We invite statisticians to reflect on the evolving landscape of estimands, encouraging thoughtful consideration of estimation techniques and a deeper exploration of causal inference in clinical trials. The journey through this nuanced statistical terrain unfolds, offering valuable insights for both seasoned professionals and newcomers to the field.

Reference:

Role play reference:

Keene ON, Ruberg S, Schacht A, Akacha M, Lawrance R, Berglind A, Wright D. What matters most? Different stakeholder perspectives on estimands for an invented case study in COPD. Pharmaceutical Statistics. 2020 Jul;19(4):370-87.

Other references:

Naitee Ting (2023) Emerging insights and commentaries – MMRM vs LOCF, Journal of Biopharmaceutical Statistics, 33:2, 253-255, DOI: 10.1080/10543406.2023.2184828

https://www.tandfonline.com/doi/abs/10.1080/10543406.2023.2184828

Wright D, Bratton DJ, Drury T, Keene ON, Rehal S, White IR. Response to Comment on” Emerging insights and commentaries–MMRM vs LOCF by Naitee Ting”. Journal of Biopharmaceutical Statistics. 2023 Sep 23:1-3.

Keene ON. Adherence, per-protocol effects, and the estimands framework. Pharmaceutical Statistics. 2023;1‐4. doi:10.1002/pst.232

Keene ON. Intent-to-treat analysis in the presence of off-treatment or missing data. Pharmaceutical Statistics 2011, 10:191–195, doi: 10.1002/pst.421.

Keene ON, Wright D, Phillips A, Wright M. Why ITT analysis is not always the answer for estimating treatment effects in clinical trials. Contemporary Clinical Trials. 2021 Sep 1;108:106494.

Keene ON, Lynggaard H, Englert S, Lanius V, Wright D. Why estimands are needed to define treatment effects in clinical trials. BMC Medicine. 2023 Jul 27;21(1):276.

In this thought-provoking episode, Benjamin and I provide valuable insights into the dynamic trends shaping the statistical landscape. From AI and data transparency to virtual reality and payer involvement, statisticians are navigating a rapidly evolving terrain. As the industry adapts to these trends, staying informed and embracing new approaches becomes paramount for effective statistical work in drug development. Tune in and stay ahead of the curve!

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So, my fellow statisticians, as you navigate the twists and turns of your statistical career, remember that luck favors the prepared.

Actively create opportunities through networking, training, engaging in exciting projects, and building confidence. Be proactive, invest in your skills, and be ready to seize those lucky moments.

You can also join our exclusive three-day strategy workshop tailored for statisticians, data scientists, and programmers like yourself. Together, let’s break down barriers, foster innovation, and craft a roadmap for your personal and business growth.

Learn more about the workshop here: Strategy Workshop

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Whether you're a seasoned statistician or a curious listener, the insights shared about observational studies, Estimand frameworks, and the future of real-world data research are bound to leave you with a wealth of knowledge.

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As 2023 transitions into 2024, Mirjam encourages listeners to set meaningful goals, providing the motivation to overcome fears and challenge limiting beliefs.

So, here's to breaking free from mental chains and unlocking your true potential!

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Join us as we unravel the dynamics of building a thriving R community and gain valuable learnings from Guillaume's journey.

Tune in for an engaging conversation that goes beyond statistical analysis into the collaborative realm of R enthusiasts at AstraZeneca.

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Resource: R at AZ Blog post

Interested in learning more about R? Check out this course to know more: From SAS to R

In a world where strategy is often misunderstood, this episode serves as a valuable resource for unraveling the true essence of strategy. Empowered by insights from historical examples and a comprehensive approach, you can develop and implement effective strategies in their professional and personal journeys.

For those seeking a deeper dive into the realm of strategy, an upcoming workshop in Frankfurt offers an opportunity to establish personal strategies for success.

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As I look forward to providing more content in the coming year, you can anticipate a wealth of insights and guidance to navigate the strategic landscape.

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The journey toward ethical statistics is collective, involving active implementation, effective communication, collaboration, and a commitment to building trust. It's a shared responsibility with far-reaching impacts on our societies and the world at large.

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