In this episode, made possible through an educational grant from Sandoz Canada, Dr. George Zhanel discusses the latest developments in antimicrobial stewardship, focusing on IV Amox Clav, its clinical applications, safety profile, and the Canadian Leadership on Antimicrobial Real-Life Usage Registry (CLEAR). Gain insights into optimizing antibiotic use and future prospects in antimicrobial development.

Key Topics:

1. IV Amox Clav clinical applications
2. Canadian Leadership on Antimicrobial Usage Registry (CLEAR)
3. Antibiotic stewardship strategies
4. Future developments in antimicrobial agents

Chapters:

00:00 Introduction and Guest Credibility

01:47 Introduction of Dr. George Zhanel and his background

02:41 The journey into IV Amox Clav and its significance

03:21 Overview of the CLEAR registry and its purpose

06:18 Findings from the CLEAR study on IV Amox Clav usage

07:57 Clinical indications and safety profile of IV Amox Clav

10:58 De-escalation and appropriate use of IV Amox Clav

12:34 Use in bacteremia and various infections

13:35 Side effects and safety data of IV Amox Clav

15:02 Dosing strategies and renal adjustments

17:29 Beta-lactamase inhibitors and future antimicrobial development

20:16 Future prospects for new antibiotics in Canada

23:13 Canadian Antimicrobial Resistance Alliance (CARA) and involvement

25:53 Case examples and clinical decision-making in pneumonia and skin infections

31:09 Closing remarks and appreciation for the audience

Resources:

Canadian Leadership on Antimicrobial Real-Life Usage Registry (CLEAR) - https://www.clearregistry.ca

Canadian Antimicrobial Resistance Alliance (CARA) - https://www.cara.ca

Meropenem Vaborbactam - https://www.meropenem.com

Ceftazidime-Avibactam - https://www.ceftazidime-avibactam.com

Guest Links:

LinkedIn - https://www.linkedin.com/in/george-zhanel

Twitter - https://twitter.com/GeorgeZhanel

Young lives have sadly been lost in the 2026 Kent meningitis outbreak. An “unprecedented” cluster centred on the University of Kent, linked to a Canterbury nightclub, and rapidly spreading through student halls and social mixing.

In this timely and hard-hitting podcast episode, Jonny is joined by Intensivists Martin Beed, Peter Brindley (authors of the new primer on infectious meningitis and encephalitis in the Journal of the Intensive Care Society), and Andrew Conway-Morris.

They explore the UK government’s targeted MenB vaccination program for university students and affected schools, the critical importance of early clinical suspicion and prompt antibiotic administration, transmission risks in nightclubs and social settings (including behaviors like vaping), and lessons from past UK and global outbreaks.

The discussion also covers practical public education, healthcare worker resources including useful infographics. The discussion stresses the need for high vigilance, rapid treatment, vaccination where appropriate, and support for public and family mental health during outbreaks.

Packed with actionable clinical guidance and real-world takeaways, this episode is essential listening for healthcare professionals, students, parents, and anyone wanting to understand how to spot, treat, and prevent this devastating disease.

This episode features Sheldon Cheskes discussing advanced defibrillation techniques, including double sequential defibrillation, vector change, and the importance of early intervention in refractory VF.

Gain insights into recent trials, practical protocols, and the impact on neurological outcomes.

Key topics

1. Double sequential defibrillation (DSD)
2. Vector change and pad positioning in defibrillation
3. Timing and dosing of medications in VF
4. Impact of early intervention on neurological outcomes
5. Recent clinical trials: Dose VF and EpiDose

Further Reading:

Defibrillation Strategies for Refractory Ventricular Fibrillation

In this conversation, Peter Brindley and Timothy Caulfield discuss the critical importance of science communication in the face of misinformation and the challenges posed by predatory journals. They explore the societal impact of vaccines, the misuse of scientific terms for marketing purposes (scienceploitation), and the illusions surrounding science, goodness, and opinion. The discussion emphasizes the need for humility in science, the pressures researchers face, and the responsibility of all individuals to advocate for accurate scientific information.

Lessons:

We all have to speak up for science.

Science is a process, not a list of facts.

There is pressure to publish, leading to predatory journals.

Vaccines are one of the most successful biomedical interventions.

Science is often misused as clickbait.

Terms like 'natural' have become meaningless in marketing.

You can't really boost your immune system; it's about maintaining health.

The wellness industry has significant conflicts of interest.

The opinion illusion shows how we are manipulated by online reviews.

Trillions of dollars depend on the credibility of online reviews.

In this conversation, Peter Brindley and Leon Byker sit down with Peter Kruger, President of the College of Intensive Care Medicine, to unpack one of the defining issues facing healthcare today: workforce reform.

Against the backdrop of national workforce reviews across Australia and New Zealand, the discussion explores the tension between aspiration and reality. Governments want equitable access, rural coverage, sustainable systems, and improved wellbeing for clinicians. Colleges want standards, safety, and meaningful careers. Trainees want jobs. Communities want hospitals. Politicians want solutions.

So how do we reconcile all of it?

Dr. Kruger reflects on the growing engagement between specialist colleges and government, particularly around workforce maldistribution, rural and regional care, sub-specialization versus generalism, and the moral complexity of relying on internationally trained doctors. The conversation highlights a key truth: intensive care is a hospital-based, system-dependent specialty. You cannot simply “place a doctor” in a community without the supporting infrastructure.

The episode also tackles uncomfortable but necessary questions:

• Can there be a universal standard for ICU access across vastly different hospital settings?

• Should governments mandate rural placements—or can communities be strengthened from within?

• What role should nurse practitioners and multidisciplinary teams play?

• Are we protecting turf, or protecting patients?

• And how do we better support doctors across the entire career pipeline—from medical student to senior intensivist winding down night shifts?

Throughout, the tone is candid but diplomatic. There’s recognition that workforce reform is complex, long-standing, and resistant to simple solutions. Yet there is also optimism: trust, transparency, and genuine partnership between colleges and government may offer a way forward.

At its core, this episode is about purpose. The shared mission between clinicians, colleges, and governments is delivering safe, effective care to the community. The challenge lies in doing so while balancing standards, sustainability, and humanity.

In this discussion at the College of Intensive Care meeting in Tasmania 2025, Peter Brindley and Leon Byker engage with Prof. John Myburgh, who talks about his long-standing involvement in critical care research and the annual college meeting. John discusses the significance of the grad ceremony and highlights the impact of his research group at the George Institute. He reflects on the contributions of late colleague Ronaldo and praises current leading figures. The conversation delves deep into the ongoing research on steroids in critical care, focusing on genetic endotypes and precision medicine. Other topics covered include interleukin treatments, the evolution of fluid management in treating conditions like diabetic ketoacidosis, and the adaptive platform trials in sepsis. The discussion concludes with reflections on the Queensland Covid-19 vaccine and the broad implications of science, social forces, and politics in critical care advancements.00:00 Welcome and Introductions00:32 John's Involvement with the College01:47 Research and Collaborations03:29 Steroids in Critical Care04:49 Genomic Studies and Future Trials07:18 Challenges in Measuring Outcomes13:27 Interleukins and Sepsis14:18 Fluid Management in Critical Care19:31 COVID-19 and the Queensland Vaccine23:49 Closing Remarks

In this episode of the Critical Care Commute, hosts Peter Brindley and Leon Byker engage in a compelling discussion with Dr. Paul Parks, a prominent emergency physician and advocate for healthcare reform.

Dr. Parks shares his insights on the current state of emergency room care in Alberta, emphasizing the systemic issues that have led to a crisis in emergency services. He describes the overwhelming pressures faced by emergency departments, and highlight the dire need for government acknowledgment and action to address the crisis. He also articulates the challenges of navigating the healthcare system, where patients often wait for hours or even days for care, and advocates for a coordinated response to improve patient outcomes.

Takeaways

1. 'Emerge owns the sins of the system.'
2. 'We are right now in a state of crisis.'
3. 'It's inhumane the conditions that we're seeing.'
4. 'We need a command and control structure.'
5. 'We must move back to being data-driven in our decisions.'
6. 'We have to have the ability to speak truth to power.'
7. 'Patients are waiting for hours, even days, for care.'
8. 'The system is chaotic and disorganized.'
9. 'We need to advocate for transparency and accountability.'

In this conversation, Dr. Marcus Peck shares his harrowing experience of being involved in a medical case that led to a coronial inquest and subsequent investigation by the GMC. He discusses the emotional toll of moral distress, the challenges of navigating legal scrutiny in the medical field, and the importance of community support. The conversation highlights the complexities of patient care, the impact of loss on healthcare professionals, and the lessons learned from difficult experiences in critical care.

Dr Marcus Peck is a consultant in anesthesia and intensive care at Hampshire Hospitals NHS trust, and Network Lead of the Intensive Care Society's Focused Ultrasound for Intensive Care (FUSIC) committee and is joined by Dr Jonny Wilkinson, Consultant in ICU and Anesthesia from North Hampton.

Takeaways:

• Loss is a universal experience in the medical community.
• Moral distress can significantly impact healthcare professionals.
• Legal challenges can arise from complex medical cases.
• Documentation is crucial in protecting healthcare providers.
• Emotional responses to patient outcomes are valid and important.
• Support from colleagues and community is essential during tough times.
• Investigations can feel isolating and shameful for medical professionals.
• Resilience is key in overcoming professional challenges.
• Learning from past experiences can improve future practice.
• Open conversations about these issues can help reduce stigma.

In this short thoughtful episode, we highlight an important Australian tradition: the Acknowledgement of Country. This brief statement, often given at the start of meetings, gatherings, and public events, recognizes the Traditional Custodians of the land, honors their enduring cultural connection to it, and shows respect for Elders past and present. It’s a simple but meaningful way Australians acknowledge history, presence, and identity, and it reflects a national commitment to reconciliation and cultural respect.

In today’s episode, we introduce Dr. Lewis Campbell, a critical care physician from Alice Springs, south of Darwin. Dr. Campbell brings his Northern Territory perspective to our clinical conversation, offering insights shaped by the unique geography, culture, and healthcare challenges of Australia’s Top End.

A concise, engaging listen for your commute.

In this conversation, Iain discusses the launch of MedPod Learn, a platform offering a searchable database of curated medical podcasts. He shares insights on the pricing strategy, including user perceptions about value and affordability, and the decision to offer a free trial to encourage subscriptions.

Takeaways

MedPod Learn offers a searchable database of medical podcasts.

The platform is available on both App Store and Google Play.

User perceptions of pricing can vary significantly.

Some users believe lower prices may lead to undervaluation.

Iain's approach includes a free trial for new users.

The subscription fee is set at £2.99 after the trial.

Market research revealed surprising insights about pricing expectations.

The founder's model aims to attract early adopters.

Engagement strategies are crucial for subscription services.

Understanding user psychology is key to pricing decisions.

https://t.co/Jw9XUrA5nh

Download MedPod Learn from Google Play Store or Apple Store