The Gary Null Show

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Blackcurrant nectar shows exercise benefits for college students: Study

University of the Incarnate Word, September 14, 2022

Daily consumption of blackcurrant nectar for eight days may reduce muscle damage and inflammation after exercise, according to a new study from scientists at the University of the Incarnate Word in San Antonio, Texas.

Sixteen ounces per day of the blackcurrant nectar were associated with reductions in the activity of creatine kinase, a blood marker of muscle damage, by 6.7%, compared to 82% increases in activity in the placebo group 48 hours after exercise, report the researchers in the Journal of Dietary Supplements .

Researchers led by Alexander Hutchison, PhD, also report that levels of the inflammatory compound interleukin-6 decreased after exercise in participants in the blackcurrant group, compared with increases seen in the placebo group.

“In partial support of our primary hypotheses, we found that consumption of black currant nectar for four days before and three days after a bout of eccentric leg exercise significantly reduced circulating markers of muscle damage while maintaining circulating antioxidant capacity,” they wrote in their paper. “Although pain scores in the blackcurrant nectar group returned to baseline a day earlier than the placebo group, there were no significant differences observed between groups at any time point after exercise.

The study included 16 college students randomly assigned to consumer either the blackcurrant nectar beverage (CurrantC provided by CropPharms from Staatsburg, NY) or placebo twice a day for eight days. On day 4 the participants performed a bout of knee extension exercises, and blood samples taken 24, 48, and 96 hours after the exercise.

Results showed that ORAC levels in the blood significantly decreased in the placebo group, while no significant decreases from the baseline values were observed in the blackcurrant group. In addition, significant differences between the groups were observed for IL-6 levels 24 hours after exercise, while significant differences were observed in creatine kinase activity between the groups after 48 and 96 hours..

How does what we eat affect our health span and longevity? It’s a complex, dynamic systemColumbia University’s Mailman School of Public Health, September 21, 2022

How does what we eat affect how we age? The answer to this relatively concise question is unavoidably complex, according to a new study at the Butler Columbia Aging Center at Columbia University Mailman School of Public Health. The findings are published online in the journal BMC Biology.

While most analyses had been concerned with the effects of a single nutrient on a single outcome, a conventional, unidimensional approach to understanding the effects of diet on health and aging no longer provides us with the full picture: A healthy diet must be considered based on the balance of ensembles of nutrients, rather than by optimizing a series of nutrients one at a time. Until now little was known about how normal variation in dietary patterns in humans affects the aging process.

“”This study therefore provides further support to the importance of looking beyond ‘a single nutrient at a time’ as the one size fits all response to the age-old question of how to live a long and healthy life.” Cohen also points that the results are also concordant with numerous studies highlighting the need for increased protein intake in older people, in particular, to offset sarcopenia and decreased physical performance associated with aging.

The researchers analyzed data from 1,560 older men and women, aged 67-84 years selected randomly from the Montreal, Laval, or Sherbrooke areas in Quebec, Canada, who were re-examined annually for three years

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Antioxidants protect against cartilage damageSkeletal Biology and Engineering Research Center (Belgium), September 12 20228.

An article appearing in Science Translational Medicine adds evidence to the role of antioxidants in protecting the body’s cartilage from the damage that contributes to osteoarthritis.

Acting on the finding that the protein ANP32A, which is involved in a number of processes in the body, was downregulated in osteoarthritic cartilage in mice and humans, Frederique Cornelis of the Skeletal Biology and Engineering Research Center in Belgium and colleagues discovered that ANP32A protects against oxidative damage in the joints, thereby helping to prevent the development of osteoarthritis and its progression. It was determined that ANP32A increases levels of the enzyme ATM, a regulator of the cellular oxidative defense, in response to oxidative stress in joint cartilage.

The discovery suggests that antioxidant therapies could help protect against further damage in patients with osteoarthritis, as well as providing a benefit in other disorders. Administration of the antioxidant N-acetylcysteine (NAC) to the drinking water of mice that were deficient in ANP32A was shown to decrease cartilage damage and arthritis symptoms. It was additionally revealed that ANP32A deficiency was associated with osteopenia and a neurologic disease known as cerebellar ataxia in mice and that NAC helped with these conditions.

“Aging, a key risk factor for the development of osteoarthritis, is associated with elevated oxidative damage of DNA, proteins, and lipids, and accumulating evidence indicates that oxidative stress is a major physiological inducer of aging,” the authors write. “We observed reduced expression of ANP32A in aged mouse cartilage and in human cartilage from patients with osteoarthritis, and we showed that Anp32a-deficient mice develop spontaneous osteoarthritis upon aging. Thus, ANP32A can be considered as a key coordinator of oxidative stress and aging in joints.”

“Our findings indicate that modulating ANP32A signaling could help manage oxidative stress in cartilage, brain, and bone with therapeutic implications for osteoarthritis, neurological disease, and osteoporosis,” they conclude.

Consuming Soy Peptide May Reduce Colon Cancer Metastasis

University of Illinois, September 18, 2022

After a recent University of Illinois study showed that injection of the soy peptide lunasin dramatically reduced colon cancer metastasis in mice, the researchers were eager to see how making lunasin part of the animals’ daily diet would affect the spread of the disease.

“In this new study, we find that giving lunasin orally at 20 mg/kg of body weight reduced the number of metastatic tumors by 94 percent — we went from 18 tumors to only one. And that was done using lunasin alone; no other type of therapy was used,” said Elvira de Mejia, a U of I professor of food chemistry and food toxicology.

“We learned in that study that lunasin can penetrate the cancer cell, cause cell death, and interact with at least one type of receptor in a cell that is ready to metastasize,” said Vermont Dia, a postdoctoral associate in the de Mejia laboratory.

Using mice that had been injected with human colon cancer cells, the scientists began by feeding the animals 8 mg/kg of lunasin daily, which reduced the number of new tumors in the liver by 55 percent. They increased the dose five times, at last achieving a 94 percent reduction in tumors at 20 mg/kg of lunasin.

“We were very impressed by the reduction, but the results were short of statistical significance from the control group. More animals are needed to strengthen the power of the analysis. It’s a small study but very promising

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Meta-analysis finds less fatigue with CoQ10 supplementationNational Yang Ming Chiao Tung University (Taiwan), September 16 2022.

The results of a systematic review and meta-analysis of clinical trials, published in Frontiers in Pharmacology, support an anti-fatigue effect among individuals who supplemented with coenzyme Q10.

“Coenzyme Q10 (CoQ10) is a popular nutritional supplement and a lipid-soluble antioxidant that is endogenously produced by the human body,” authors I-Chen Tsai of National Yang Ming Chiao Tung University and associates observed. “CoQ10 supplementation has been successfully applied for reducing fatigue in patients with various conditions, including chronic fatigue and fibromyalgia, as well as in healthy subjects.”

For their analysis, Tsai colleagues identified 13 randomized, controlled trials that compared fatigue scores of participants who received CoQ10 or a placebo. The trials included a total of 1,126 participants.

Analysis of the 13 trials showed a consistent significant effect for CoQ10 in reducing fatigue. When trials that included healthy participants were analyzed separately from trials that included patients with fatigue-associated diseases, both supplemented populations showed decreases in fatigue, however the effects were significant among the unhealthy participants, who may have more severe CoQ10 depletion. Higher CoQ10 doses and longer duration of supplementation were correlated with increased fatigue reduction.

The anti-fatigue effect of CoQ10 is unsurprising, given its role in energy production. Chronic fatigue syndrome patients have lower plasma levels of CoQ10 in comparison with healthy subjects. While the body makes some CoQ10, the authors remarked that studies have provided evidence that supplementing with CoQ10 does not affect the body’s synthesis of the coenzyme.

Researchers identify a potential new approach with a dietary supplement to treat HER2 positive breast cancerMayo Clinic, September 9, 2022

Researchers at Mayo Clinic have identified an important new pathway by which HER2 positive breast cancers grow and have discovered that a dietary supplement called cyclocreatine may block the growth of HER2 positive breast cancer. Their findings were published in Cell Metabolism.

“The HER2 receptor tyrosine kinase, which functions as an ‘on’ or ‘off’ switch in cellular functions, is a key driver of breast cancer, and is overexpressed in about a quarter of all breast cancers,” says Taro Hitosugi, Ph.D., a pharmacologist at Mayo Clinic and corresponding author of the paper.

Dr. Hitosugi and his colleagues decided to explore ways to resolve an unmet clinical need. Their strategy was to develop a treatment to target tumor mitochondrial energy metabolism, which is the process cancer cells use to manipulate energy during cell metabolism in order to grow.

Dr. Hitosugi and his colleagues discovered that cyclocreatine, a dietary supplement used in sports drinks, effectively targets mitochondrial creatine kinase 1 enzyme and reduces cancer growth without toxicity. This finding was confirmed in mice models where a patient-derived, trastuzumab-resistant HER2 positive tumors were administered to the mice.

“Mitochondrial creatine kinase 1 may be a new drug target for the treatment of HER2 positive breast cancer,” says Matthew Goetz, M.D., director of the Mayo Clinic Breast Cancer research program. “Future clinical trials will be necessary to determine the effectiveness of this drug for HER2 positive breast cancer resistant to standard therapies.”

Excessive smartphone screen time linked to earlier puberty onsetGazi University (Turkey), September 16, 2022

Exposure to blue light, via regular use of tablets and smartphones, ma

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Astragulus found to inhibit breast cancer cell proliferationFujian University of Traditional Medicine (China), September 8, 2022Huang qi (Astragalus) is one of the fundamental herbs in traditional Chinese medicine, with earliest records of its use dating back over 2,000 years ago. Now, a study in BMC Complementary and Alternative Medicine has found that astragulus is also able to prevent the spread of breast cancer cells in the body.

In the study, researchers from the Fujian University of Traditional Chinese Medicine in China looked at how astragulus extract can affect breast cancer cells and the process behind this biological effect. They also looked at the primary isoflavones in the extract, as well as its anti-proliferative activity on three breast cancer lines: MCF-7 (ER+), SK-BR-3 (HER2+) and MDA-MB-231 (triple-negative). They did this by exposing these breast cancer cells to the extract for 48 hours.

In addition, they examined the effect of astragulus extract on phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) signaling pathways, a primary intracellular signaling pathway that contributes to cell proliferation, growth, migration, metabolism, and apoptosis.

The results of the study showed that the treatment of astragulus exhibited anti-proliferative activity on breast cancer cells. Furthermore, the therapy promoted the death of breast cancer cells. These suggested that it’s ability to inhibit breast cancer cell growth was linked to its ability to inhibit PI3K/Akt/mTOR activity. Moreover, the researchers found that the Huang qi extract contains four types of isoflavones, such as campanulin, ononin, calycosin, and formononetin, which contributed to the inhibitory effect of Huang qi extract on breast cancer cells proliferation.

Vitamin D supplementation could help critically ill patientsUniversity Hospital Würzburg (Germany) September 12 2022.

Findings from a review and meta-analysis reported in Critical Care suggest that providing critically ill patients with vitamin D supplements may improve some clinical outcomes, including survival.

“Upon ICU admission, the majority of patients have significantly reduced 25-hydroxyvitamin D levels, which remain significantly reduced over the entire ICU length of stay,” Johannes Menger and colleagues wrote. “In these patients, significantly reduced vitamin D (25-hydroxyvitamin D) serum levels are frequent and independently associated with higher incidence and severity of sepsis.”

Sixteen randomized, controlled trials that evaluated vitamin D supplementation’s association with mortality were identified.

Vitamin D supplementation was associated with a 22% lower risk of overall mortality in comparison with a placebo or standard care. Among studies that reported 28-day mortality, vitamin D supplementation was associated with a trend toward lower a lower risk. Receiving vitamin D by injection or intravenously had the strongest effect. Patients who received vitamin D spent an average of 3.13 days less in the ICU and 5 fewer days on a ventilator than those who received a placebo.

“The results of this systematic review and meta-analysis suggest that vitamin D supplementation may be associated with reduced overall mortality in critically ill patients,” they concluded.

Natural compound could reduce breast cancer risk in some women

Luteolin may inhibit growth of human breast cancer cells in postmenopausal women taking hormone replacement therapy

University of Missouri-Columbia, September 9, 2022

More than 100 women die from breast cancer every day in the United States. The odds increase in postmenopausal women who have taken a combined estrogen and progestin hormone replacement therapy; these women also have

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Higher omega-3 levels linked to better sleep

University of British Columbia, September 14 2022. 

Having higher blood concentrations of the omega-3 polyunsaturated fatty acids eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and docosapentaenoic acid (DPA) was found to be associated with a reduction in excessive sleep in an analysis reported in 2022 in the American Journal of Clinical Nutrition.

Sleep duration of over 9 hours per night has been correlated with an increased risk of cardiovascular disease and premature mortality from all causes.

The analysis included 21,653 participants in 12 studies for whom information was available concerning sleep duration and/or difficulty falling asleep and blood levels of the omega-3 fatty acids EPA, DHA, ALA and, when available, DPA, and the omega-6 fatty acids AA and LA.

When men and women whose fatty acid levels were among the lowest 20% of participants were compared to those whose levels were among the top 20%, individuals whose DHA intake was highest had a 22% lower risk of excessive sleep. Being among those who had the highest intake of EPA plus DHA and DPA was associated with a 24% lower risk. The authors noted that DHA’s role in regulating melatonin production helps regulate sleep. 

Twice-daily nasal irrigation reduces COVID-related illness, death

Medical College of Georgia at Augusta University, September 13, 2022

Starting twice daily flushing of the mucus-lined nasal cavity with a mild saline solution soon after testing positive for COVID-19 can significantly reduce hospitalization and death, investigators report.

They say the technique that can be used at home by mixing a half teaspoon each of salt and baking soda in a cup of boiled or distilled water then putting it into a sinus rinse bottle is a safe, effective and inexpensive way to reduce the risk of severe illness and death from coronavirus infection that could have a vital public health impact. 

“By giving extra hydration to your sinuses, it makes them function better.

“We found an 8.5-fold reduction in hospitalizations and no fatalities compared to our controls,” says senior author Dr. Richard Schwartz, chair of the MCG Department of Emergency Medicine. “Both of those are pretty significant endpoints.”

The study appears to be the largest, prospective clinical trial of its kind and the older, high-risk population they studied—many of whom had preexisting conditions like obesity and hypertension—may benefit most from the easy, inexpensive practice, the investigators say.

They found that less than 1.3% of the 79 study subjects age 55 and older who enrolled within 24-hours of testing positive for COVID-19 between Sept. 24 and Dec. 21, 2020, experienced hospitalization. No one died. 

Researchers know that the more virus that was present in your body, the worse the impact. “One of our thoughts was: If we can rinse out some of the virus within 24 hours of them testing positive, then maybe we can lower the severity of that whole trajectory,” she says, including reducing the likelihood the virus could get into the lungs, where it was doing permanent, often lethal damage to many.

Baxter says the nasal irrigation with saline helps decrease the usual robust attachment. Saline appears to inhibit the virus’ ability to essentially make two cuts in itself, called furin cleavage, so it can better fit into an ACE2 receptor once it spots one.

Participants self-administered nasal irrigation using either povidone-iodine, that brown antiseptic that gets painted on your body before surgery, or sodium bicarbonate, or baking soda, which is often used as a cleanser, mixed with water that had the same salt concentration normally found in the body.

Those who completed nasal irrigation twice

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Onion extracts lower blood pressure for hypertensives: study

University of Bonn (Germany), September 7, 2022

Taking onion skin-derived food supplements of the flavonol quercetin can lower blood pressure for people with hypertension, according to a new study published in the British Journal of Nutrition.

Researchers from the University of Bonn in Germany conducted a double-blind study on 68 overweight or obese volunteers with pre-hypertension or stage 1 hypertension, giving them either a quercetin-rich onion skin extract supplement or a placebo for six weeks.

While the subjects who were not classed as having high blood pressure did not show significant changes, those with high blood pressure saw positive results.

“Supplementation with 162 mg/d quercetin from onion skin extract lowers [ambulatory blood pressure] in patients with hypertension, suggesting a cardioprotective effect of quercetin. The mechanisms responsible for the [blood pressure]-lowering effect remain unclear,” wrote the study’s authors.

Quercetin is an antioxidant commonly found in plants, including onions, kale, apple skins, berries, citrus fruits and tea.

Participants with hypertension saw their systolic blood pressure fall an average of 3.6 mmHg, which the authors suggested “would be clinically meaningful when considered at the population level, particularly in view of the large population of people with pre-hypertension and stage I hypertension”.

The dose of 162 mg per day of quercetin-rich onion skin extract, in the form of three 54 mg capsules, was identified as being approximately 10 to 15 times the normal daily quercetin intake for people in the European Union. The study excluded people who consumed high levels of quercetin in their normal diets.

Older adults with regular activity routines are happier and do better on cognitive tests, study findsUniversity of Pittsburgh, September 12, 2022

Older adults who consistently get up early and remain active throughout the day are happier and perform better on cognitive tests than those with irregular activity patterns, according to a new study led by University of Pittsburgh researchers.

The findings, published online in JAMA Psychiatry, suggest that patterns of activity—not just activity intensity—are important for healthy aging and mental health.

“There’s something about getting going early, staying active all day and following the same routine each day that seems to be protecting older adults,” said lead author Stephen Smagula, Ph.D., assistant professor of psychiatry and epidemiology at Pitt. “What’s exciting about these findings is that activity patterns are under voluntary control, which means that making intentional changes to one’s daily routine could improve health and wellness.”

To learn more about daily activity patterns in U.S.-based older adults and identify links with mental health and cognition, Smagula and his team recruited 1,800 senior citizens aged over 65. Participants wore accelerometers—movement-detecting devices often found in smartphones and exercise trackers—on their wrists for seven days to measure activity, and they completed questionnaires to assess depression symptoms and cognitive function.

The analysis showed that 37.6% of participants rose early in the morning, stayed active throughout the day and had consistent daily routines.

Another group comprising 32.6% of participants similarly had consistent daily patterns but the participants were active for an average of just 13.4 hours each day because they rose later in the morning or settled down earlier in the evening. This group had more depression symptoms and poorer cognition t

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Dr. Katarina Lindley is a board-certified family physician with a direct primary care practice in Texas.  Having grown up in Croatia war-torn Yugoslavia, she traveled and lived in Western Europe before arriving in the US to attend medical school in Florida. In addition to her clinical practice Kat has been active in medical activism to improve our broken healthcare system.  Kat is an active member in several medical and civic organizations including the American Academy of Physicians and Surgeons and the American College of Osteopathic Family Physicians. She is on the Steering Committee of World Council for Health, a global network of over 130 organizations in 40 countries taking a lead in addressing the failures of government health ministries failures in dealing with the Covid-19 pandemic. ahe has testified in various health committees in the USA and internationally, including giving testimony at the FDA against the scientific rationale to vaccinate children with the Covid vaccines and boosters. Kat’s website is KatLindleyDO.com and WorldCouncilForHealth.org

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Frequent nut consumption associated with less inflammation

Brigham and Women’s Hospital, September 1, 2022

In a study of more than 5,000 people, investigators from Brigham and Women’s Hospital have found that greater intake of nuts was associated with lower levels of biomarkers of inflammation, a finding that may help explain the healthbenefits of nuts. The results of the study appear in the American Journal of Clinical Nutrition.

“Population studies have consistently supported a protective role of nuts against cardiometabolic disorders such as cardiovascular disease and type 2 diabetes, and we know that inflammation is a key process in the development of these diseases,” said corresponding author Ying Bao, MD, ScD, an epidemiologist in BWH’s Channing Division of Network Medicine. “Our new work suggests that nuts may exert their beneficial effects in part by reducing systemic inflammation.”

Previously Bao and her colleagues observed an association between increased nut consumption and reduced risk of major chronic diseases and even death, but few prospective cohort studies had examined the link between nut intake and inflammation. In the current study, the research team performed a cross-sectional analysis of data from the Nurses’ Health Study, which includes more than 120,000 female registered nurses, and from the Health Professionals Follow-Up Study, which includes more than 50,000 male health professionals. The team assessed diet using questionnaires and looked at the levels of certain telltale proteins known as biomarkers in blood samples collected from the study participants. They measured three well-established biomarkers of inflammation: C-reactive protein (CRP), interleukin 6 (IL6) and tumor necrosis factor receptor 2 (TNFR2).

After adjusting for age, medical history, lifestyle and other variables, they found that participants who had consumed five or more servings of nuts per week had lower levels of CRP and IL6 than those who never or almost never ate nuts. In addition, people who substituted three servings per week of nuts in place of red meat, processed meat, eggs or refined grains had significantly lower levels of CRP and IL6.

Peanuts and tree nuts contain a number of healthful components including magnesium, fiber, L-arginine, antioxidants and unsaturated fatty acids such as α-linolenic acid. Researchers have not yet determined which of these components, or if the combination of all of them, may offer protection against inflammation, but Bao and her colleagues are interested in exploring this further through clinical trials that would regulate and monitor diet.

“Much remains unknown about how our diet influences inflammation and, in turn, our risk of disease,” said Bao. “But our study supports an overall healthful role for nuts in the diet and suggests reducing inflammation as a potential mechanism that may help explain the benefits of nuts on cardiometabolic diseases.”

Blueberry extract could help fight gum disease and reduce antibiotic use

Laval University (Quebec), September 2, 2022

Gum disease is a common condition among adults that occurs when bacteria form biofilms or plaques on teeth, and consequently the gums become inflamed. Some severe cases, called periodontitis, call for antibiotics. But now scientists have discovered that wild blueberry extract could help prevent dental plaque formation. Their report in ACS’ Journal of Agricultural and Food Chemistry could lead to a new therapy for periodontitis and a reduced need for antibiotics.

Many people have had some degree of gum inflammation, or gingivitis, caused by dental plaque. The gums get red and swollen, and they bleed easily. If left unchecked, the condition can progress to periodontitis. The plaque hardens into tartar, and the infection ca