It’s 1961 and Widukind Lenz, a German pediatrician, is going door to door in his efforts to find out what is causing the epidemic of babies born with shortened limbs and other serious medical conditions. In the U.S., drug company Merrell is battling with Dr. Frances Kelsey at the Food and Drug Administration about the approval for thalidomide. She’s asking for data that shows it’s safe in pregnancy (spoiler alert: it’s not). Meanwhile, Merrell continues to send hundreds of thousands of thalidomide pills to doctors in so-called clinical trials. In November 1961, Dr. Lenz goes public with the results of his medical sleuthing and, as host Katie Hafner puts it, “the proverbial shit hits the proverbial fan.”