The Gary Null Show

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Higher vitamin K intake linked to lower bone fracture risk late in lifeEdith Cowan University (Australia), November 28,. 2022

Breaking bones can be life changing events—especially as we age, when hip fractures can become particularly damaging and result in disability, compromised independence and a higher mortality risk. But research from Edith Cowan University’s Nutrition and Health Innovation Research Institute has revealed there may be something you can do to help reduce your risk of fractures later in life. In collaboration with the University of Western Australia, the study looked at the relationship between fracture-related hospitalizations and vitamin K1 intake in almost 1,400 older Australian women over a 14.5-year period from the Perth Longitudinal Study of Aging Women. It found women who ate more than 100 micrograms of vitamin K1 consumption—equivalent to about 125g of dark leafy vegetables, or one-to-two serves of vegetables—were 31% less likely to have any fracture compared to participants who consumed less than 60 micrograms per day, which is the current vitamin K adequate intake guideline in Australia for women. There were even more positive results regarding hip fractures, with those who ate the most vitamin K1 cutting their risk of hospitalization almost in half (49%). “Basic studies of vitamin K1 have identified a critical role in the carboxylation of the vitamin K1-dependant bone proteins such as osteocalcin, which is believed to improve bone toughness.”A previous ECU trial indicates dietary vitamin K1 intakes of less than 100 micrograms per day may be too low for this carboxylation. “Vitamin K1 may also promote bone health by inhibiting various bone resorbing agents.”Dr. Sim said eating more than 100 micrograms of vitamin K1 daily was ideal—and, happily, it isn’t too difficult to do.”Consuming this much daily vitamin K1 can easily be achieved by consuming between 75–150g, equivalent to one to two serves, of vegetables such as spinach, kale, broccoli and cabbage,” he said.

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Quercetin found to offer natural protection against influenza virus

Southern Medical Institute (Guangdong China) November 23, 2022

With the flu season upon us, and it looks like they may have a powerful new ally in quercetin, a potent flavonoid and phytonutrient found in many healthy foods and online.

New research reveals:A group of Chinese scientists released a study showing that quercetin can actually block the flu virus from entering cells – which the virus needs to do in order to live and replicate. The team conducted the study by adding quercetin to cells prior to infecting them with influenza, and found that the quercetin-treated cells had significantly lower rates of infection than the cells that had not been treated – an obvious inhibitory effect.Quercetin was found to be effective against Influenza A, as well as its subtypes H1N1 and H3N1. It was also found to work against H5N1, or avian flu – a particularly dangerous subtype with a 60 percent mortality rate. Researchers characterized quercetin as having the potential to be a safe, effective and affordable treatment for Influenza The team noted that quercetin blocked the H protein and, along with it, virus entry. This finding showed that quercetin was effective when added during the process of virus infection, rather than post-virus infection. In other words, quercetin stopped the influenza virus in its tracks, near the beginning of the infection process – which consists of attachment, entry, replication and release. Also encouraging is the fact that viruses are not able to develop resistance to quercetin. In fact, when quercetin was used with anti

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Higher vitamin C levels associated with lower mortality risk during 16-year period

Chinese Academy of Medical Sciences, November 25, 2022

A study reported in the Journal of Epidemiology and Community Health has uncovered an association between higher plasma vitamin C levels and a lower risk of mortality during more than 16 years of follow-up. The study included 473 men and 475 women between the ages of 53 and 84 who were enrolled in the General Population Nutrition Intervention Trial (NIT) cohort in Linxian, China. Plasma samples collected from 1999 to 2000 were analyzed for vitamin C levels. During the 16.4-year follow-up period, among subjects whose plasma vitamin C concentrations were among the top 25%, the adjusted risk of dying from any cause during follow-up was 25% lower than the risk experienced by subjects whose vitamin C levels were among the lowest quarter. Those whose plasma vitamin C levels were among the highest 25% had an adjusted risk of dying from cancer or stroke that was 28% lower and a risk of dying from heart disease that was 35% lower than subjects whose levels were lowest. When subjects with low vitamin C levels (defined as 28 micromoles per liter or below) and normal levels (greater than 28 micromoles per liter) were compared, a normal level was associated with a 23% lower risk of premature mortality and a 38% lower risk of dying from heart disease, in comparison with low levels. As a possible reason for their findings, Shao-Ming Wang and colleagues note that oxidative stress is lowered by vitamin C. Oxidative stress can promote endothelial dysfunction that underlies heart disease by increasing inflammation and lipid peroxidation and decreasing nitric oxide availability. Oxidative stress also causes DNA damage associated with cancer.”This study is the first to find the general benefits for higher plasma vitamin C concentrations on total and cause-specific mortalities, including cancer and heart diseases, in a long-term prospective cohort from China,” the authors announce. “In this long-term prospective Chinese cohort study, higher plasma vitamin C concentration was associated with lower total mortality, heart disease mortality, and cancer mortality. Our results corroborate the importance of adequate vitamin C to human health.”

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Cauliflower Prevent Various Cancers: Thanks to Sulforaphane Compounds

Rugters University, November 19, 2022

Cauliflower contains glucosinolates and thiocyanates — both sulfur-containing phytonutrients that cleanse the body of damaging free radicals. It also contains a substance called sulforaphane (SFN), a compound known to inhibit the occurrence of some cancers in rats caused by carcinogens, primarily colon cancer. In the Rutger’s research, it was found once again that diet does matter in cancer prevention: “Our research has substantiated the connection between diet and cancer prevention, and it is now clear that the expression of cancer-related genes can be influenced by chemopreventive compounds in the things we eat,” said Kong, a professor of pharmaceutics in the Ernest Mario School of Pharmacy at Rutgers, The State University of New Jersey. In this particular study, mice fed a diet high in sulforaphane, the substance naturally occurring in cauliflower and broccoli, enjoyed fewer cancerous tumors, polyps, and smaller tumors in their colons. After three weeks, the mice fed sulforaphane had a 25% decline in tumors and those given double the dose had a 47% decrease in cancerous tumors. The results are obvious, “Our results showed that SFN produced its cancer preventive effects in the mice by inducing apoptosis (programmed cell death) and inhibiting proliferation of the tumors; however, it was not clear what mechanism SFN e

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Healthy plant-based diets associated with lower colorectal cancer risk in menKyung Hee University, South Korea, November 28, 2022

Eating a plant-based diet rich in healthy plant foods—such as whole grains, vegetables, and legumes—and low in unhealthy plant foods—including refined grains, fruit juices, and added sugars—is associated with a lower risk of colorectal cancer in men. The findings are published in the open access journal BMC Medicine.Jihye Kim, the corresponding author, said, “Colorectal cancer is the third-most common cancer worldwide, and the risk of developing colorectal cancer over a lifetime is one in 23 for men and one in 25 for women. Although previous research has suggested that plant-based diets may play a role in preventing colorectal cancer, the impact of plant foods’ nutritional quality on this association has been unclear. Our findings suggest that eating a healthy plant-based diet is associated with a reduced risk of colorectal cancer.” Researchers from Kyung Hee University, South Korea found that among a population of 79,952 American men, those who ate the highest average daily amounts of healthy plant-based foods had a 22% lower risk of colorectal cancer, compared to those who ate the lowest amounts of healthy plant foods. However, the authors did not identify any significant associations between the nutritional quality of plant-based diets and colorectal cancer risk among a population of 93,475 American women. Jihye Kim said, “We speculate that the antioxidants found in foods such as fruits, vegetables, and whole grains could contribute to lowering colorectal cancer risk by suppressing chronic inflammation, which can lead to cancer. As men tend to have a higher risk of colorectal cancer than women, we propose that this could help explain why eating greater amounts of healthy plant-based foods was associated with reduced colorectal cancer risk in men but not women.” The authors found that the association between the nutritional quality of plant-based diets and colorectal cancer risk among men varied by race and ethnicity. Among Japanese American men, colorectal cancer risk was 20% lower for those who ate the highest amount of healthy plant foods per day than for those who ate the lowest amount. Among white men, those who ate the highest amount of highest amount of healthy plant foods had a 24% lower colorectal cancer risk than those who ate the lowest amount. The authors did not identify any significant associations between plant-based diets and colorectal cancer risk among African American, Latino or Native Hawaiian men.

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Green Mediterranean diet reduces twice as much visceral fat as traditional Mediterranean dietBen-Gurion University of the Negev (Israel), November 28, 2022

Following the green Mediterranean diet significantly reduces visceral adipose tissue, a type of fat around internal organs that is much more dangerous than the extra “tire” around your waist. Recently, researchers compared the green Mediterranean diet to the traditional Mediterranean diet and a non-Mediterranean healthy diet in a large-scale clinical interventional trial—the DIRECT PLUS. Subsequent analysis found that the green Mediterranean diet reduced visceral fat by 14%, the Mediterranean diet by 7% and the non-Mediterranean healthy diet by 4.5%. The study was published in BMC Medicine. Reducing visceral fat is considered the true goal of weight loss, as it is a more important indicator than a person’s weight or the circumference of their waist. Visceral fat aggregates over time between organs, and produces hormones an

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Pomegranate juice found to combat systemic inflammation throughout the bodyUniversity of Bologna (Italy) & University of Auckland (New Zealand), November 18, 2022

The researchers from the University of Bologna and the University of Auckland looked at the effects of the juice of the pomegranate in particular, which has already been shown to help conditions like diabetes, atherosclerosis and prostate cancer. Chronic inflammation, a response by the body to infection and tissue damage, has been linked to the development of disorders such as inflammatory bowel disease, asthma, rheumatoid arthritis, chronic obstructive pulmonary disease and psoriasis. After analyzing an extensive number of existing studies on pomegranate, they found plenty of evidence that shows pomegranate juice can indeed help inflammation-related diseases, although they pointed out that a definitive relationship has not been officially established. Most of the scientific research on pomegranate’s health benefits has been carried out on cell culture or animal models, they point out, and clinical trials with humans are generally lacking. They found that pomegranate seems to show the most promise in fighting cardiovascular diseases, metabolic syndrome and diabetes, but the researchers urge care, calling on further studies to determine its specific effects and explain why the fruit juice seems to help chronic inflammatory diseases. A Case Western study published in the Journal of Inflammation, for example, found that the extract of pomegranate significantly inhibited the buildup of damaging proteins associated with Alzheimer’s disease by as much as a half. This effect is being attributed to its ability to protect against the oxidative stress that leads to beta-amyloid deposits. Researchers have also demonstrated its potential to help those with prostate, colon and breast cancer. In studies where tumor cells were treated with pomegranate, cell migration dropped and the cancer was stopped from spreading to other areas of the body. Pomegranate juice came out on top in a study of beverages known for their antioxidant content carried out by the Center for Human Nutrition at the University of California – Los Angeles’s David Geffen School of Medicine. While all of the beverages examined – blueberry juice, acai berry juice, green tea, white tea, Concord grape juice, orange juice, pomegranate juice and red wine, had impressive amounts of antioxidants, pomegranate juice outperformed them all when it came to polyphenols and protective benefits. Its antioxidant potency composite index was a full 20 percent higher than any of the other drinks that were put through the rigorous testing.

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Handful of walnuts daily cuts risk of asthmaUniversity of North’s Carolina, November 20, 2022

Here’s another reason for you to eat more walnuts as a type of vitamin E, found in these nuts, may prevent the risk of asthma attacks by reducing airway inflammation. According to researchers, sufferers of a common breathing condition, taking it as part of the study, were also found to have less sticky mucus in their lungs. Gamma-tocopherol is a major form of vitamin E, which is abundant in nuts like walnuts and pecans and in the legume peanut, as well as seed oils such as corn, soybean and sesame. Senior study author Professor Michelle Hernandez from the University of North’s Carolina school of medicine said epidemiologic data suggested that people with high amounts of vitamin E in their diet were less prone to asthma and allergic disease. The team randomly analysed participants into two groups, one that received gamm

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The ultimate stress buster: L-theanine

Columbia University Medical Center,  November 16, 2022

Honestly, who would have thought that stress can cause heart damage equivalent to smoking five cigarettes?

This is according to a study conducted by Columbia University Medical Center and published in the American Journal of Cardiology. 

The study reveals how an amino acid known as L-theanine reduces both stress levels and heart rate.  As a way to increase stress levels, scientists asked 12 participants to solve a mentally stressful task in four double blind trials.

L-theanine was given to participants in one of the four trials before dealing with the stressful task.  In the second group, study subjects took L-theanine midway through the work.  In the third and fourth variations, subjects were respectively given a placebo and nothing at all before attempting the task.

In comparison to the placebo group, there was a reduced amount of immunoglobulin (a stress marker in saliva released by the immune system after exposure to viruses, bacteria, and other foreign entities) and a lower heart rate in participants who took L-theanine.

The researchers explained that L-theanine works by suppressing the sympathetic nervous system responsible for the ‘fight or flight’ response during emergency situations.

This is achieved by blocking a chemical known as glutamate (L-glutamic acid) that carries electric signals transmitted from nerve cells to the rest of the body cells. The conclusion was that L-theanine plays a major role in terms of influencing psychology (mind) and physiology (body) function during stressful situation.

Greater flavonoid intake associated with less arterial calcification

Edith Cowen University (Australia), November 23 2022. 

The December 2022 issue of Arteriosclerosis, Thrombosis, and Vascular Biology reported a study that uncovered a relationship between greater consumption of plant compounds known as flavonoids and decreased calcification in the abdominal aorta, which supplies blood to the abdominal organs and lower limbs. 

Greater abdominal aortic calcification has been associated with an increased risk of stroke, heart attack and dementia. 

The study included 881 participants in the Perth Longitudinal Study of Ageing Women. Dietary questionnaire responses were analyzed to determine total and individual flavonoid intake. 

Women whose total flavonoid intake was among the top 25% of participants had a 36% lower risk of extensive abdominal aortic calcification than women whose intake was among the lowest 25%. Among women whose intake of individual flavonoids known as flavan-3-ols and flavonols was among the top 25%, respective risks were 39% and 38% lower. 

Those who consumed 2–6 cups per day of black tea (the main source of total flavonoid intake in this study), had a 16%–42% lower risk of extensive abdominal aortic calcification than women who were not tea drinkers. 

“In most populations, a small group of foods and beverages—uniquely high in flavonoids—contribute the bulk of total dietary flavonoid intake,” first author Ben Parmenter noted. “The main contributors are usually black or green tea, blueberries, strawberries, oranges, red wine, apples, raisins/grapes and dark chocolate.” 

“Out of the women who don’t drink black tea, higher total non-tea flavonoid intake also appears to protect against extensive calcification of the arteries,” he continued. “This implies flavonoids from sources other than black tea may be protective against abdominal aortic calcification when tea is not consumed.”

“Abdominal aortic calcification is a major predictor of vascular disease events, and this study shows intake o

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Liz Question 

Greater niacin intake linked with lower mortality risk among cancer patients during 15-year period

First People’s Hospital in China, November 21 2022. 

A study reported  in BMC Cancer found that men and women with cancer who consumed a higher amount of niacin (vitamin B3) from food or supplements had a lower risk of dying from the disease during a 15-year follow-up period than patients with lower consumption. 

Researchers analyzed data from 3,504 cancer patients who participated in the National Health and Nutrition Examination Surveys (NHANES) between 1999 and 2014. 

Among participants whose niacin intake from food was among the top 25%, the adjusted risk of mortality from all causes was 27% lower, and the risk of dying from cancer was 49% lower during follow-up compared with participants whose intake was among the lowest 25%. Each 10 mg per day increase in dietary niacin was associated with an adjusted 11% lower risk of all-cause mortality and a 19% reduction in the risk of cancer mortality. 

Total daily niacin intake was 76.4 mg per day among participants who reported using niacin supplements compared to 21.4 mg per day among those who did not supplement. Cancer mortality was 52% lower among those who supplemented with niacin versus unsupplemented participants. 

“Our study found that higher intake of dietary niacin was associated with lower risk of mortality from all-causes and cancer mortality,” Hongyan Ying Taizhou of First People’s Hospital in China and colleagues concluded. “The consumption of niacin had a dose-effect relationship for all-cause mortality, but not for cancer mortality. This conclusion was verified by the data of supplemental niacin consumption.”

Study: Antioxidant flavonols linked to slower memory decline

Rush University Medical Center, November 22, 2022

People who eat or drink more foods with antioxidant flavonols, which are found in several fruits and vegetables as well as tea and wine, may have a slower rate of memory decline, according to a study published in Neurology.

“It’s exciting that our study shows making specific diet choices may lead to a slower rate of cognitive decline,” said study author Thomas M. Holland, MD, MS of Rush University Medical Center in Chicago. “Something as simple as eating more fruits and vegetables and drinking more tea is an easy way for people to take an active role in maintaining their brain health.”

The study involved 961 people with an average age of 81 without dementia. They filled out a questionnaire each year on how often they ate certain foods. They also completed annual cognitive and memory tests including recalling lists of words, remembering numbers and putting them in the correct order. They were also asked about other factors, such as their level of education, how much time they spent doing physical activities and how much time they spent doing mentally engaging activities such as reading and playing games. They were followed for an average of seven years.

The people were divided into five equal groups based on the amount of flavonols they had in their diet. While the average amount of flavonol intake in US adults is about 16 to 20 milligrams (mg) per day, the study population had an average dietary intake of total flavonols of approximately 10 mg per day. The lowest group had an intake of about 5 mg per day and the highest group consumed an average of 15 mg per day; which is equivalent to about one cup of dark leafy greens.

After adjusting for other factors researchers found that the cognitive score of people who had the highest intake of flavonols declined at a rate of 0.4 units per decade more slowly than people whose had the lowest intake. Holland noted this is probably due to the inherent antioxidant and anti-inflammatory properties of flavonols.

T

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Almonds can help you cut calories

University of South Australia, November 20, 2022

Weight loss is never an easy nut to crack, but a handful of almonds could keep extra kilos at bay according to new research from the University of South Australia.

Examining how almonds can affect appetite, researchers found that a snack of 30-50 grams of almonds could help people cut back on the number of kilojoules they consume each day.

Published in the European Journal of Nutrition, the study found that people who consumed almonds – as opposed to an energy-equivalent carbohydrate snack – lowered their energy intake by 300 kilojoules (most of which came from junk food) at the subsequent meal.

“Our research examined the hormones that regulate appetite, and how nuts – specifically almonds – might contribute to appetite control. We found that people who ate almonds experienced changes in their appetite-regulating hormones, and that these may have contributed to reduced food intake (by 300kJ).”

The study found that people who ate almonds had 47 per cent lower C-peptide responses (which can improve insulin sensitivity and reduce the risk of developing diabetes and cardiovascular disease); and higher levels of glucose-dependent insulinotropic polypeptide (18 per cent higher), glucagon (39 per cent higher), and pancreatic polypeptide responses (44 per cent higher). Glucagon sends satiety signals to the brain, while pancreatic polypeptide slows digestion which may reduce food intake, both encouraging weight loss.

“Almonds are high in protein, fibre, and unsaturated fatty acids, which may contribute to their satiating properties and help explain why fewer kilojoules were consumed.”

The findings of this study show that eating almonds produce small changes to people’s energy intake, Dr Carter says this may have clinical effects in the long term.

Probiotics help maintain a healthy microbiome when taken with antibiotics

Texas Christian University, November 18 2022. 

A systematic review published in the Journal of Medical Microbiology helps answer the question concerning whether probiotics should be taken along with antibiotics to support gut health. 

Although probiotics decrease the adverse gastrointestinal effects caused by antibiotics, their ability to preserve intestinal microbial composition that is negatively impacted by antibiotic therapy is not well understood. 

“Like in a human community, we need people that have different professions because we don’t all know how to do every single job,” she explained. “And so, the same happens with bacteria. We need lots of different gut bacteria that know how to do different things.”

While it is well known that antibiotics destroy some beneficial intestinal microorganisms, some healthcare professionals have expressed a concern that administering probiotics to antibiotic-treated patients could further alter the established gut microbe balance.

The review included 29 studies published during a 7-year period. The authors concluded that consuming probiotics with antibiotics can prevent or reduce some changes caused by antibiotics to the microbiome. “When participants take antibiotics, we see several consistent changes in some bacterial species,” Dr Marroquin observed. “But when treatment was combined with probiotics, the majority of those changes were less pronounced and some changes were completely prevented.”

New study shows repeated stress accelerates aging of the eye

University of California, Irvine, November 21, 2022

New research from the University of California, Irvine, suggests aging is an important component of retinal ganglion cell death in glaucoma, and that novel pathways can be targeted when designing new treatments for glaucoma pa

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Potatoes can be part of a healthy dietLouisiana State University, November 18, 2022

When we think of healthy vegetables, we don’t think of potatoes, but we should. Potatoes have developed a reputation for causing weight gain and an increased risk for type 2 diabetes, and often find themselves on a list of foods to avoid, especially for individuals with insulin resistance. However, a new study from Pennington Biomedical Research Center at Louisiana State University, published in the Journal of Medicinal Food, says that potatoes actually did not increase that risk, are filled with key nutrients, and packed with health benefits. Candida Rebello, PhD, an assistant professor at Pennington Biomedical, said, “We demonstrated that contrary to common belief, potatoes do not negatively impact blood glucose levels. In fact, the individuals who participated in our study lost weight.” “People tend to eat the same weight of food regardless of calorie content in order to feel full,” Rebello explained. “By eating foods with a heavier weight that are low in calories, you can easily reduce the number of calories you consume. The key aspect of our study is that we did not reduce the portion size of meals but lowered their caloric content by including potatoes. Each participant’s meal was tailored to their personalized caloric needs, yet by replacing some meat content with potato, participants found themselves fuller, quicker, and often did not even finish their meal. In effect, you can lose weight with little effort.” The study involved 36 participants between the ages of 18 and 60 who were overweight, had obesity, or insulin resistance. Insulin resistance refers to a health condition in which the body’s cells do not respond well to insulin and glucose does not enter into the cells to make energy. Insulin resistance is linked to obesity, high blood pressure, high cholesterol, and type 2 diabetes Participants were fed precisely-controlled diets of widely available common foods including either beans, peas, and meat or fish, or white potatoes with meat or fish. Both diets were high in fruit and vegetable content and substituted an estimated 40% of typical meat consumption with either beans and peas or potatoes. Previous studies have shown that eating beans and peas improves blood glucose levels in individuals with newly diagnosed type 2 diabetes. To increase the dietary fiber component of the potatoes, they were boiled with the skin intact and then refrigerated between 12 and 24 hours. Potatoes were incorporated into the main lunch and dinner entrées, and served together with sides such as mashed potatoes, oven-roasted potato wedges, potato salad, and scalloped potatoes with lunch and dinner entrees. “We prepared the potatoes in a way that would maximize their fiber content. When we compared a diet with potatoes to a diet with beans and peas, we found them to be equal in terms of health benefits,” Rebello said. “People typically do not stick with a diet they don’t like or isn’t varied enough. The meal plans provided a variety of dishes, and we showed that a healthy eating plan can have varied options for individuals striving to eat healthy. In addition, potatoes are a fairly inexpensive vegetable to incorporate into a diet.”

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Celery Seed Extract Lowers High Blood Pressure in Human Study

University of Chicago Medical Center, November 8, 2022

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Lycopene, lutein supplements show skin protection from within against UV radiationLeibniz Research Institute for Environmental Medicine (Germany), November 10, 2022

The study’s findings, published in the British Journal of Dermatology , indicated that oral supplementation with the carotenoids changed the expression of genes that are indicators of oxidative stress, photo-dermatoses and photo-aging. “To the best of our knowledge we show here for the 1st time that (i) tomato nutrient complex as well as lutein do not only protect healthy human skin against UVB/A, but also against long wave UVA1 radiation, and (ii) that oral photo-protection of healthy human skin can be demonstrated at the level of HO-1, ICAM-1 and MMP-1 gene expression,” wrote researchers from IUF – Leibniz Research Institute for Environmental Medicine in Dusseldorf. Heme oxygenase-1 (HO-1), intercellular adhesion molecule-1 (ICAM-1) and matrix metalloproteinase-1 (MMP-1) are reported to be UVA1/UVB radiation-inducible genes.“On top of that, as part of the photo-aging process we have evidence of the effect of our ingredients on the levels of expression of genes involved in collagen degradation, suggesting a link not only to skin health but also to skin appearance. This study suggests an effect of natural antioxidants on overall skin wellness, which is relevant for men and women in all age groups.” The new study included 65 healthy volunteers aged between 18 and 60. The participants were randomly assigned to randomly consume 20 mg per day of the tomato nutrient complex or placebo for 12 weeks, or 20 mg per day of lutein or placebo for 12 weeks. A two-week washout period separated the placebo and active intervention periods. At the beginning and at the end of each phase the skin was irradiated.Results of the placebo-controlled, double blinded, randomized cross-over study indicated that the tomato nutrient complex (TNC) totally inhibited the upregulation of HO-1, ICAM-1 and MMP1 mRNA by both UVA1 and UVA/B. On the other hand, lutein only completely inhibited gene expression if taken during the first 12 weeks (ie. prior to placebo), while a significantly smaller effect was observed if it was taken during the second 12 week phase (ie. after placebo), compared to TNC.

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Diallyl trisulfide in garlic induces apoptosis in primary effusion lymphomaKyoto Pharmaceutical University (Japan), November 7, 2022

Reports from Kyoto Pharmaceutical University stated, “The allyl sulfides, including diallyl sulfide (DAS), diallyl disulfide (DAD), and diallyl trisulfide (DAT), contained in garlic and members of the Allium family, have a variety of pharmacological activities. Therefore, allyl sulfides have been evaluated as potential novel chemotherapeutic agents.” Our news editors obtained a quote from the research, “Here, we found that DAT inhibited nuclear factor-kB (NF-kB) signaling and induced apoptosis in primary effusion lymphoma (PEL), a subtype of non-Hodgkin’s B-cell lymphoma caused by Kaposi’s sarcoma-associated herpesvirus (KSHV). We examined the cytotoxic effects of DAS, DAD and DAT on PEL cells. DAT significantly reduced the viability of PEL cells compared with uninfected B-lymphoma cells, and induced the apoptosis of PEL cells by activating caspase-9. DAT induced stabilization of IkBa, and suppressed NF-kB transcriptional activity in PEL cells. We examined the mechanism underlying DAT-mediated IkBa stabilization. The results indicated that DAT stabilized IkBa by inhibiting the phosphorylation of IkBa by the IkB kinase (IKK) complex. Furthermore, DAT induced proteasomal degradation of TRAF6, and DAT suppressed IKKb-phosphorylation through downregulation of TRAF6. It is known that activation of NF-kB is essential for survival of PEL cells. In fact, the NF-kB inhibit

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The TRUTH about IVERMECTIN (13:00)

 

Korean ginseng prevents oxidative stress caused by workOhiol State University, November 07, 2022

People who are stressed may find relief from taking Korean ginseng. A study published in the Journal of Medicinal Food has revealed that the Korean ginseng called GINST15 can help reduce stress, mentally and physically. In the study, researchers from The Ohio State University in the U.S. found that Korean ginseng prevents damage caused by intense work stress due to its antioxidants. For the study, the researchers aimed to determine the effects of GINST15 supplement on hormonal and inflammatory responses to physical stress in humans. They recruited 10 women and nine men to participate in the study. The participants were tasked to complete three two-week treatment cycles with 960 milligrams (mg) of the Korean ginseng supplement, 160 mg of the Korean ginseng supplement, or a placebo, separated by a one-week washout period. After the treatment, the participants underwent an intense resistance exercise to induce physical stress. The participants also provided blood samples at rest and at various points after the exercise, particularly immediately, 30 minutes, 60 minutes, and 24 hours after exercise. Then, the researchers measured the levels of cortisol, superoxide dismutase, total glutathione, nonspecific antioxidant activity, total antioxidant power, and creatine kinase. The results showed that the supplementation of Korean ginseng reduced cortisol and increased enzymatic and nonspecific antioxidant activity. In addition, the high dose of the Korean ginseng supplement (960 mg) greatly reduced muscle damage and hypothalamic pituitary adrenal (HPA) responses to physical stress 24 hours after the intense exercise. Based on the findings of the study, the researchers concluded that taking Korean ginseng supplements can help ward off mental and physical stress by reducing cortisol levels and muscle damage.

When low-income families can meet their basic needs, children are healthierBoston Medical Center, November 8, 2022

A series of reports from five cities across the US found that young children and their parents are healthier when they are able to afford basic needs. New research published by Children’s HealthWatch, headquartered at Boston Medical Center, highlights the need for policymakers to improve access to and effectiveness of programs that enable all families with low incomes to afford basic needs such as food, shelter, utilities, medical care, prescription medicines and childcare.Researchers surveyed more than 18,000 families of children under age 4 in the emergency departments and primary care clinics at urban hospitals in Baltimore, Boston, Minneapolis, Philadelphia, and Little Rock. The study team created a composite measure of hardships that included a family’s ability to afford food, utilities, and health care, and maintain stable housing. All hardships described in the study have previously been associated with poor child and caregiver health. This study, however, examined the differences between children living in hardship-free families versus those in families with any or multiple hardships. In all cities, living in a hardship-free family was associated with good overall health for children and caregivers, positive developmental outcomes for young children, and positive mental healthamong mothers. Nearly half of families interviewed at Hennepin County Medical Center in Minneapolis reported that they were hardship-free. At Boston Medical Center, only about one quarter of the families surveyed reported zero hardships, which may be due to higher housing costs. The reports also examine the link between childcare constraints, when parents are unable to work or attend school because of an inab