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Stomach cancer cells halted with whole tomato extracts

Sbarro Institute for Molecular Medicine at Temple University  October 10, 2022

The Mediterranean diet has become regarded as highly beneficial to overall health, maintaining ideal weight and a reduced risk of cancer plus many other chronic disease conditions. One of the staples of this diet is tomatoes, especially the low-acid varieties that are grown in Italy and its impact on cancer risk is quite interesting.

Recent research by the Sbarro Institute for Molecular Medicine at Temple University in Philadelphia, Pa. has confirmed that two tomato cultivars grown in Southern Italy inhibit both malignant features and cellular growth in stomach cancer cells.

For the study, whole tomato lipophilic extracts were analyzed for their ability to fight and diminish neoplastic features of stomach cancer cells. Both the Corbarino and San Marzano tomato varieties were found to inhibit the cloning behavior of malignant cancer cells as well as impede their growth.

When tomato extracts were used on stomach cancer cells, key processes related to cell development, migration and proliferation were inhibited. The tomato extracts ultimately induced apoptosis, or cancer cell death in cancer cells. The study results were published in the Journal of Cellular Physiology.

Significantly, the tomato extracts contributed to the movement of cancer cells away from the primary tumor, which resulted in their death. These anticancer effects weren’t related to just one particular compound such as lycopene. Instead, the whole tomato seemed to contribute to its anticancer effects.

Previous studies had suggested the carotenoid compound lycopene, which creates the orange-red color of tomatoes, is what fights cancer cells. While lycopene may still be a major factor, the entire tomato seemed to have a highly potent effect against cancer.

Amino Acid Arginine Found As Effective As Drugs For Glucose Metabolism And DiabetesUniversity of Copenhagen & University of Cincinnati, October 9, 2022 If you suffer from type 2 diabetes, you may want to consider snacking on nuts to treat the condition. Supplementation with the amino acid arginine, commonly found in almonds and hazelnuts, could help to improve glucose metabolism by as much as 40%, according to new research in mice. The study shows that supplementation with the amino acid significantly improves glucose metabolism in both insulin-sensitive and insulin-resistant metabolisms.In new experiments, researchers from the University of Copenhagen working in collaboration with a research group at the University of Cincinnati, have demonstrated that the amino acid arginine, found in salmon, eggs, and nuts, improves glucose metabolism significantly in both lean (insulin-sensitive) and obese (insulin-resistant) mice.

”In fact, the amino acid is just as effective as several well-established drugs for type 2 diabetics,” says postdoc Christoffer Clemmensen.  As improbable as it may seem, the most important molecule in regulating the function of our arteries is nitric oxide (NO), a gas better known to us as an air pollutant. As synthesized in our arteries in tiny quantities, however, NO acts as a powerful mediator of vasodilation, the mechanism by which arteries dilate, when necessary, to lower our blood pressure and increase the flow of blood to tissues that need it. The principal source of our NO is arginine. This occurs via enzyme-catalyzed reactions that occur in endothelial cells, the thin layer of smooth, tightly “tiled” cells that line the inner walls of our arteries. 

What researchers have found is that L-arginine potentiation of glucose-induced insulin secretion occurs independently of NO.

The researchers found that arginine improves glucose metabolism significantly in both lean (insulin-sensitive) and obese (insulin-resistant) mice. “We can also see that arginine increases the body’s production of glucagon-lik

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Aronia berry supplementation supports gut, arterial healthKing’s College London, October 17 2022.

The issue of Clinical Nutrition reported findings from a randomized, double-blind, placebo-controlled trial that uncovered a benefit for supplementation with aronia berry among men and women with prehypertension.

“Aronia melanocarpa, or black chokeberry, has gained increased attention for its high content of (poly)phenols, and potential protection against chronic diseases such as cardiovascular disease and diabetes,” authors Melanie Le Sayec of King’s College London and colleagues remarked.

The trial included 102 participants between the ages of 40 and 70 years who received aronia berry extract capsules that contained 106 milligrams total polyphenols or identical placebo capsules for 12 weeks. Blood pressure, arterial function, gut microbiome composition and other factors were assessed before and after the treatment period.

At the end of the study, augmentation index and pulse wave velocity, which measure arterial stiffness, significantly improved among participants who received aronia in comparison with the placebo group. The aronia-supplemented group also had a significant increase in microbiome species richness and abundance of species that produce butyrate, a compound that has a favorable effect in gut health.

The researchers observed associations between plasma and urinary aronia-derived polyphenol metabolites, decreased arterial stiffness and various gut flora species. “To our knowledge, this is the first time these species are shown to correlate with beneficial effects on arterial function,” they announced.

“The present findings suggest that daily consumption of aronia berry extract led to improvements in arterial function in healthy middle-aged people, with a concomitant and related increase in potentially health-promoting bacterial taxa,” the authors concluded.

Zinc enhances albumin’s protective role against Parkinson’s diseaseUniversity of Science and Technology, October 17, 2022

Revealing zinc’s interaction with a critical transport protein underscores the need to study biological pathways under physiologically relevant conditions.

Heavy metals in the body have long been thought to induce the aggregation of disease-linked proteins, but a KAUST study shows this is not always the case.

It turns out that zinc ions tune the ability of human serum albumin (HSA), an abundant transport protein in the body, to better prevent α-synuclein from aggregating, a process directly linked to Parkinson’s disease.

In unrealistically massive quantities, zinc tends to accelerate the aggregation of α-synuclein, a neuronal protein implicated in Parkinson’s disease. This is what other scientists had shown in the past. But, under the types of biologically plausible experimental conditions considered by Al-Harthi, the metal actually interacts with HSA to cause the opposite effect.

Using a state-of-the-art imaging technique known as proton-less nuclear magnetic resonance spectroscopy, Al-Harthi and colleagues showed that zinc binding alters the chaperone function of HSA, a multifunctional molecule that plays a role in blocking α-synuclein accretion. In particular, zinc ions biased HSA toward stronger interactions with the aggregation-prone fragments of α-synuclein, a change that blunts fibril formation and slows down the toxic process of protein deposition that can lead to neurodegeneration.

High exposure to glyphosate in pregnancy could cause lower birth weights in babiesIndiana University School of Medicine, October 17, 2022

Indiana Universit

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Research identifies the herbal supplements that are effective in treating anxiety

Global Neuroscience Initiative Foundation, October 6, 2022

A systematic review of research into the use of nutritional supplements for the treatment of anxiety disorders has found strong evidence for the use of extracts of passionflower or kava and combinations of L-lysine and L-arginine. Researchers writing in open access Nutrition Journal pooled the results of 24 studies involving a total of more than 2000 participants, showing that some nutritional and herbal supplements can be effective, without the risk of serious side effects.

The research was carried out by Shaheen Lakhan and Karen Vieira from the Global Neuroscience Initiative Foundation, a non-profit charity organization for the advancement of neurological and mental health patient welfare, education, and research, based in Los Angeles, USA. Lakhan said, “Our review and summary of the literature on herbal remedies and dietary supplements for anxiety should aid mental health practitioners in advising their patients and provide insight for future research in this field. We found mixed results – while passionflower or kava and L-lysine and L-arginine appeared to be effective, St John’s Wort and magnesium supplements were not”.

Of the studies included in the review, 21 were randomized controlled trials. Of these, 15 showed positive effects from either a nutritional or herbal remedy and any reported side effects were mild to moderate.

Melatonin improves mitochondrial function in rat model of diabetes

University of Granada, La Paz University Hospital & University of Texas,  October 6 2022. 

The Journal of Pineal Research published an article by researchers that reported a protective effect for melatonin on mitochondrial function in obese rats.

“Mitochondrial dysfunction in adipose tissue may contribute to obesity-related metabolic derangements such as type 2 diabetes mellitus,” write principle investigator Ahmad Agil and colleagues. “Because mitochondria are a target for melatonin action, the goal of this study was to investigate the effects of melatonin on mitochondrial function in white and beige inguinal adipose tissue of Zücker diabetic fatty rats.

The team divided eight diabetic rats and eight lean littermates to receive melatonin-enhanced or plain drinking water for six weeks, after which mitochondrial function was evaluated. They observed improvement in mitochondrial respiration, and a reduction in oxidative status among both lean and obese animals that received melatonin. 

He observed that, along with other factors, the rise in obesity in both developed and developing countries has coincided with exposure to artificial light at night, which inhibits the body’s production of melatonin.  The inhibition of melatonin production that occurs when a lamp, computer or television is left on leads to disrupted sleep and an increased risk of weight gain, which negatively impacts the mitochondria, promoting insulin resistance and diabetes. “For all these reasons, it is important to try to sleep in absolute darkness, to avoid interference in the generation of melatonin,” Professor Agil noted.

Walking can reduce breast cancer risk

American Cancer Society, October 4, 2022

Postmenopausal women who were very active or walked for at least seven hours a week had a reduced risk for breast cancer, according to a study published in Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research.

Women who engaged in at least an hour of vigorous physical activity every day had a 25 percent lower risk for breast cancer, and those who walked for at least seven hours a week had a 14 percent lower risk for bre

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Folic Acid Supplement Linked With Reduction in Suicide Attempts and Self-HarmUniversity Of Chicago, October 10, 2022

Study finds folic acid treatment is associated with decreased risk of suicide attempt. The common, inexpensive supplement was linked with a 44% reduction in suicide attempts and self-harm.With nearly 46,000 people in America dying by suicide in 2020, it is one of the leading causes of death in the US. To decrease the risk of suicide, experts recommend many strategies and treatments including psychotherapy, economic support, peer support, and medications such as antidepressants. Few if any would be likely to put folic acid supplements on that list. However, an eye-opening study recent conducted at the University of Chicago may change that.

The study, published on in JAMA Psychiatry, used data from the health insurance claims of 866,586 patients. It investigated the relationship between folic acid treatment and suicide attempts over a two-year period. They found that patients who filled prescriptions for folic acid, also known as vitamin B9, experienced a 44% reduction in suicidal events (suicide attempts and intentional self-harm). Robert Gibbons, PhD, the lead author of the study, is hopeful that these findings could improve suicide prevention efforts, especially because of how accessible folic acid is. He is the Blum-Riese Professor of Biostatistics and Medicine at the University of Chicago.

“There are no real side effects, it doesn’t cost a lot of money, you can get it without a prescription,” Gibbons said. “This could potentially save tens of thousands of lives.”

To investigate and further confirm the relationship between folic acid and suicide risk, Gibbons and his co-authors did this new study and focused specifically on folic acid, and accounted for many possible confounding factors, including age, sex, mental health diagnoses, other central nervous system drugs, conditions that affect folic acid metabolism, and more. Even after adjusting for all these factors, filling a prescription for folic acid was still associated with a decreased risk of attempting suicide.

They even found that the longer a person took folic acid, the lower their risk of suicide attempt tended to be. Each month of being prescribed folic acid was associated with an additional 5% decrease in risk of suicide attempt during the 24-month follow-up period of their study.

It also occurred to the authors that maybe people who take vitamin supplements, in general, want to improve their health and would thus be less likely to attempt suicide. To address this possibility, they did a similar analysis with another supplement, vitamin B12, as a negative control. But unlike folic acid, there didn’t seem to be any relationship between vitamin B12 and risk of suicide.

Zinc is cancer’s worst enemy: This mineral is key to preventing cancer, scientists concludeUniversity of Texas Arlington, October 3, 2022

Researchers from the University of Texas at Arlington have discovered the important role zinc can play in preventing cancer, especially the esophageal variety. Although past studies had indicated zinc had a protective effect on the esophagus when it comes to cancer, it wasn’t clear why.

A team of researchers led by Associate Professor of Nursing Zui Pan found that zinc has the incredibly useful ability to selectively stop the growth of cancerous cells while leaving normal esophageal epithelial cells intact. The researchers say their finding could help improve treatment for esophageal cancer and even provide some insight

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Omega-3 fatty acid stops known trigger of lupus

Michigan State University, September 29, 2022 

 

A team of Michigan State University researchers has found that consuming an omega-3 fatty acid called DHA, or docosahexaenoic acid, can stop a known trigger of lupus and potentially other autoimmune disorders.

 

"What we discovered was when lupus was triggered by crystalline silica, a toxic mineral also known as quartz that's linked to human autoimmunity, DHA blocked the activation of the disease," said Melissa Bates, one of the study's lead authors in MSU's Department of Food Science and Human Nutrition and the Institute of Integrative Toxicology.

 

The preclinical study looked at the effect of DHA on lupus lesions in the lungs and kidneys of female mice that were already genetically predisposed to the disease. Their results were overwhelmingly positive.

 

"Ninety-six percent of the lung lesions were stopped with DHA after being triggered by the silica," said Jack Harkema, another study author and pulmonary pathologist. "I've never seen such a dramatic protective response in the lung before."

 

Lupus is considered a genetic disease and is triggered not only by inhaling crystalline silica toxicants, but also by other environmental factors such as sun exposure. Quartz is the most common, and most dangerous, form of crystalline silica and is often found in the agriculture, construction and mining industries where workers can breathe in the mineral dust. Lupus is the body's immune system attacking itself and it can damage any part of the body including skin, joints and organs.

 

Although it's still unknown exactly why DHA is able to prevent the onset of lupus, the researchers said this study provides scientists with a better model for looking at just how much DHA is needed to ward off the environmental trigger of the disease.

 

According to Harkema, the DHA could be changing the way cells, also known as macrophages, react to the silica in the lungs and somehow alter the immune system's response.

 

"What we do know is this study is a clear indication that eating DHA can prevent this one type of environmental triggering of lupus," Pestka said. "It can suppress many of the disease's signaling pathways, which current drugs on the market now try to target and treat."

 

 

Study offers real-world evidence of vitamin D’s protective effectsGerman Cancer Research Center, October 12 2022. 

A study reported in the Journal of Internal Medicine provides “real-world” evidence of the benefits of vitamin D supplementation. 

“Given the increasing importance of real-world evidence in determining the drug effectiveness outside of the strictly defined and controlled situations of randomized controlled trials, it is of great interest how the efficacy data of vitamin D3 supplementation obtained from well-defined and well-controlled clinical trial populations translate into effectiveness in real-world practice,” the authors remarked. “The primary objective of this study was to investigate whether the intake of vitamin D supplements (in the form of a vitamin D preparation or as part of a multivitamin product) is associated with reduced all-cause and cause-specific mortality including cancer mortality, cardiovascular disease mortality and respiratory disease mortality in the large UK Biobank, a nationwide, population-based cohort from the United Kingdom.”

The researchers analyzed information from 445,601 UK Biobank participants. Regular vitamin D supplement use was reported by 4.3% of the participants and multivitamin use was reported by 20.4%. 

Vitamin D and multivitamin supplement users had higher median 25-hydroxyvitamin D levels

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Component of citrus fruits found to block the formation of kidney cysts

University of London and Kingston University, UK October 3, 2022

A study published in British Journal of Pharmacology has identified that a component of grapefruit and other citrus fruits, naringenin, successfully blocks the formation of kidney cysts.

Known as polycystic kidney disease, this is an inherited disorder which leads to the loss of kidney function, high blood pressure and the need for dialysis. Few treatment options are currently available.

The team of scientists from University of London and Kingston University London used a simple, single-celled amoeba to identify that naringenin regulates the PKD2 protein responsible for polycystic kidney disease and as a result, blocks formation of cysts.

To test how this discovery could apply in treatments, the team used a mammalian kidney cell-line, and triggered the formation of cysts in these cells. They were then able to block the formation of the cysts by adding naringenin and saw that when levels of the PKD2 protein were reduced in the kidney cells, so was the block in cyst formation, confirming that the effect was connected.

“Indeed, this study provides a good example of how chemicals identified in plants can help us develop new drugs for the treatment of disease,” added Professor Debbie Baines from St George’s, University of London.

Medical cannabis treats cancer and boosts the immune system, say scientists after reviewing more than 100 studiesRostock University Medical Center (Germany), October 1, 2022

A review of over 100 studies has shown that cannabis really is medicinal. Indeed, scientific analysis has shown that the cannabinoid compounds found in marijuana can stop cancer cells from dividing and spreading — and can even cut off blood supply to tumors. The researchers say that their findings prove that cannabis can be used as a cancer treatment. Does that mean plants will finally start getting recognized for their medicinal powers? One can only hope.

A team of German researchers, led by Professor Burkhard Hinz, have concluded that cannabis compounds can fight cancer. The scientists, say that an array of cannabinoids have medicinal value.

Professor Hinz and his team have shown that over 100 different studies have indicated cannabis has the ability to treat cancer.

“In this context accumulating data from preclinical models suggest that cannabinoids elicit anti-cancer effects on several levels of cancer progression,” Hinz explained.

“Clinical studies are now urgently needed to investigate the impact of cannabinoids on cancer growth and progression in patients,” he added.

Older adults living unhealthy lifestyles twice as likely to end up in a nursing homeOlder adults who lead an unhealthy lifestyle are twice as likely to end up needing a nursing home in comparison to their more active peers, a new study reveals.

Researchers at the University of Sydney found smoking, physical activity, sitting, and sleep quality to have a strong link to nursing home admission rates. Surprisingly, diet quality did not display the same connection.

Smokers were 55 percent more likely than non-smokers to end up needing nursing care. For the study, which is the first of its kind, researchers looked at data on more than 127,000 Australians who took part in a large study on healthy aging between 2006 and 2009. Study authors followed up with these patients for 11 years on average.

The team divided them into the three risk groups based on five lifestyle factors: smoking, physical activity, sitting, sleep quality, and diet quality.

One quarter of participants (24%) ended up in the lowest ri

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Resveratrol supplementation linked to better blood lipidsSoutheast University (China), October 10 2022.

A meta-analysis of randomized, controlled trials published in the journal Nutrients found an association between lower lipids and supplementing with resveratrol, a nonflavonoid polyphenol compound found in grapes, knotweed and other plants.

Researchers at Southeast University in Nanjing, China identified 17 trials that included a total of 968 men and women for their meta-analysis. Resveratrol doses ranged from 10 to 3,000 milligrams per day administered from 4 to 48 weeks.

The meta-analysis revealed a significant association between resveratrol supplementation and reductions in total cholesterol, low-density lipoprotein (LDL) cholesterol and triglyceride levels. The reduction in LDL cholesterol associated with resveratrol was significantly greater in trials of at least 12 weeks duration, trials that administered dosages of 500 milligrams resveratrol per day or more and among people with type 2 diabetes. The researchers did not find an association between supplementing with resveratrol and “good” high-density lipoprotein (HDL) cholesterol levels.

“This meta-analysis indicated that the supplementation of resveratrol could significantly affect the serum levels of total cholesterol, LDL-cholesterol and triglycerides, but not the level of HDL-cholesterol,” they concluded. “Findings from this meta-analysis could be helpful for providing suggestions for the use of resveratrol as nutraceutical.”

A Mulberry Component, Prevents SARS-CoV-2 Infection by Blocking the Interaction between SARS-CoV-2 Spike Protein S1 Receptor-Binding DomainKorea Institute of Oriental Medicine, September 28, 2022

Despite the recent development of RNA replication-targeted COVID-19 drugs by global pharmaceutical companies, their prescription in clinical practice is limited by certain factors, including drug interaction, reproductive toxicity, and drug resistance. Natural products are a potential source of molecules with therapeutic effects against COVID-19.

In this study, we investigated the inhibitory efficacy of mulberrofuran G (MG), a component of mulberry, which has been used as food and traditional medicine, on the binding of the spike S1 receptor-binding domain (RBD) protein to the angiotensin-converting enzyme 2 (ACE2) receptor, which is the initial stage of the SARS-CoV-2 infection. In competitive enzyme-linked immunosorbent assays, MG effectively blocked the spike S1 RBD: ACE2 receptor molecular binding, and investigations using the BLItz system and in silico modeling revealed that MG has high affinity for both proteins.

Finally, we confirmed that MG inhibits the entry of SARS-CoV-2 spike pseudotyped virus and a clinical isolate of SARS-CoV-2 into cells, suggesting that MG might be a promising therapeutic candidate for preventing SARS-CoV-2 binding to the cell surface during early infection.

Positive childhood experiences of blue spaces linked to better adult well-beingSapienza University (Italy) & University of Exeter (UK), October 10, 2022New research based on data from 18 countries concludes that adults with better mental health are more likely to report having spent time playing in and around coastal and inland waters, such as rivers and lakes (also known collectively as blue spaces) as children. The finding was replicated in each of the countries studied.

Mounting evidence shows that spending time in and around green spaces such as parks and woodlands in adulthood is associated with stress reduction and better mental health. However, we know far less ab

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Quinoa-Based Diet Stabilizes Blood Sugar In Older AdultsUniversity of Barcelona (Spain), October 2, 2022

According to a recent study published in the journal Nutrients, a quinoa-based diet was able to normalize glucose metabolism, and this effect was more pronounced among elderly people with impaired glucose tolerance, suggesting that quinoa is a healthy pseudocereal that is far more beneficial and nutritious than other cereal products.

This study examined the effects of a quinoa-rich diet on mediating hyperglycemia and other metabolic risk factors. Glycemic data was collected by glucose sensors operating over extended periods of time with regular prespecified recording points that could be analyzed using the functional data analysis approach to yield glucose concentrations over time.

All of the participants in this pilot study were aged 65+, without a history of diabetes, and fasting glucose levels were between 100-125 mg/dL. The participants ate grains, legumes, and tuber daily while also consuming quinoa, quinoa flakes, and quinoa flour as well as biscuits, brioche, sponge cake, baguettes, sliced bread, and pasta which all had a quinoa content of 70% or greater.

During the initial four weeks, the participants consumed their regular diets, then they were switched to the quinoa-based diet for the following four weeks, during this time all grains, grain-based products, legumes, and tubers were substituted with quinoa-based products without changing the overall composition of nutrients with exception to the cereal. During the study, all food products were provided to the participants who commonly consumed them. Additionally, eight recipes were introduced to the participants using quinoa substitutions.

At the beginning of the study most of the participants had an overweight profile, and hypertension, 45% had high blood lipids, and 33% had one or more close family members with disease. At the end of the study glucose levels were reduced before and after the quinoa-based diet, and glycated hemoglobin levels were reduced by the end of the study, as was weight and waist circumference by slight decreases.

Additional analysis revealed that multiple nutrients were associated with enhanced or reduced glucose concentrations: Gamma-tocopherol, soluble fiber insoluble dietary fiber, and ORAC were associated with enhanced glucose concentrations, while fatty acids, fructose, citric acid, cellulose, phytic acid, omega-6 PUFA, theobromine, and the proportion of total energy from proteins had a link with reduced glucose concentrations.

The nutritional profile of quinoa accounts for the difference in nutritional intake between the two diet phases. Consuming more carbs increases insulin levels, and fat storage and reduces the metabolic rate causing a cycle of fat accumulation. A high-fat diet with the same amount of calories reduces insulin secretion by triggering fat turnover in the cells making free fatty acids available for use in energy production. Dietary proteins also enhance the building of lean muscle during weight loss which also helps to expend more energy and improve the overall body composition.

Mediterranean diet improves immunotherapy response rates and progression-free survival in advanced melanoma, new study suggestsEating a Mediterranean diet, rich in fibre, mono-unsaturated fatty acids and polyphenols, has been associated with improved immunotherapy response rates and progression-free survival in advanced melanoma patients.

University Medical Center Groningen (Netherlands), October 9, 2022

Eating a Mediterranean diet, rich in fibre, mono-unsaturated fatty acids and polyphenols, has been associate

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Rhodiola found to be an effective herbal medicine for treating fatigue and weaknessNational Academy of Medical Sciences of Ukraine, September 28, 2022

With everything that’s going on in life, it’s normal to feel tired at some point. Fatigue is a condition characterized by extreme feelings of either physical or mental tiredness. One study shows that rhodiola (Rhodiola rosea) can be used as an herbal medicine for fatigue.

People who are experiencing fatigue can have symptoms like sore muscles, lack of motivation, headaches, drowsiness, and irritability. If fatigue lasts for one to six months it can be classified as prolonged fatigue. However, if it goes beyond that it is already classified as chronic fatigue. Studies show that a third of the adult population has experienced chronic fatigue at least once in their life. With the high prevalence of chronic fatigue, it is unfortunate that there is still no standard medication available for it.

Previous studies have shown that rhodiola can reduce symptoms in people suffering from mental fatigue. In addition to this, animal studies have also revealed that rhodiola can stimulate physical work capacity.

For this study, which was published in Complementary Medicine Research, the researchers looked at rhodiola as a potential medication for prolonged and chronic fatigue. Researchers performed a clinical trial with 100 participants suffering from either prolonged or chronic fatigue. Although the trial lasted for eight weeks, significant improvements in fatigue symptoms were already observable after just one week. Further improvements could still be observed throughout the trial period. Furthermore, no adverse effects were observed with rhodiola intake.

Parenting practices in teen years set the stage for closeness, warmth later onPenn State University, October 5, 2022High-quality parenting practices in adolescence lay the foundation for close parent-child relationships when the children become young adults, according to new research from Penn State.

The study is one of the first to examine how changes in parental involvement, parental warmth, and effective discipline during adolescence predict the quality of the relationships between parents and their young adult children, said Greg Fosco, professor of human development and family studies and associate director of the Edna Bennett Pierce Prevention Research Center at Penn State, who was co-principal investigator on the study.

The study’s findings were published recently in Developmental Psychology. The research team surveyed 1,631 participants in a long-term research study of families in rural and semi-rural Pennsylvania and Iowa who completed surveys between sixth and 12th grades and again at age 22.

“Our research showed that parenting can change a lot during the teenage years: parents often express less warmth and affection, spend less time with their teens, and become more harsh in their discipline. Parents that were able to maintain positive parenting and involvement laid the foundation for a close relationship when their teens became adults,” said Fosco.

Staying involved in teens’ lives may look different than when they were younger, and it can be challenging to stay close with teens as they seek greater independence and autonomy, Fosco acknowledged. Based on the study’s findings, he suggested these activities:

Do something together, like playing sports, bike riding, exercising, going for a walk, gaming, cooking, attending events, or going out for a meal or dessert.Work on a project togethe