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Purple potato may pack cancer prevention punch – even after cookingPennsylvania State University, September 1, 2022Anthocyanin compounds found in purple potatoes may help in the prevention of certain types of cancer, even after cooking, say researchers.

The new data, published in the Journal of Nutritional Biochemistry, tested the potential for anthocyanin-containing purple potatoes to block the growth of cancer tumours, even when they have been cooked – after previous research suggested that the polyphenols found in purple potatoes (PP) may help to battle cancer.

Led by Venkata Charepalli from Pennsylvania State University, the team used laboratory tests including in vitro cell line investigations and animal modelling to test how PP impacted colon cancer growth, and in particular, colon cancer stem cells (CSCs), which have previously been suggested to be target by dietary bioactives such as curcumin.

The team reported that their data from in vitro and mouse models suggests that baked purple-fleshed potatoes suppressed the growth of colon cancer tumours by targeting the cancer’s stem cells.

They added that there may be several substances in purple potatoes that work simultaneously, and on multiple pathways, to help kill the colon cancer stem cells, including anthocyanins and chlorogenic acid, and resistant starch.

“Our earlier work and other research studies suggest that potatoes, including purple potatoes, contain resistant starch, which serves as a food for the gut bacteria, that the bacteria can covert to beneficial short-chain fatty acids such as butyric acid,” said study senior author Professor Jairam Vanamal – also of Penn State. “The butyric acid regulates immune function in the gut, suppresses chronic inflammation and may also help to cause cancer cells to self-destruct.”

Boosting physical activity and curbing sitting time are highly likely to lower breast cancer riskBreast Cancer Association Consortium (UK), September 6, 2022Boosting physical activity levels and curbing sitting time are highly likely to lower breast cancer risk, finds research designed to strengthen proof of causation and published online in the British Journal of Sports Medicine.

The findings were generally consistent across all types and stages of the disease, reveals the Mendelian randomization study, prompting the researchers to recommend a stronger focus on exercise as a way of warding off breast cancer.

Mendelian randomization is a technique that uses genetic variants as proxies for a particular risk factor—in this case lifelong physical activity levels/sedentary behavior—to obtain genetic evidence in support of a causal relationship.

Observational studies show that physical inactivity and sedentary behavior are linked to higher breast cancer risk, but proving they cause breast cancer is another matter.

The researchers included data from 130,957 women of European ancestry: 69, 838 of them had tumors that had spread locally (invasive); 6667 had tumors that hadn’t yet done so (in situ); and a comparison group of 54,452 women didn’t have breast cancer.

Researchers estimated overall breast cancer risk, according to whether the women had or hadn’t gone through the menopause; and by cancer type (positive for estrogen or progesterone, or HER-2, or positive/negative for all 3 hormones), stage (size and extent of tumor spread), and grade (degree of tumor cell abnormality).

These case-control groups comprised: 23,999 pre/peri-menopausal women with invasive breast cancer and 17,686 women without; 45,839 postmenopausal women with breast cancer and 36,766 without.

Analysis of the data showed that a higher overall level of genetically predicted physical activity w

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Green tea EGCG backed to prevent life-threatening ‘artery explosion’

Kyoto University, August 25, 2022

 

Drinking polyphenol-packed green tea could help to prevent a deadly condition in the body's main artery, according to new research in rats.

 

Writing in the Journal of Vascular Surgery, the Japanese research team reported that polyphenols from the nation's favourite drink, green tea, could offer benefits in preventing abdominal aneurysm expansion (AAA) – a serious condition characterised by destruction of the body’s main artery. 

 

The new study from the Kyoto University team found that rats fed a green tea extract containing epigallocatechin-3-gallate (EGCG) developed AAA less frequently than rats that were not given the polyphenol.

 

"The type of polyphenol found in green tea [EGCG] has recently been shown to regenerate elastin, an essential protein that gives the artery its stretchy, yet sturdy, texture," explains Setozaki. "Considering that abdominal arterial aneurysms are caused by inflammation and the degradation of elastin components in the arterial wall, we thought drinking green tea may show promise for treatment." 

 

The results confirmed that EGCG blocked AAA progression in the rat model by preserving the aortic thickness and elastin content through regeneration of elastin.

 

“Regular green tea consumption might be advantageous for patients with a small AAA or as a prophylactic strategy for AAA,” the team suggested.

 

 

 

 

Lower potassium intake linked to premature mortality risk

University of California at Irvine, September 2 2022. 

A study reported on August 26, 2022, in the American Journal of Clinical Nutrition found a higher risk of dying during a median 5.8 to 7.8-year follow-up period in association with a lower intake of potassium. The risk was similar between individuals with normal or impaired kidney function. 

“In healthy adults, higher dietary potassium intake is recommended given that potassium-rich foods are major sources of micronutrients, antioxidants, and fiber,” Yoko Narasaki of the University of California, Irvine and colleagues explained. “Yet among patients with advanced kidney dysfunction, guidelines recommend dietary potassium restriction given concerns about hyperkalemia [elevated blood potassium—ed.] leading to malignant arrhythmias and mortality.”

The investigation included 37,893 continuous participants in the National Health and Nutrition Education Survey (NHANES, 1999–2014) whose potassium intake was calculated from 24-hour dietary recall interviews. Mortality data was collected through the end of 2014. 

Among subjects with impaired kidney function, those whose potassium intake was among the lowest one-third had a risk of dying during a median 5.8-year follow-up period that was 18% greater than those among the top third. For participants with normal kidney function, mortality risk for those among the lowest third was 17% higher during a median 7.8 years of follow-up. 

High intake of potassium primarily from plant sources was associated with lower mortality during follow-up in comparison with a low intake of the mineral from animal-dominant sources. In the group with impaired kidney function, a 24% greater risk of mortality during follow-up occurred among those who consumed a low amount of potassium paired with a high amount of protein compared to high potassium/high protein. 

“Lower dietary potassium scaled to energy intake was associated with higher mortality, irrespective of kidney function,” the authors concluded. “Further studies are needed to elucidate pathways linking potassium intake and co-existing dietary factors with survival in populations with and without chronic kidney disease.”

 

People who lack compassion for the environment are also less emotional in generalUniversity of Michigan, September 2, 2022

People who respond less emotionally to images of damage to the environment are also less emotional

Omega-3 fatty acid supplementation could help with cognitive depression

Duke University, August 27 2022. 

 

An article appearing in the Journal of the American College of Cardiology: Heart Failure reported the outcome of a pilot study that found an association between supplementation with the omega-3 fatty acids EPA and DHA and reduced cognitive depression in heart failure patients. Cognitive depression is characterized by subjective symptoms such as pessimism and sadness, while somatic depression includes physical manifestations that include fatigue and sleep disturbances.

The study included 108 patients with a major depressive disorder, chronic heart failure and low blood levels of omega-3 fatty acids. Participants received fish oil containing EPA and DHA, a high EPA supplement or a placebo daily for 12 weeks. Blood samples collected before and after treatment were evaluated for red blood cell EPA and DHA, the Omega-3 Index and other factors.

Omega-3 values increased in both the EPA/DHA and EPA only groups, while the placebo group showed little change. Higher omega-3 Index values were associated with lower cognitive depression scores. Social functioning as evaluated by a general health survey significantly improved with EPA/DHA supplementation and showed a tendency toward improvement in the high EPA group.

"This was a study in already depressed individuals, which meant the researchers are looking to high-dose (although it could have been higher) omega-3 supplements to improve depressive symptoms, like a drug," noted coauthor William S. Harris, PhD. "Generally, we think of the function of omega-3s as preventative rather than as treatment. If used as treatment, the dose must be fairly high (4 grams is a typical 'drug' dose) and blood levels must be measured.”

 

Groundbreaking Study Shows Fasting Can Slow Aging, Rebuild Immune System

University of Southern California, August 28, 2022

Cutting-edge research reveals that occasionally adopting a diet that mimics the effects of fasting may provide dramatic health benefits.

“Fasting flips a regenerative switch essentially regenerating the entire immune system. It gives the OK for stem cells to go begin proliferating and rebuild the entire system,” said Prof Valter Longo, Professor of Gerontology and the Biological Sciences at the University of California.

A study, led by USC’s Dr. Valter, revealed that a “cycles of a four-day low-calorie diet that mimics fasting (FMD) cut visceral belly fat and elevated the number of progenitor and stem cells in several organs of old mice — including the brain, where it boosted neural regeneration and improved learning and memory,” according to USC News.

Dr. Longo notes that strict fasting can be difficult for people to adhere to, and also has the potential to be dangerous, while pointing out that a fasting mimicking diet is much safer and easier.

“Strict fasting is hard for people to stick to, and it can also be dangerous, so we developed a complex diet that triggers the same effects in the body,” said Longo, Edna M. Jones Professor of Biogerontology at the USC Davis School of Gerontology and director of the USC Longevity Institute. “I’ve personally tried both, and the fasting mimicking diet is a lot easier and also a lot safer.”

The fasting mimicking diet cuts a person’s daily caloric intake over the fasting period down to 34 to 54 percent of their daily average, with a specific balance of micronutrients, fats, carbohydrates, and proteins.

In previous groundbreaking research, Longo has shown how fasting can protect immune and other cells from chemotherapy toxicity, while simultaneously starving out cancer cells. Fasting for seventy-two hours protected cancer patients against the toxic impact of chemotherapy:

“The good news is the body got rid of the parts in the system which might be damaged or old and inefficient parts, during the fasting. If you start with a system heavily damaged by chemotherapy or aging, fasting cycles can genera

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Green tea compound shows promise for treating rheumatoid arthritis

Washington State University August 25, 2022

A compound found in green tea could be an effective treatment for rheumatoid arthritis, according to the results of a new study.

Green tea being poured into a cup] EGCG – a compound found in green tea – could help treat rheumatoid arthritis, new research suggests. In the journal Arthritis and Rheumatology, researchers from Washington State University (WSU) in Spokane reveal how the compound – called epigallocatechin-3-gallate (EGCG) – reduced ankle swelling in a mouse model of the disease. Rheumatoid arthritis (RA) is a disease that affects the joints of the body, most commonly the joints of the hands, feet, wrists, elbows knees and ankles. In RA, the immune system mistakingly attacks the synovial tissues surrounding the joints, causing inflammation, swelling and pain. This can cause damage to the cartilage and bone.

Current treatments for RA include non-steroidal anti-inflammatory drugs (NSAIDS), corticosteroids and JAK inhibitors. But study leader Salah-uddin Ahmed, of the WSU College of Pharmacy, notes that some of these treatments are expensive, reduce immune system activity and can be unsuitable for long-term use. In their study, Ahmed and colleagues suggest that the compound EGCG may be a promising alternative to current treatments for RA. EGCG targets key signaling protein to reduce RA inflammation EGCG is a chemical compound that belongs to a class of flavanols known as catechins.

After giving EGCG to mouse models of RA for 10 days, the team noticed that treatment with the compound led to a significant reduction in ankle swelling. The researchers found that EGCG reduces the activity of TAK1 – a key signaling protein through which pro-inflammatory cytokines transmit their signals to trigger the inflammation and tissue damage found in RA. What is more, the team says that EGCG reduced inflammation in RA without interfering with other cellular functions – unlike some current medications for the disease. According to Ahmed, their study suggests the green tea compound may be highly effective against RA.

Antioxidant-rich pomegranate juice may aid blood sugar management for diabetics: Human data

Jordan University of Science and Technology, August 20, 2022

Daily consumption of pomegranate juice may help control blood sugar levels in type-2 diabetics, as well as improving the function of beta cells in the pancreas, say data from a human trial.

Scientists from the Jordan University of Science and Technology report that pomegranate juice at a dose of 1.5 mL per kg of body weight (or 105 mL for a 70 kg human) was associated with reductions in fasting glucose levels in type-2 diabetics.

“Studying the effects of pomegranate consumption (in a juice form) on the reduction of blood glucose levels in type-2 diabetes patients could lead to a dietary approach to control this disease,” they added. “Since there are many herbs and fruits that are easily available and of value in controlling this disease, this study may contribute to a better understanding and improved management of type 2 diabetes by the individual.”

To investigate this, they recruited 85 people with type-2 diabetes and assigned them to receive 1.5 mL of the juice per kg of body weight. Blood sugar and insulin levels, and beta cell function were assessed three hours after ingestion. (Beta-cells are found in the pancreas and their primary function is to store and release insulin.)

Results showed that pomegranate juice was associated with significantly lower fasting glucose levels (8.5 mmol/L) compared with the control participants (9.44 mmol/L). However, this result was an average for the whole cohort and about 20% of the participants did not experience this benefit.

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HEALTH NEWS

Low magnesium linked to diabetic retinopathyExercise Outweighs Genetics When It Comes To Longer LifeGuarana found to have higher antioxidant potential than green teaStudy links caesareans and cardiovascular riskBlack tea drinkers live longerUnhealthy diet during pregnancy could be linked to ADHD

Low magnesium linked to diabetic retinopathySoochow University (China), August 26 2022. 

A study reported August 22, 2022, in Biological Trace Element Research found an association between low magnesium and a higher risk of diabetic retinopathy, a major visual complication of long-term diabetes.

“Low magnesium consumption has been linked to an increased risk of type 2 diabetic mellitus,” authors Yuan Chen of Soochow University in China and colleagues noted.

The body’s tight regulation of serum magnesium makes it a poor measure of total body magnesium status. Plasma magnesium also poorly reflects the body’s true magnesium status because of the kidneys’ reabsorption of the mineral. “The magnesium depletion score (MDS) index was recently proposed as a method of measuring magnesium shortage that took into consideration the pathophysiological factors influencing the kidneys’ reabsorption capability and was proven to be more sensitive and reliable than other clinical predictors of magnesium,” Chen and associates wrote.

The study utilized data obtained from 4,308 men and women enrolled in the National Health and Nutrition Examination Survey (NHANES) 2005–2018. Diabetes was present in 10.7% of the participants. Dietary questionnaire responses were used to estimate the amount of magnesium consumed each day. 

Greater magnesium intake and lower magnesium depletion scores were associated with a decreased risk of diabetic retinopathy. A high amount of magnesium intake was associated with a reduced risk of diabetic retinopathy when the magnesium depletion score was at a middle level or lower.

“Our research indicates that magnesium deficiency predicts a higher risk of diabetic retinopathy in diabetic individuals and that magnesium supplementation may reduce the risk of diabetic retinopathy,” they concluded.

 

 

Exercise Outweighs Genetics When It Comes To Longer LifeUniversity of California at San Diego, August 26, 2022

If living into your 90s seems to run in the family, don’t just assume that means you will too. Our genetics make us who we are, but new research from the University of California, San Diego finds exercise trumps genes when it comes to promoting a longer life.

You don’t need a medical degree to know that forgoing physical activity in favor of stagnation isn’t the wisest choice for your health and longevity. But, certain people are genetically predisposed to live longer than others. The research team at UCSD set out to determine if such individuals don’t have to move quite as much as the rest of us to live just as long.

This research project began a decade ago. In 2012, as part of the Women’s Health Initiative Objective Physical Activity and Cardiovascular Health study (OPACH), study authors began keeping track of the physical activity habits among 5,446 older U.S. women (ages 63 or older). Subjects were tracked up until 2020, and wore a research-grade accelerometer for up to seven days. That device measured how much time they spent moving, the intensity of that physical activity, and their usual amount of sedentary time.

Sure enough, higher levels of light physical activity and moderate-to-vigorous physical activity were associated with a lower risk of dying during the tracking period. Additionally, more time spent sedentary was associated with a higher risk of mortality. Importantly, this observed connection between exercise and a longer life remained consistent even among women determined to have different levels of genetic predisposition for longevity.

“Our study showed that, even if you aren’t likely to live long based on your genes, you can still extend your lifespan by engaging in positive lifestyle behavi

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One Acupuncture Treatment Drops Blood Pressure For Over a Month Without Medication

Susan Samueli Center for Integrative Medicine and University of California, Irvine , August 21, 2022

Emerging evidence from a research study shows acupuncture may be an effective treatment for hypertension. Acupuncture regulates blood pressure, blood flow and body temperature. Patients with hypertension treated with acupuncture experienced drops in their blood pressure that lasted up to a month and a half, researchers with the Susan Samueli Center for Integrative Medicine have found.

Their work is the first to scientifically confirm that this ancient Chinese practice is beneficial in treating mild to moderate hypertension, and it indicates that regular use could help people control their blood pressure and lessen their risk of stroke and heart disease.

“This clinical study is the culmination of more than a decade of bench research in this area,” said Dr. John Longhurst, a University of California, Irvine cardiologist and former director of the Samueli Center. “By using Western scientific rigor to validate an ancient Eastern therapy, we feel we have integrated Chinese and Western medicine and provided a beneficial guideline for treating a disease that affects millions in the U.S.”

Longhurst and his UCI colleagues Dr. Peng Li and Stephanie Tjen-A-Looi conducted tests on 65 hypertensive patients who were not receiving any hypertension medication. Separated randomly into two groups, the subjects were treated with electroacupuncture – a form of the practice that employs low-intensity electrical stimulation – at different acupoints on the body.

In one group of 33 receiving electroacupuncture on both sides of the inner wrists and slightly below each knee, the researchers found a noticeable drop in blood pressure rates in 70 percent of participants – an average of 6 to 8 mmHg for systolic blood pressure (the high number) and 4 mmHg for diastolic blood pressure (the low number). These improvements persisted for a month and a half.

Also in this group, the team identified significant declines in blood concentration levels of norepinephrine (41 percent), which constricts blood vessels and increases blood pressure and glucose levels; and renin (67 percent), an enzyme produced in the kidneys that helps control blood pressure. In addition, the electroacupuncture decreased aldosterone (22 percent), a hormone that regulates electrolytes.

No consequential blood pressure changes were found in the group of 32 who received electroacupuncture at other acupoints along the forearm and lower leg.

Although the blood pressure reductions in the first cohort were relatively small – mostly in the 4-to-13-mmHg range – the researchers noted that they were clinically meaningful and that the technique could be especially useful in treating systolic hypertension in patients over 60.

“Because electroacupuncture decreases both peak and average systolic blood pressure over 24 hours, this therapy may decrease the risk for stroke, peripheral artery disease, heart failure and myocardial infarction in hypertensive patients,” Longhurst said.

Vitamin C may encourage blood cancer stem cells to dieNew York University Langone Health. August 17, 2022Vitamin C may “tell” faulty stem cells in the bone marrow to mature and die normally, instead of multiplying to cause blood cancers. This is the finding of a study led by researchers from Perlmutter Cancer Center at NYU Langone Health, and published online in the journal Cell.

Certain genetic changes are known to reduce the ability of an enzyme called TET2 to encourage stem cells to become mature blood cells, which eventually die, in many patients with certain kinds of leukemia, say the authors. The new study found that vitamin C activated

Strawberries could help reduce harmful inflammation in the colonUniversity of Massachusetts, August 20, 202

Inflammatory bowel disease (IBD) is a set of painful conditions that can cause severe diarrhea and fatigue. Treatments can include medications and surgery. But now researchers report that a simple dietary intervention could mitigate colonic inflammation and improve gut health. In this case, a strawberry—or rather, less than a cupful of strawberries—a day could help keep the doctor away.

The dietary consumption of fruits and vegetables has been associated with a lowered risk of IBD. To establish an effective and practical approach to decrease colonic inflammation in both IBD patients and the general population, Xiao and his team at the University of Massachusetts Amherst focused on strawberries due to their wide consumption. 

The researchers found that dietary consumption of whole strawberries at a dose equivalent to as low as three-quarters of a cup of strawberries per day in humans significantly suppressed symptoms like body weight loss and bloody diarrhea in mice with IBD. Strawberry treatments also diminished inflammatory responses in the mice's colonic tissue.

But decreased inflammation wasn't the strawberry's only conferred benefit during this study.  Following the dietary treatments of whole strawberries, the researchers observed a reversal of that unhealthy microbiota composition in the IBD mice. Xiao's team also obtained experimental data that indicated strawberries might impact abnormal metabolic pathways in the IBD mice, which in turn could lead to the decreased colonic inflammation they observed.

Higher diet quality relates to decelerated epigenetic aging Tufts University, August 1, 2022DNA methylation–based epigenetic age measures have been used as biological aging markers and are associated with a healthy lifespan. Few population-based studies have examined the relation between diet and epigenetic age acceleration. We aimed to investigate the relation between diet quality and epigenetic age acceleration.

We analyzed data from 1995 participants (mean age, 67 years; 55% women) of the Framingham Heart Study Offspring Cohort. Cross-sectional associations between the Dietary Approaches to Stop Hypertension (DASH) score and 3 whole-blood DNA methylation–derived epigenetic age acceleration measures—Dunedin Pace of Aging Methylation (DunedinPoAm), GrimAge acceleration (GrimAA), and PhenoAge acceleration (PhenoAA)—were examined.Conclusions:  Higher diet quality is associated with slower epigenetic age acceleration, which partially explains the beneficial effect of diet quality on the lifespan. Our findings emphasize that adopting a healthy diet is crucial for maintaining healthy aging.

Feeling anxious or blue? Ultra-processed foods may be to blameFlorida Atlantic University, August 25, 2022

Do you love those sugary-sweet beverages, reconstituted meat products and packaged snacks? You may want to reconsider based on a new study that explored whether individuals who consume higher amounts of ultra-processed food have more adverse mental health symptoms.

Researchers from Florida Atlantic University's Schmidt College of Medicine and collaborators explored a nationally representative sample of the United States population to determine if individuals who consume high amounts of ultra-processed foods report significantly more adverse mental health symptoms including depression, anxiety and mentally unhealthy days.  They measured mild depression, number of mental unhealthy days and number of anxious days in 10,359 adults 18 and older from the U.S. National Health and Nutrition Examination Survey.

Results of the study, published in the journal Public Health Nutrition, showed that individuals who consumed the most ultra-processed foods as compared with those who consumed the least amount had statistically significant increases in the adverse mental health symptoms of mild depression, "mentally unhealthy days" and "

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Tea, flavonoid intake associated with lower fracture riskUniversity of Western Australia, August 14 2022

An article published in the American Journal of Clinical Nutrition adds more evidence to a protective effect for tea drinking against the development of osteoporotic fractures in women.

The study included 1,188 women over the age of 75 years enrolled in the Calcium Intake Fracture Outcome Study, which evaluated the effect of calcium supplementation in the prevention of osteoporosis. Tea intake was assessed at the beginning of the study and at two and five years. The subjects were followed for ten years, during which 288 women developed an osteoporotic fracture, including 212 major fractures and 129 hip fractures.

Among women whose intake of tea was three cups or higher per day, there was a 30% decrease in the risk of any osteoporotic fracture in comparison with those whose intake was a cup or less per week. Subjects whose flavonoid intake from tea and foods was among the highest one-third of subjects had risks of osteoporotic fracture, major osteoporotic fracture and hip fracture that were 35%, 34% and 42% lower than those whose intake was among the lowest third. When individual flavonoids were analyzed, higher consumption of flavonols, flavan-3-ols and flavones was significantly associated with a protective effect against osteoporotic fracture risk.

“The current study found that flavonoid intake was associated with a reduced risk of hip, major, and all osteoporotic fractures in elderly women,” write authors Gael Myers and colleagues. “The major flavonoids found in tea, flavan-3-ols, and flavonols were also associated with a reduced fracture risk, providing evidence for the role of tea flavonoids in promoting bone health.”

Skipping breakfast may increase chance of kids and teens developing psychosocial health problemsUniversity of Castilla-La Mancha (Spain), August 23, 2022

Young people who eat healthy breakfasts at home have better psychosocial health, shows a recent study in Frontiers in Nutrition. While previous research has reported the important role of a nutritious breakfast, this is the first study to look at the reported effects of whether kids eat breakfast, as well as where and what they eat. These results provide valuable insights and recommendations for parents and their children.

“Our results suggest that it is not only important to eat breakfast, but it’s also important where young people eat breakfast and what they eat,” said first author Dr. José Francisco López-Gil of the University of Castilla-La Mancha in Cuenca, Spain. “Skipping breakfast or eating breakfast away from home is associated with increased likelihood of psychosocial behavioral problems in children and adolescents. Similarly, consumption of certain foods/drinks are associated with higher (eg, processed meat) or lower (eg, dairies, cereals) odds of psychosocial behavioral problems.”

Among the most important results, López-Gil and the team found that eating breakfast away from home was nearly as detrimental as skipping the meal entirely. The authors suggest that this may be because meals away from home are frequently less nutritious than those prepared at home.

The results also showed that coffee, milk, tea, chocolate, cocoa, yogurt, bread, toast, cereals, and pastries were all associated with lower chances of behavioral problems. Surprisingly, eggs, cheese, and ham were linked with higher risks of such issues.

Amla Tea in Hospitalized Patients With COVID-19Ahvaz Jundishapur University of Medical Sciences (Iran), August 14, 2022Randomized, double-blind, placebo-controlled trial to evaluate whether the addition of Phyllanthus emblica (amla) tea to standard protocols affects lung function, symptomology, and length of hospital stay in a population of hospitalized patients with Covid-19While amla tea did not reduce the severity of lung involvement nor sig

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Vitamin D May Protect Against Autoimmune DiseasesBrigham and Women’s Hospital, August 3, 2022To investigate the effect of vitamin D and fish oil supplementation, alone and in combination, on the 5-year incidence of new-onset autoimmune disease in an older populationDesign; Randomized, double-blind, placebo-controlled trial with a 2-by-2 factorial designParticipants: This study included 25,871 participants, of whom 12,786 were men aged ≥50 years (51%) and 13,085 were women aged ≥55 years. The mean age was 67.1 years.Intervention: Participants were randomized to 1 of 4 groups:Omega-3 fatty acid (1,000 mg/day; 460 mg eicosapentaenoic acid and 380 mg docosahexaenoic acid) and vitamin D supplementation (2,000 IU/day)Omega-3 fatty acid (1,000 mg/day) and placeboVitamin D supplementation (2,000 IU/day) and placeboPlaceboKey Findings

In older adults, supplementing with daily vitamin D (2,000 IU) for 5 years decreased the incidence of autoimmune disease by 22%. Omega-3 fatty acid supplementation alone decreased incidence of autoimmune disease by 15% but was not statistically significant. The combination of vitamin D and omega-3 did not appear to have significant added benefit. Omega-3 supplementation alone did appear to be more beneficial for prevention of autoimmune disease onset in those with a positive family history and also appeared to have more impact in the later years of the study.

It does appear that vitamin D supplementation, with or without omega-3 supplementation, decreases the incidence of new-onset autoimmune disease in people aged more than 55 years. The study did an excellent job ensuring regimen adherence with the use of biomarkers.

Bitter Orange: Another Tool to Improve SleepAhvaz Jundishapur University of Medical Sciences (Iran), August 13, 2022To determine whether inhalation of Citrus aurantium (bitter orange) daily over 4 weeks would improve the sleep of postmenopausal women. The bitter orange essential oil used in this study, made from the flowers, is also called neroli oil. The main constituent (35%) is linalool, which has several properties, including anxiolytic, antioxidant, antimicrobial, cytotoxic, and antidiabetic.8 Linalool is present in lavender essential oil also.Inhalation of Citrus aurantium for 5 minutes, twice daily, 4 days a week for 4 weeks resulted in a significant improvement in sleep for postmenopausal women. Sleep complaints affect a significant portion of this subpopulation.Participants: Eighty postmenopausal women, aged 45 to 60 years, participated in this study. Inclusion criteria were the ability to read and write, cessation of menses for 12 months or more, 5 or more on the Pittsburgh Sleep Quality Index questionnaire, no medical or mental disorder, available medical records, no alcohol, and no stressful events in the 6 months prior.Intervention: Participants placed 2 drops of oil on their forearm and inhaled the aroma from a distance of 30 cm away with normal breathing for 5 minutes twice daily (10 am and 10 pm). The treatment group received 10% Citrus aurantium oil (mixed in odorless almond oil diluted with propylene glycol), while the control group received odorless almond oil, which was also diluted with propylene glycol. They inhaled the aroma 4 consecutive days each week for 4 weeks.Key Findings: The postmenopausal women who used the Citrus aurantium oil had a statistically significant improvement in their subjective sleep, with the PSQI dropping from 12.08 to 5.75Inhalation aromatherapy for sleep has a historical precedent, and research in this area is accumulating. Reviews have found evidence for use of bergamot, cedar, lemon, rose, sweet orange, valerian, and other essential oils. When the essential

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Higher vitamin C levels associated with lower mortality risk during 16-year period

Chinese Academy of Medical Sciences, August 20 2022

A study reported in the Journal of Epidemiology and Community Health has uncovered an association between higher plasma vitamin C levels and a lower risk of mortality during more than 16 years of follow-up. 

The study included 473 men and 475 women between the ages of 53 and 84. 

Among subjects whose plasma vitamin C concentrations were among the top 25%, the adjusted risk of dying from any cause during follow-up was 25% lower than the risk experienced by subjects whose vitamin C levels were among the lowest quarter. Those whose plasma vitamin C levels were among the highest 25% had an adjusted risk of dying from cancer or stroke that was 28% lower and a risk of dying from heart disease that was 35% lower than subjects whose levels were lowest. 

When subjects with low vitamin C levels (defined as 28 micromoles per liter or below) and normal levels (greater than 28 micromoles per liter) were compared, a normal level was associated with a 23% lower risk of premature mortality and a 38% lower risk of dying from heart disease, in comparison with low levels. 

As a possible reason for their findings, Shao-Ming Wang and colleagues note that oxidative stress is lowered by vitamin C. Oxidative stress can promote endothelial dysfunction that underlies heart disease by increasing inflammation and lipid peroxidation and decreasing nitric oxide availability. Oxidative stress also causes DNA damage associated with cancer.

Pomegranate-cocoa blend helps improve aging men’s symptoms

Shetty Hospital (India), August 19 2022. 

A study published  in the International Journal of Medical Science found benefits for supplementing with a combination of extracts of Punica granatum (pomegranate) fruit rind and Theobroma cocoa seed extracts in middle-aged men.

Previous research that investigated the effects of a blend of extracts of pomegranate fruit rind and cocoa seed in young men resulted in increases in serum and free testosterone levels as well as muscle strength and size. The current study included 120 men between the ages of 36 to 55 years who received 200 mg or 400 mg of pomegranate-cocoa extract or a placebo for 8 weeks. All participants were assigned to a program consisting of 30 minutes of walking per day for 5 days per week. 

At the end of the 7-week period, both doses of pomegranate-cocoa extracts were associated with significant improvement in aging males’ symptom scores, free and total testosterone levels, strength and perceived stress compared to the beginning of the study and to the placebo group. 

The authors concluded that pomegranate-cocoa “is a well-tolerated, safe, and effective nutraceutical blend that boosts sexual function, testosterone level, and psychological and general well-being in aging males.”

Placebo effect demonstrates healing power of the mind

Harvard Medical School, August 13, 2022

 Experts at Harvard Medical School advocate that the placebo effect be received with more positivity, rather than viewed as a deceptive or inaccurate measure designed to test health.  They conclude that the power of thought can be extremely effective in helping people heal, focusing on physiological changes that have been linked to the placebo effect.The placebo effect involves someone being given medicine that is actually typically nothing more than a sugar pill which does not contain active ingredients. Many times, patients receiving a placebo who are in need of healing a certain condition report feeling significantly better, if not altogether healed.The experts at Harvard explain that improvements may take place because of the anticipated response that a person expects when given medication. The university’s litera