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Higher vitamin C levels associated with lower mortality risk during 16-year periodChinese Academy of Medical Sciences, August 20 2022

A study reported in the Journal of Epidemiology and Community Health has uncovered an association between higher plasma vitamin C levels and a lower risk of mortality during more than 16 years of follow-up.

The study included 473 men and 475 women between the ages of 53 and 84.

Among subjects whose plasma vitamin C concentrations were among the top 25%, the adjusted risk of dying from any cause during follow-up was 25% lower than the risk experienced by subjects whose vitamin C levels were among the lowest quarter. Those whose plasma vitamin C levels were among the highest 25% had an adjusted risk of dying from cancer or stroke that was 28% lower and a risk of dying from heart disease that was 35% lower than subjects whose levels were lowest.

When subjects with low vitamin C levels (defined as 28 micromoles per liter or below) and normal levels (greater than 28 micromoles per liter) were compared, a normal level was associated with a 23% lower risk of premature mortality and a 38% lower risk of dying from heart disease, in comparison with low levels.

As a possible reason for their findings, Shao-Ming Wang and colleagues note that oxidative stress is lowered by vitamin C. Oxidative stress can promote endothelial dysfunction that underlies heart disease by increasing inflammation and lipid peroxidation and decreasing nitric oxide availability. Oxidative stress also causes DNA damage associated with cancer.

Pomegranate-cocoa blend helps improve aging men’s symptomsShetty Hospital (India), August 19 2022.

A study published in the International Journal of Medical Science found benefits for supplementing with a combination of extracts of Punica granatum (pomegranate) fruit rind and Theobroma cocoa seed extracts in middle-aged men.

Previous research that investigated the effects of a blend of extracts of pomegranate fruit rind and cocoa seed in young men resulted in increases in serum and free testosterone levels as well as muscle strength and size. The current study included 120 men between the ages of 36 to 55 years who received 200 mg or 400 mg of pomegranate-cocoa extract or a placebo for 8 weeks. All participants were assigned to a program consisting of 30 minutes of walking per day for 5 days per week.

At the end of the 7-week period, both doses of pomegranate-cocoa extracts were associated with significant improvement in aging males’ symptom scores, free and total testosterone levels, strength and perceived stress compared to the beginning of the study and to the placebo group.

The authors concluded that pomegranate-cocoa “is a well-tolerated, safe, and effective nutraceutical blend that boosts sexual function, testosterone level, and psychological and general well-being in aging males.”

Placebo effect demonstrates healing power of the mind

Harvard Medical School, August 13, 2022

Experts at Harvard Medical School advocate that the placebo effect be received with more positivity, rather than viewed as a deceptive or inaccurate measure designed to test health. They conclude that the power of thought can be extremely effective in helping people heal, focusing on physiological changes that have been linked to the placebo effect.

The placebo effect involves someone being given medicine that is actually typically nothing more than a sugar pill which does not contain active ingredients. Many times, patients receiving a placebo who are in need of healing a certain condition report feeling significantly better, if not altogether healed.

The experts at Harvard explai

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GlyNAC supplementation reverses aging hallmarks in aging humansBaylor College of Medicine, August 19, 2022

A randomized, double blind human clinical trial conducted by researchers at Baylor College of Medicine reveals that supplementation with GlyNAC—a combination of glycine and N-acetylcysteine—improves many age-associated defects in older humans and powerfully promotes healthy aging. This is relevant because until now, there have been no solutions toward improving many of these age-related declines in people.

Published in The Journals of Gerontology: Series A, the study shows that older humans taking GlyNAC for 16-weeks improved many characteristic defects of aging. This includes oxidative stress, glutathione deficiency and multiple aging hallmarks affecting mitochondrial dysfunction, mitophagy, inflammation, insulin resistance, endothelial dysfunction, genomic damage, stem cell fatigue and cellular senescence. These were associated with improvements in muscle strength, gait speed, exercise capacity, waist circumference and blood pressure.

The improvements in oxidative stress, glutathione levels and mitochondrial function in the muscle tissue of older humans taking GlyNAC were similar to the improvements in organs such as the heart, liver and kidneys of aged mice supplemented with GlyNAC as reported in the researchers’ recent publication. Taken together, the results of these studies show that GlyNAC supplementation can improve these defects in many different organs of the body. “GlyNAC supplementation in aging mice increased their length of life mice by 24%,” said Sekhar. “Gait speed is reported to be associated with survival in older humans. Our randomized clinical trial found a significant improvement in gait speed in older humans supplemented with GlyNAC. This raises the interesting question of whether GlyNAC supplementation could have implications for survival in people.”

Mitochondria generate energy needed for supporting cellular functions. However, the ability of mitochondria to work well declines as we age. How to improve the ability of these failing mitochondria to work is not well understood, and therefore no solutions have been available. Sekhar’s group discovered earlier that supplementing GlyNAC in aged mice corrected malfunctioning mitochondria. However, to definitively determine whether GlyNAC supplementation benefited people, a placebo-controlled randomized clinical trial was required.

After 16-weeks of GlyNAC supplementation, mitochondrial function of older people improve toward levels found in young people. This was accompanied by improvements in multiple additional outcomes as reported in the publication. Analysis of the molecular data from the trial suggests that the GlyNAC supplementation is able to fill cells with younger and more efficient mitochondria. “Collectively these exciting new discoveries hold great promise for improving our mitochondrial and general health as we age,” Sekhar said.

A second vital benefit offered by supplementing GlyNAC is that it also helps protect the body from an important problem called oxidative stress. GlyNAC supplementation corrects glutathione deficiency and lowers oxidative stress in older humans back to youthful levels, thereby solving both problems.

“One of the intriguing questions from this trial is why so many improvements occur toward promoting health. We believe that this is due to the combined effort of three separate components—glycine, cysteine (from NAC) and glutathione, and not just due to glutathione itself. Glycine and cysteine are both very important for cellular health on their own, and GlyNAC provides both. Glycine and cysteine are building blocks to form glutathione, which also has health benefits. We believe that the improvements in this trial and in our previous studies are the result of the combined e

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Consuming green vegetables, supplements suppresses inflammatory bowel disease

Sichuan University in China and from Cedars Sinai Medical Center, August 17, 2022

The dietary supplement chlorophyllin alleviates inflammatory bowel disease (IBD), including Crohn’s disease and ulcerative colitis, according to researchers from the Center for Diabetes and Metabolism Research at Sichuan University in China and from Cedars Sinai Medical Center in Los Angeles. In addition, chlorophyllin significantly reduces mortality related to IBD, weight loss, diarrhea and hidden blood in the stool, intestinal epithelial damage and infiltration of inflammatory cells. The findings are published ahead of print in the American Journal of Physiology-Gastrointestinal and Liver Physiology, and the study has been chosen as an APS select article for August. Current therapeutics for IBD include medications that suppress the immune system (immunosuppressants) and surgery. However, long-term use of immunosuppressive treatments could result in severe adverse effects, including opportunistic infections and even organ failure. In this study, researchers found taking an oral chlorophyllin supplement—a compound derived from the green pigment found in plants—reduced colitis and abnormalities in the intestinal epithelia of mice. Also, consumption of green vegetables and chlorophyllin may be helpful for IBD recovery, in part through alleviation of inflammation and autolysosomal flux (a process that uses lysosome to degrade and remove toxic molecules and organelles). Green pigment found in these foods and supplements can initiate a feeding signaling to modulate autophagy in the cells, which suppresses IBD symptoms.

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Coriander is a potent weapon against antibiotic resistant bacteria

University of Beira Interior (Portugal) August 10, 2022

The problem of antibiotic resistant bacteria has been deemed a public health crisis, with the Centers for Disease Control and Prevention (CDC) reporting that invasive MRSA – or methicillin-resistant S. aureus – infections affect 80,000 people globally a year, and claim over 11,000 lives. But, what the CDC will never tell you is how coriander can potentially save lives. Researchers in Portugal now say that that the oil from coriander – a common kitchen spice – is quite toxic to a wide range of harmful bacteria, leading to hopes that it may be enlisted in the fight against MRSA and other pathogens. The scientific research about coriander is promisingResearchers at University of Beira Interior used flow cytometry to study the effects of coriander oil on 12 different disease-causing types of bacteria, including E. coli, Salmonella, B. cereus and MRSA. In the study, published in Journal of Medical Microbiology, the oil significantly inhibited bacterial growth – especially that of MRSA and E. coli.

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Tumour blood supply stopped in its tracks by modified natural compound

University of New South Wales (Australia), August 10, 2022

Researchers have discovered how the modified natural compound dextran-catechin disrupts formation of blood vessels that fuel growth in the childhood cancer neuroblastoma. Researchers have discovered how a modified natural compound disrupts angiogenesis, the formation of blood vessel networks, in neuroblastoma tumours, stopping them laying down the vital supply lines that fuel cancer growth and spread. Dextran catechin is a sugar based conjugated form of catechin commonly found in green tea, red wine, dark chocolate and apple peels. Lead author Dr Orazio Vittorio of Children’s Cancer Institute found that the natural polyphenol catechin slows tumour growth in the laboratory but breaks down too quickly in the body to be effective.

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Study: Regular consumption of citrus fruits can reduce dementia risk by 15%

Tohoku University (Japan), August 4, 2022

Dementia continues to affect more people worldwide, and countries with aging populations like Japan are especially vulnerable. To address this matter, researchers from Tohoku University studied the health benefits of eating citrus fruits. According to the study findings, regular consumption of citrus fruits like oranges, grapefruits, lemons or limes could help reduce the risk of dementia among older adults by almost 15 percent. The research team hopes that the dietary approach could be both a simple and effective solution for dementia prevention. Findings from some cell and animal experiments have shown that citrus flavonoids can cross the blood-brain barrier and play a part in antioxidant and anti-inflammatory actions. Earlier studies suggest that this could help reverse and repair some forms of cellular damage.

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Olive oil consumption found to reduce risk of death due to cancer, heart disease and Alzheimer’s

Harvard School of Public Health, August 14, 2022

According to a study, replacing butter or full-dairy fat with half a tablespoon or more of olive oil can help increase your chances of living longer. The study was conducted by experts from the Harvard T.H. Chan School of Public Health and published in the American Journal of Cardiology. The study revealed that people who used seven grams or more (at least half a tablespoon) of olive oil as a dressing or with bread had a reduced risk of dying from Alzheimer’s disease, cancer, heart disease or respiratory disease compared to those who rarely or never consumed olive oil. Findings also showed that replacing 10 grams a day (about 3/4 tablespoons ) of butter, margarine, mayo or dairy fat with the same amount of olive oil was linked to an impressive eight to 34 percent lower risk of disease-related death. For the study, the researchers analyzed data from 60,582 healthy adult women and 31,801 healthy adult men from the Nurses’ Health Study and the Health Professionals Follow-up Study. During the 28-year follow-up, the volunteers had a diet assessment every four years that asked them how often they consumed certain foods, fats and oils on average. The assessment also checked which brand or type of oils they used for cooking or at the table.

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Cutting 1 gram from daily salt intake could ward off nearly 9 million cases of stroke/heart disease

British Medical Journal, August 16, 2022

A modest cut of just 1 gram in daily salt intake could ward off nearly 9 million cases of heart disease and strokes and save 4 million lives by 2030, suggest the estimates of a modeling study published in the open access journal BMJ Nutrition Prevention & Health. Salt intake in China is one of the highest in the world, averaging 11 g/day—over twice the amount recommended by the Chinese government. High salt intake drives up blood pressure and therefore the risk of cardiovascular disease, which accounts for 40% of all deaths in China every year. The researchers set out to estimate the health gains that could be achieved by reducing salt intake across the nation, with the aim of helping to inform the development of a doable salt reduction program.

Given that, on average, adults in China consume 11 g/day of salt, reducing this by 1 g/day should lower average systolic blood pressure by about 1.2 mmHg. And if this reduction were achieved in a year and sustained, some 9 million cases of heart disease and stroke could be prevented by 2030—4 million of them fatal.

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Getting Adequate Amount Of Vitamin D Prevents Harmful Inflammation

University of South Australia, August 7, 202

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New study shows Rhodiola rosea root might be beneficial for managing type 2 diabetes

University of California at Irvine, August 15, 2022

A team of researchers led by the University of California, Irvine has discovered that treatment with an extract from the roots of the Rhodiola rosea plant might be effective for helping manage type 2 diabetes, showing promise as a safe and effective non-pharmaceutical alternative. The study, recently published online in Scientific Reports, found that in a mouse model of human type 2 diabetes, Rhodiola rosea lowered fasting blood sugar levels, improved response to insulin injections, modulated the composition of bacteria in the gastrointestinal tract and decreased several biomarkers of inflammation. The team utilized a genetically engineered mouse model that develops obesity, insulin resistance and high blood sugar, similar to advanced human type 2 diabetes, to test whether Rhodiola rosea could improve glucose homeostasis. In the study, cohorts of age-matched male and female mice were randomly assigned to one of two groups: control, which received water, or experimental, which received Rhodiola rosea extract.

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Meta-analysis concludes benefits for selenium supplementation in cognitively impaired individuals

Instituto de Pesquisa Pelé Pequeno Príncipe (Brazil), August 15 2022. 

A systematic review and meta-analysis published  in Nutrients found that supplementing with selenium was associated with improved levels of the mineral and the antioxidant enzyme glutathione peroxidase, as well as better cognitive function among patients with mild cognitive impairment (MCI) or Alzheimer disease (AD). “For the first time, our study demonstrated, through a systematic review and meta-analysis, the possible benefits of selenium supplementation on selenium levels in patients with MCI or AD, as well as on markers of oxidative stress and on cognitive test performance,” Meire Ellen Pereira and colleagues wrote. Among studies that evaluated the effects of selenium without other nutrients, selenium measured in plasma, serum, red blood cells or cerebrospinal fluid increased among participants who received the mineral while remaining essentially the same or lower in the control groups. The meta-analysis determined that supplementing with selenium increased selenium levels by an average of 4 times in plasma, 1.88 times in serum, 3.73 times in red blood cells and 2.18 times in cerebrospinal fluid. 

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Skip the elevator: A 15-minute walk can help your brain fight off Alzheimer’s

German Center for Neurodegenerative Disease, August 15 2022

Older people can stave off Alzheimer’s disease with a daily 15-minute walk or other physical activities, according to new research. Researchers in Germany say moderate physical activity boosts all areas of the brain, especially those involved in memory. Staying active also benefits people over 70 the most. They see the biggest increase in grey matter, compared to their “couch potato” peers. “Our study results indicate that even small behavioral changes, such as walking 15 minutes a day or taking the stairs instead of the elevator, may have a substantial positive effect on the brain and potentially counteract age-related loss of brain matter and the development of neurodegenerative diseases. In particular, older adults can already profit from modest increases of low intensity physical activity.”

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Antioxidants in fruit boosts immunity and protects thymus gland Scripps Research Institute, August 8, 2022

Eating fruit and vegetables or taking antioxidant supplements may combat one of the most harmful aspects of aging by protecting a vital immune system organ, research suggests. Scientists demonstrated how ageing sabotaged the thymus gland, weakening the immune system and putting the elderly at greater risk of infection. But the irreversible damage could be reduced by the action of antioxidants such as vitamin C. Exper

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Researchers propose new treatment to prevent kidney stones – HCA in Garcinia Cambogia

University of Houston, August 8, 2022 

 Researchers have found evidence that a natural fruit extract is capable of dissolving calcium oxalate crystals, the most common component of human kidney stones. This finding could lead to the first advance in the treatment of calcium oxalate stones in 30 years.Jeffrey Rimer, associate professor of chemical engineering at the University of Houston, was lead author of the study, published in the online edition of Nature. The work offers the first evidence that the compound hydroxycitrate (HCA) is an effective inhibitor of calcium oxalate crystal growth that, under certain conditions, is actually able to dissolve these crystals. Researchers also explain how it works. Doctors tell patients who are at risk of developing stones to drink lots of water and avoid foods rich in oxalate, such as rhubarb, okra, spinach and almonds. They often recommend taking citrate (CA), in the form of potassium citrate, a supplement that can slow crystal growth, but some people are unable to tolerate the side effects.

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Pomegranate improves synaptic function in experimental model of Alzheimer's disease

University of New South Wales August 11, 2022. 

An article published in the journal Oncotarget reports improvement in the loss of synaptic proteins that occurs with aging in association with pomegranate intake in a mouse model of Alzheimer's disease. Synapses are the connections that enable the transmission of messages between neurons. Impairment of synaptic plasticity—the ability of synapses to strengthen or weaken over time in response to variation in their activity—is one of several neurologic changes observed in Alzheimer's disease that contributes to cognitive impairment.

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Yoga May Boost Aging Brains

Hospital Israelita Albert Einstein (Brazil), August 9, 2022 

Older women who practice yoga may have greater "thickness" in areas of the brain involved in memory and attention, a small study suggests. Researchers found that even compared with other healthy, active women their age, yoga practitioners typically had greater cortical thickness in the brain's left prefrontal cortex.The findings are based on one-time brain scans of fewer than 50 women—and they do not prove that yoga, itself, altered anyone's brain structure, according to senior researcher Elisa Kozasa.

The study does add to a bigger body of evidence on yoga and brain function, said Dr. Helen Lavretsky, a researcher who was not involved in the work. "This contributes to the evidence that yoga practice has neuroplastic effects on the brain that may translate into other health benefits—like better mood and cognition," said Lavretsky, a professor-in-residence of psychiatry at the UCLA Geffen School of Medicine.

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Resveratrol: The key to reducing elderly frailty?

Universidad Pablo de Olavide (Spain) , August 11, 2022

The so-called red wine nutrient resveratrol may help maintain muscle performance and reduce frailty in the elderly, research in mice has suggested.Using 48 young, mature and old mice models, the study found resveratrol improved muscle performance in the mature and old animals but not in the young. They found resveratrol – found in grapes, red wine, walnuts, peanuts and berries – “primed” the effect of exercise by increasing endurance, coordination and strength in the old animals as well as providing higher protection against oxidative damage and an increase in the mitochondrial mass responsible for the energy-generating process essential for cell metabolism.

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Ginkgo may enhance performance, boost brain health for active men

Poznan University (Poland), August 10, 2022

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Chili peppers for a healthy gut: Spicy chemical may inhibit gut tumors

University of California, San Diego   August 1, 2022

Researchers at the University of California, San Diego School of Medicine report that dietary capsaicin — the active ingredient in chili peppers — produces chronic activation of a receptor on cells lining the intestines of mice, triggering a reaction that ultimately reduces the risk of colorectal tumors.

The receptor or ion channel, called TRPV1, was originally discovered in sensory neurons, where it acts as a sentinel for heat, acidity and spicy chemicals in the environment. TRPV1 was quickly described as a molecular ‘pain receptor.’ 

But Raz and colleagues have found that TPRV1 is also expressed by epithelial cells of the intestines, where it is activated by epidermal growth factor receptor or EGFR. EGFR is an important driver of cell proliferation in the intestines, whose epithelial lining is replaced approximately every four to six days.

“These results showed us that epithelial TRPV1 normally works as a tumor suppressor in the intestines,” said de Jong. In addition, molecular studies of human colorectal cancer samples recently uncovered multiple mutations in the TRPV1 gene, though Raz noted that currently there is no direct evidence that TRPV1 deficiency is a risk factor for colorectal cancer in humans.

The current study suggests one potential remedy might be spicy capsaicin, which acts as an irritant in mammals, generating a burning sensation in contact with tissue. 

The researchers fed capsaicin to mice genetically prone to developing multiple tumors in the gastrointestinal tract. The treatment resulted in a reduced tumor burden and extended the lifespans of the mice by more than 30 percent. The treatment was even more effective when combined with celecoxib, a COX-2 non-steroidal anti-inflammatory drug already approved for treating some forms of arthritis and pain.

“Our data suggest that individuals at high risk of developing recurrent intestinal tumors may benefit from chronic TRPV1 activation,” said Raz. “We have provided proof-of-principle.”

How Tart Cherries Reduce Inflammation and Oxidative StressNorthumbria University (UK),  August 4, 2022Michigan researchers had previously shown that a cherry-enriched diet not only reduced overall body inflammation, but also reduced inflammation at key sites (belly fat, heart) known to affect heart disease risk in the obese.This study offers further promise that foods rich in antioxidants, such as cherries, could potentially reduce inflammation and have the potential to lower disease risk.”

Two daily doses of the tart cherry concentrate was associated with significantly lower levels of interleukin-6 (IL-6) and high-sensitivity C-reactive protein (hsCRP), compared to placebo, according to findings published in Nutrients.

”This is the first study to investigate the impact of cherries on systemic inflammatory and oxidative stress induced by a series of metabolically challenging cycling bouts. Despite both groups demonstrating a similar drop off in performance and no differences in time trial performance, the results show that both oxidative stress and inflammatory responses were attenuated with Montmorency cherry concentrate supplementation versus placebo.” 

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Vitamin K protects cells

Helmholtz Zentrum München (Germany), August 5 2022

An article appearing  in Nature reported that the reduced form of vitamin K has an antioxidant effect that inhibits cell death caused by ferroptosis: an iron-dependent type of programmed cell death characterized by the oxidative destruction of cell membranes. “We identified that vitamin K, including phylloquinone (vitamin K1) and menaquinone-4 (vitamin K2), is able to efficiently rescue cells and tissues from undergoing ferroptosis,” first author Eikan Mishima announced.

Ferroptosis has been implicated in Alzheimer disease and other disorders. “Ferroptosis, a non-apoptotic form of cell death marked by iron-dependent lipid peroxidation, has a key role in organ injury, degenerative disease and vulnerability of therapy-resistant cancers,” the authors explained. “Here we show that the fully reduced forms of vitamin K—a group of naphthoquinones that includes menaquinone and phylloquinone—confer a strong anti-ferroptotic function, in addition to the conventional function linked to blood clotting.”

In the current investigation, they determined that the fully reduced form of vitamin K (vitamin K hydroquinone) is a strong antioxidant and prevents ferroptosis. “The reduced forms of Vitamin K and coenzyme Q10 are not very stable, so our finding that FSP1 can maintain them in their active (reduced) state is key to understanding how they are able to function to maintain cell viability,” coauthor Derek A. Pratt stated. 

The team found that vitamin E and three forms of vitamin K— phylloquinone, menaquinone-4 (MK4) and menadione (vitamin K3)—rescued cells that were genetically modified to undergo ferroptosis. 

3 grams of fresh salmon does wonders for high blood pressure, study reveals

Macau University of Science and Technology (China), August 9, 2022

Omega-3 carries many health benefits, and a new review suggests eating three grams of it per day is enough to lower your blood pressure. The findings include omega-3 fatty acids obtained from food or dietary supplements.

“According to our research, the average adult may have a modest blood pressure reduction from consuming about 3 grams a day of these fatty acids,” says Xinzhi Li, MD, PhD, assistant professor and program director of the School of Pharmacy at Macau University of Science and Technology in China.

The average fish oil supplement carries an average of 300 mg of omega-3 per pill. A four to five-ounce Atlantic salmon carries about three grams of omega-3 fatty acids.

“Most of the studies reported on fish oil supplements rather than on EPA and DHA omega-3s consumed in food, which suggests supplements may be an alternative for those who cannot eat fatty fish such as salmon regularly,” explains Dr. Li. “Algae supplements with EPA and DHA fatty acids are also an option for people who do not consume fish or other animal products.”

The National Institutes of Health recommends 1.1 to 1.6 grams of omega-3 fatty acids daily. The American Heart Association advises getting some of your omega-3 intake through two servings of three to four ounces of cooked fish per week.

The review combed through the data from 71 clinical trials studying the relationship between blood pressure and the omega-3 fatty acids DHA and EPA in adults with or without high blood pressure or chole

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Astonishing effects of grapes, remarkable potential for health benefits

Western New England University, August 8, 2022

Recent studies released by Dr. John Pezzuto and his team from Western New England University show “astonishing” effects of grape consumption and “remarkable” impacts on health and on lifespans.

Published in the journal Foods, one study showed that adding grapes in an amount equal to just under two cups of grapes per day to a high-fat diet, typically consumed in western countries, yielded reductions in fatty liver and extended lifespans.  Noting that these studies add an entirely new dimension to the old saying ‘you are what you eat,’ Pezzuto, who has authored over 600 scientific studies, said that the work with grapes showed actual changes in genetic expression. “That is truly remarkable.”

Adding grapes to a high-fat diet also increased levels of antioxidant genes and delayed natural death.  Acknowledging that it is not an exact science to translate years of lifespan from a mouse to a human, Pezzuto said that his best estimate is the change observed in the study would correspond to an additional 4-5 years in the life of a human.

Another study by Dr. Pezzuto and his team published in the journal Antioxidants, reported that grape consumption altered gene expression in the brain and had positive effects on behavior and cognition that were impaired by a high-fat diet. 

Frequent nut consumption associated with less inflammation

Brigham and Women’s Hospital, August 1, 2022

In a study of more than 5,000 people, investigators from Brigham and Women’s Hospital have found that greater intake of nuts was associated with lower levels of biomarkers of inflammation, a finding that may help explain the health benefits of nuts. The results of the study appear in the American Journal of Clinical Nutrition.

“Population studies have consistently supported a protective role of nuts against cardiometabolic disorders such as cardiovascular disease and type 2 diabetes, and we know that inflammation is a key process in the development of these diseases,” said corresponding author Ying Bao, MD, ScD, an epidemiologist in BWH’s Channing Division of Network Medicine. “Our new work suggests that nuts may exert their beneficial effects in part by reducing systemic inflammation.”

In the current study, the research team performed a cross-sectional analysis of data from the Nurses’ Health Study, which includes more than 120,000 female registered nurses, and from the Health Professionals Follow-Up Study, which includes more than 50,000 male health professionals. The team assessed diet using questionnaires and looked at the levels of certain telltale proteins known as biomarkers in blood samples collected from the study participants. They measured three well-established biomarkers of inflammation: C-reactive protein (CRP), interleukin 6 (IL6) and tumor necrosis factor receptor 2 (TNFR2).

After adjusting for age, medical history, lifestyle and other variables, they found that participants who had consumed five or more servings of nuts per week had lower levels of CRP and IL6 than those who never or almost never ate nuts. In addition, people who substituted three servings per week of nuts in place of red meat, processed meat, eggs or refined grains had significantly lower levels of CRP and IL6.

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B vitamins can potentially be used to treat advanced non-alcoholic fatty liver disease

Duke University Medical School, August 6, 2022

Scientists at Duke-NUS Medical School have uncovered a mechanism that leads to an advanced form of fatty liver disease—and it turns out that vitamin B12 and folic acid supplements could reverse this process.

These findings could help people with non-alcoholic fatty liver disease, an umbrella term for a range of liver conditions affecting people who drink little to no alcohol, which affects 25% of all adults globally, and four in 10 adults in Singapore. 

Non-alcoholic fatty liver disease involves fat build-up in the liver and is a leading cause of liver transplants worldwide. When the condition progresses to inflammation and scar tissue formation, it is known as non-alcoholic steatohepatitis (NASH). 

Dr. Tripathi, study co-author Dr. Brijesh Singh and their colleagues in Singapore, India, China and the US confirmed the association of homocysteine with NASH progression in preclinical models and humans. They also found that  when homocysteine attached to a protein called syntaxin 17, it blocked the protein from performing its role of transporting and digesting fat (known as autophagy, an essential cellular process by which cells remove malformed proteins or damaged organelles) in fatty acid metabolism, mitochondrial turnover, and inflammation prevention. This induced the development and progression of fatty liver disease to NASH. 

Importantly, the researchers found that supplementing the diet in the preclinical models with vitamin B12 and folic acid increased the levels of syntaxin 17 in the liver and restored its role in autophagy. It also slowed NASH progression and reversed liver inflammation and fibrosis. 

 

Decreased acetyl-L-carnitine levels associated with depression

Stanford University, July 30 2022.

 An article that in the Proceedings of the National Academy of Sciences reported a link between low levels of acetyl-L-carnitine and a greater risk of depression.

Acting on the findings of animal research conducted by lead author Carla Nasca, PhD, the researchers recruited men and women between the ages of 20 and 70 years who had been admitted to Weill Cornell Medicine or Mount Sinai School of Medicine for treatment of acute depression. Clinical assessments were conducted upon enrollment and blood samples were analyzed for levels of acetyl-L-carnitine.

In comparison with levels measured in blood samples provided by 45 demographically matched healthy men and women, acetyl-L-carnitine blood levels in depressed subjects were substantially lower. Acetyl-L-carnitine levels were lowest among depressed patients who had severe symptoms, a history of treatment resistance, or early onset disease. Having a history of childhood abuse was also associated with low acetyl-L-carnitine levels.

“We’ve identified an important new biomarker of major depression disorder,” Dr Rasgon stated. What’s the appropriate dose, frequency, duration? We need to answer many questions before proceeding with recommendations, yet. 

 

Skip the texts: Face-to-face meetings make college students happier

University of Hamburg (Germany), August 5, 2022

In a world where everyone spends more and more time with eyes fixed on their phones, new research suggests young people feel happier after socializing with friends in person rather th