 – Biological age tests and what to do with the data

28:00 – HRV: Overrated, misunderstood, or useful?

32:00 – The value of tuning in before you tune your metrics

35:00 – Genetics as lifestyle feedback, not destiny

39:00 – Living well with APOE4 and other gene variants

42:00 – Why the foundations still matter more than any one

hack

44:00 – Peptides, testing, and when to actually start

46:00 – Final advice: Direction > perfection

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#longevity #biohacking #healthoptimization #nathalieniddam #peptides #HRV #epigenetics #circadianhealth #theaugmentedlife #healthspan #lifespan

What happens when millions of people take health into their own hands?In this episode of The Augmented Life, Michael Tiffany sits down with Shelby Newsad, biohacker, investor, and principal author of A Biohacker Future, to explore the explosive intersection of AI, gene therapy, neuromodulation, and self-experimentation.Shelby shares what inspired her to write one of the most ambitious pieces of biotech futurism to date—and why she believes biohacking is not just a fringe movement, but a full-blown social shift toward radical individual empowerment.Topics include:• The rise of the biohacker of necessity• The future of follistatin gene therapy and muscle enhancement• Ultrasonic neuromodulation and the fast-tracking of meditation mastery• How ChatGPT is changing the doctor-patient power dynamic• The role of AI therapy, context-aware LLMs, and digital self-understanding• Why optimism may actually be a sign of higher intelligenceThis episode is a deep, exploratory ride through what’s possible when curiosity meets capability, and why the next wave of biotech innovation might start with you.

Would you outsource your memory if it made you a better friend, parent, or leader?

In this mind-expanding episode of The Augmented Life, Michael Tiffany sits down with Dan Siroker—co-founder and CEO of Limitless—to explore how AI-powered memory augmentation is changing what it means to be present, productive, and human.

Dan shares the origin story behind the Limitless Pendant, why he still codes as CEO, and what it’s like to wear a device that records everything you say and hear. They cover everything from stem-winding user stories to controversial pushback from people unready to meet their own data-driven reflection.

This conversation dives deep into:

• What it means to “program yourself” using external memory

• Why forgetting 90% of your life is a bug, not a feature

• The daily feedback loop that made Dan a better father

• The future of AI assistants who take work off your plate before you even ask

• Why Dan believes our kids will be shocked we ever lived without perfect memory

If you’ve ever wanted a more present life, a better mind, or a second brain you can trust—this one is for you.

👉 Learn more at limitless.ai

🎧 Subscribe to The Augmented Life for weekly conversations on optimization, AI, and the future of being human.

What if the most powerful transformation tool isn’t something you add, but something you take away?

In this episode of The Augmented Life, performance coach and Optimal Performance Podcast host Sean McCormick joins Michael Tiffany for a no-holds-barred conversation on radical self-experimentation.

They dive deep into:

• Dry fasting for stem cell release and metabolic reset

• Tracking tools like CGMs, Oura Rings, and neurofeedback

• Why most optimization advice is just noise without personal data

• The link between psychedelics, purpose, and behavior change

• How Sean coaches elite clients toward faster breakthroughs

• And why your relationship with food, sleep, and self might never be the same again

Sean has coached venture capitalists, Navy SEALs, pro athletes, and overwhelmed executives—and he’s walked the walk himself. From 5-day fasts to red light therapy to float tank integration, this is what happens when someone builds a life around asking: What am I truly capable of?

Subscribe now and explore the tools, mindsets, and experiments that redefine the edges of human potential.

Dr. Robert Lufkin is a medical school professor, bestselling author, and former head of diagnostic imaging at UCLA and USC. But what he reveals in this conversation may shake your faith in the healthcare system he helped build.

In this episode of The Augmented Life, Dr. Lufkin joins Michael Tiffany for a radical rethinking of what causes chronic disease and what it actually takes to stay healthy. From Alzheimer’s to cancer, he explains why the root of nearly every major illness is metabolic dysfunction… and why no pill or surgery will ever fix it.

They explore:

• Why symptom management isn’t healthcare

• The overlooked power of lifestyle in reversing disease

• How ketosis is changing Alzheimer’s and mental health treatment

• What happens when doctors finally treat root causes, not just labs

If you’re tired of chasing symptoms—or worried about what your future looks like—this episode offers a very different path.

👉 Subscribe to The Augmented Life and start asking better questions.

What if aging isn’t a slow decline—but an exponential collapse?

And what if the key to beating it isn’t “trying harder”—but building an entirely different strategy?

In this episode of The Augmented Life, Dr. Jeffrey Gladden (Founder & Chief Science Officer of Gladden Longevity) joins Michael Tiffany to challenge everything you think you know about health, performance, and what’s really possible across 100+ years of life.

You’ll learn:

• Why you should never optimize for your chronological age

• The difference between linear and exponential strategies for longevity• How to decode your genetic “icebergs” before they sink your health• Why the body must be 30… while the mind becomes 300• How meditation, love, and creativity are the ultimate longevity levers

Dr. Gladden shares tactical insights, mind-expanding frameworks, and practical ways to start compounding your vitality today.

If you want to be stronger, sharper, and more alive 20 years from now than you are today, this episode is your blueprint.

What if AI wasn’t about intelligence at all—but imagination?

In this episode of The Augmented Life, Michael Tiffany sits down with Helen Todd to explore what it means to center creativity, community, and well-being in a world increasingly defined by algorithms and automation.

Together, they dive into:

• Why Helen believes Sam Altman is wrong about the “Intelligence Age”

• The case for a new era: The Imagination Age

• How to reclaim your attention, intuition, and inner compass in a world designed for distraction

• Why community and embodiment are our best defense against digital disconnection

• The double-edged sword of AI clones, memory augmentation, and “sparring with yourself”

• What it would look like to build AI tools that help us spend less time with tech—and more time being human

Whether you’re a founder, a futurist, or just feeling overwhelmed by the noise, this episode is a hopeful, expansive blueprint for a different kind of future—one rooted in purpose, presence, and play.

Subscribe for more mind-expanding conversations at the intersection of tech, consciousness, and human potential.