Menopause can wreak havoc on mood and body temperature as it signals the end of fertility, but some of the biggest changes it causes are in the brain. Emily Jacobs, assistant professor in the department of psychological and brain sciences at UC Santa Barbara, explains how the precipitous decline in estrogen during the "change of life" disrupts the endocrine system, and why menopause makes some women feel like they're going crazy while others sail through unscathed. Plus: Hear from real women describing the wide range of effects they experienced.