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The Health Edge: translating the science of self-care
The Health Edge: translating the science of self-care episodes
- Understanding the Complex World of Proteins, Essential Amino Acids, and the Role of IGF-1 in Brain Health
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Are you ready to unlock the mysteries of protein and its pivotal role in our dietary intake? Strap in as we guide you through the complex world of essential amino acids, and the significant part they play in our bodies. We discuss the importance of achieving a balance in your protein consumption, focusing on the dietary reference intakes, and the potential risks of under-consuming protein. Discover why 25 grams of protein per meal can be beneficial for you, and the distinctions between plant and animal-based protein sources.
Unravel the potential of different essential amino acids and the exceptional benefits of branch chain amino acids found in dairy and egg products. Did you know they are crucial for muscle sparing? We explore this and more, including the importance of sulfur-containing amino acids, typically found in animal proteins, for detoxification and various physiological processes. Discover the vital collateral nutrients, like B12, Vitamin D, DHA, heme-iron, and zinc, found in animal food sources that are easily absorbed and more bioavailable in our systems.
Dive deeper into the world of IGF-1 and its significant role in brain health. We examine its importance for neurogenesis, cognitive preservation, anti-oxidant, and anti-inflammatory processes. Learn about the potential risks and benefits of controlling IGF-1 levels, including an increased risk of breast and prostate cancer, and its balancing act with insulin resistance. We also delve into the unique role branched chain amino acids play in stem cell development and brain health. Lastly, find out how strength training and exercise can influence IGF-1 binding proteins, and why this could be a game-changer for managing IGF-1. Join us in this enlightening conversation as we enhance your understanding of protein intake and sources.44 min - Powerful Lifestyle Medicine Interventions
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In this podcast Mark reviews the current paradigm linking environmental inputs-lifestyle with epigenetics and the human microbiome. He translates these connections ibto effective lifestyle medicine interventions. The PowerPoint below goes with the audio recording. You Tube recording can be found below. PowerPoint slides can be downloaded at www.thehealthedgepodcast.com
Enjoy!1 hr 8 min - Research Getting Our Attention
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In this episode of the Health Edge Mark and John discuss areas of research they are closely following. John shares some interesting fatty acid research and introduces heptadecanoic acid as an emerging 17-carbon fat, important to healthy brain aging. Mark reviews some aging and longevity research he is following. Topics include epigenetic aging, biologic age regression using Yamanaka factors, gene and cell therapies, and senolytics.
30 min - LDL blood levels and mortality risk
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In this episode of The Health Edge Mark and John review some papers that challenge the well accepted clinical meme that lowering LDL should be the focal point of reducing CV risk and all-cause mortality risk.
Papers referenced:
https://www.nature.com/articles/s4159...
https://bmjopen.bmj.com/content/6/6/e...
https://www.ncbi.nlm.nih.gov/pmc/arti...43 min - Does excessive sodium restriction lead to insulin resistance?
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In this episode of The Health Edge Mark and John review a recent paper drawing connections between excessive sodium restriction and insulin resistance. This adds to a growing body of research suggesting the restriction of sodium below 3-4 gms/day may in fact add to cardiometabolic risk. Current guidelines of 2300 mg/day or less fall well below these levels.
36 min - Sodium Restriction in Hypertension: Is too low dangerous?
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This is a replay of a prior podcast examining the relationship between sodium and hypertension. A growing body of research suggests there is a point below which e.g. 3,000 mg/day where risk is increased. This recording is a prelude to our upcoming podcast on sodium restriction and insulin resistance.
54 min - Erythritol and Cardiovascular Risk: Is there a real concern here?
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In this Health Edge podcast recording, Mark and John review a recent paper that drew a strong relationship between erythritol levels in the blood with major adverse cardiovascular (MACE) events. Mark and John anayize the study and offer perspective.
https://www.nature.com/articles/s41591-023-02223-9
Another recent review of risks and benefits of erythritol.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9824470/26 min - Chronic Kidney Disease (CKD): An under recognized cardiovascular complication
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In this Health Edge recording Mark and John review recent data on the prevalence of CKD in the US. They review common drivers of CKD and offer many lifestyle medicine recommendations for prevention and management.
50 min - Time Under the Load:The critical relationship between muscle mass, cognition and all-cause mortality
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In this episode of the Health Edge, mark and John review two important studies. The first is a systematic review/meta analysis that clearly links loss of lean body mass (sarcopenia) with all-cause mortality and cardiovascular disease risk. The second paper reviews the underlying mechanisms that link lower muscle mass with greater risk of cognitive decline with aging.
https://bjsm.bmj.com/content/56/13/755.info
https://pubmed.ncbi.nlm.nih.gov/35661882/38 min - Alzheimer's and Mild Cognitive Impairment (MCI): Is this epidemic a one-way street?
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Few age-related diseases are more devastating than Alzheimer's. A recent study from Columbia University suggests in individuals 65+ years of age, 10% have a dementia diagnosis and almost 25% have a diagnosis of MCI or mild cognitive decline. For the 90+ age demographic, over 30% have a dementia diagnosis. The costs to the individuals and those who care for them is staggering. In this recording, mark and John review the data from this paper (Annals of Neurology October 2022) and offer a different perspective on how to prevent, what today, feels like a one-way street.
45 min
About The Health Edge: translating the science of self-care
From the publisher's feed
“It’s not what we don’t know that gets us into trouble. It’s what we know that ain’t so”.
Will Rogers
We believe the explosion of life science research from many…
disciplines had catapulted ahead of our capacity to process, integrate, understand, and apply. We are interested in translating all that is out there as news to use. A fundamentally different understanding of human biology has emerged. The implications from the perspective of self-care are profound. We are rapidly moving away from the debate of nature versus nurture toward an understanding that life emerges from a dynamic landscape of nature via nurture.
We are passionate about the science. We are passionate about the implications. We believe in the capacity and possibility made possible by being alive here and now! We are beautifully designed to be on the African Savannah, living fully integrated with our planet, and in the context of social relationship. Our modern environment is not well designed to promote human health and the capacity to thrive. Many are struggling to maintain balance and traction in lives that often feel overwhelming and frightening.The challenge is to better leverage our superb ancestral adaptation for a different and radically challenging modern environment. Everything that touches us today has the potential be be very familiar or totally foreign. The less aware one is of the day to day distance between what we are biologically , as a species, “familiar with” and what we actually encounter, the fewer the possibilities for more effective alignment.
Leaving one’s health trajectory to chance in our modern environment is a very risky proposition. We are interested in holding the science to the light with an open and humbled mindset. Like you, We are intrepid explorers interested in how we emerge in the midst of our relationship with the environmental inputs of our lives…how we eat, how we move, how we sleep, how we navigate the mind fields of conflict in our lives, how socially connected we are, how we manage the burden of environmental toxins in our lives, how much meaning we cultivate in our work, love, play and how we interpret and respond to stress in our lives. We will drill deep, share all that my experiences has taught and do all that we can to create value for you as you seek to find your health edge. We always welcome your feedback.
Mark and John
We are passionate about the science. We are passionate about the implications. We believe in the capacity and possibility made possible by being alive here and now! We are beautifully designed to be on the African Savannah, living fully integrated with our planet, and in the context of social relationship. Our modern environment is not well designed to promote human health and the capacity to thrive. Many are struggling to maintain balance and traction in lives that often feel overwhelming and frightening.The challenge is to better leverage our superb ancestral adaptation for a different and radically challenging modern environment. Everything that touches us today has the potential be be very familiar or totally foreign. The less aware one is of the day to day distance between what we are biologically , as a species, “familiar with” and what we actually encounter, the fewer the possibilities for more effective alignment.
Leaving one’s health trajectory to chance in our modern environment is a very risky proposition. We are interested in holding the science to the light with an open and humbled mindset. Like you, We are intrepid explorers interested in how we emerge in the midst of our relationship with the environmental inputs of our lives…how we eat, how we move, how we sleep, how we navigate the mind fields of conflict in our lives, how socially connected we are, how we manage the burden of environmental toxins in our lives, how much meaning we cultivate in our work, love, play and how we interpret and respond to stress in our lives. We will drill deep, share all that my experiences has taught and do all that we can to create value for you as you seek to find your health edge. We always welcome your feedback.
Mark and John
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