Beta-glucans might be one of the most overlooked levers in immune resilience, and that has major implications for longevity. Talking with my long-time friends and colleagues Drs. Bob Rountree and Chris D’Adamo reminded me just how powerful this molecule truly is. The clinical reach here is stunning, from immune aging and cancer support to vaccine response, gut–brain effects, and overall resilience.

What struck me most is how beta-glucans help the innate immune system respond more effectively over time, from overtraining and chronic infections to vaccine responsiveness. Clinicians really need this on their radar. I think you’re going to find this conversation eye-opening. ~DrKF

Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast/ for the full list of links and resources.

GUEST DETAILS

Bob Rountree, MD, is a leading figure in integrative and functional medicine with more than 40 years of clinical experience. Medical Director of Boulder Wellcare and long-time IFM faculty, he is widely published and a respected educator in personalized medicine, botanical therapies, and immune health.

Chris D’Adamo, PhD, is a research scientist and epidemiologist focused on how nutrition, lifestyle, and environmental factors influence health. An Assistant Professor at the University of Maryland School of Medicine, he has led numerous clinical studies, published widely, and is a trusted advisor and educator in integrative and lifestyle medicine.

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In this episode of New Frontiers in Functional Medicine, Dr. Kara Fitzgerald sits down with hormone and women’s health expert Dr. Carrie Jones to explore the powerful connection between mitochondrial health and women’s hormones. Together, they unpack how mitochondrial function influences hormone balance, metabolism, energy, mood, and resilience, especially during perimenopause and menopause. Dr. Jones shares practical, evidence-based strategies to support mitochondrial health for optimal hormonal balance, improved sleep, and emotional well-being.

Listeners will gain actionable insights into functional medicine approaches to women’s hormone health, including how mitochondrial vitality can help ease hormonal transitions and enhance longevity.

Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast/ for the full list of links and resources.

GUEST DETAILS

Dr. Carrie Jones, ND, FABNE, MPH, MSCP is an internationally recognized expert in women’s health and hormones. Known as the “Queen of Hormones,” she’s a naturopathic physician, educator, and Chief Medical Officer at NuEthix Formulations. With over 20 years in the field, Dr. Jones has shaped hormone education through her work with major functional labs and her hit podcast, Hello Hormones.

Email: [email protected]

Website: https://www.drcarriejones.com/

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Dr. Kara Fitzgerald sits down with Dr. Brooke Stubbs, an internal and lifestyle medicine physician who transitioned from hospital medicine to a concierge model focused on prevention and personalization. Together, they discuss how to design a practice that supports both patients and practitioners, from efficient systems and appropriate pricing to functional lab integration.

Dr. Stubbs explains how Vibrant Wellness helps streamline diagnostics and ensure consistent, high-quality care, offering real-world insights for clinicians ready to evolve their model.

Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast/ for the full list of links and resources.

GUEST DETAILS

Dr. Brooke Stubbs is a double board-certified physician in Internal and Lifestyle Medicine with a master’s in nutrition from Columbia University. As founder of Rooted Femme, a concierge practice in Austin, she helps women achieve better health through lifestyle-based care. She’s a national speaker, retreat creator, and advocate for integrating science, art, and compassion into modern medicine.

Website: https://www.rootedfemme.com/

LinkedIn Profile: https://www.linkedin.com/in/brookestubbsmd/

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SPONSOR: Vibrant Wellness

http://vibrant-wellness.com/drfitzgerald

Vibrant Wellness’ innovative testing panels identify key imbalances in areas like nutrition, hormones, toxins, and the gut microbiome—so you can take targeted steps toward optimal wellness. Discover the possibilities and become a provider or connect with one near you at http://vibrant-wellness.com/drfitzgerald

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Dr. Kara Fitzgerald talks with Sergey Young, founder of the Longevity Vision Fund and XPRIZE board member, about the future of aging medicine. Hear how AI, wearables, new diagnostics, and early screening are making longevity solutions more practical, affordable, and clinically relevant for functional medicine practitioners.

Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast/ for the full list of links and resources.

GUEST DETAILS

Sergey Young is a longevity investor, author, and visionary committed to extending healthy lifespans for one billion people. He co-founded the BOLD Longevity Growth Fund, wrote the bestseller The Science and Technology of Growing Young, and serves on the boards of XPRIZE and AFAR.

Website: https://sergeyyoung.com/

Follow Sergey: @sergeyyoung200

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Hair loss is more than cosmetic. In this episode of New Frontiers in Functional Medicine, Dr. Kara Fitzgerald explores new research on the OS-01 peptide and its role in targeting senescent cells. Learn how peptide therapy compares to minoxidil, and how hormones, thyroid health, stress, UV exposure, and the scalp microbiome all play a role in thinning hair. Carolina Reis Oliveira, PhD, co-founder of OneSkin, shares insights on how polyphenols, prebiotics, and integrative strategies can support healthier growth.

Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast/ for the full list of links and resources.

GUEST DETAILS

Carolina Reis Oliveira, PhD - OneSkin Co-Founder & CEO

Carolina Reis Oliveira, PhD, is the CEO and co-founder of OneSkin and an advocate for healthy aging. With a doctorate in immunology, she moved from Brazil to Silicon Valley to pursue her vision of using science to prevent age-related diseases. At OneSkin, she leads pioneering research on aging biology, including the development of the proprietary OS-01 peptide, the first scientifically proven to reverse skin’s biological age.

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Interested in reclaiming your roots and addressing hair thinning? Visit https://oneskin.co/DRKARA for 15% off your purchase of OneSkin’s OS-01 HAIR peptide scalp serum.

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Want more? Join our newsletter here: https://www.drkarafitzgerald.com/newsletter/ Or take our pop quiz and test your BioAge! https://www.drkarafitzgerald.com/bioagequiz

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Have you ever struggled to understand why some patients just don’t respond as expected, even when you’re following all the usual gut protocols? In this episode, I sat down with Dr. Tom Fabian, who breaks down the latest insights from StoolOMX and GI-MAP testing and shows us how to put them into practice for our most complex cases.

We dive into how identifying specific types of inflammation, bile acid patterns, and microbial imbalances can guide more precise interventions, whether it’s introducing fiber, addressing biofilms, or supporting secondary bile acid production. Dr. Fabian makes the science practical, helping us see not just what’s happening in the gut, but what to do about it in real-world clinical settings. ~DrKF

FOLLOW ALONG WITH THE CONVERSATION!

Curious about the StoolOMX Add-On to GI-MAP? Head to http://tinyurl.com/StoolOMX to download the StoolOMX Reference Guide to better understand results and create effective, actionable protocols

Listeners, join me and Dr. Tom Fabian for a free webinar on October 23rd 2025 and get your questions answered on all things on all things bile acids, pattern recognition on functional stool testing and precision-based interventions for optimal gut health and longevity. Register here: ​​https://tinyurl.com/ydzsh6y6

Check out the show notes at www.drkarafitzgerald.com/fxmed-podcast/ for all the relevant links and resources.

GUEST DETAILS

Thomas Fabian, PhD, CNTP

Email: [email protected]

Dr. Tom Fabian, PhD, is a translational scientist focused on applying microbiome research in functional and integrative medicine. He serves as a consultant and science advisor with Diagnostic Solutions Laboratory, sits on the Science Advisory Board at Designs for Health, and is a certified Nutrition Therapy Practitioner.

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Can functional medicine unlock the secrets to healthy aging? In this special preview of the Functional Medicine is Longevity Medicine™ Masterclass happening on September 17- September 19, 2025, Dr. Kara Fitzgerald sits down with three leading voices in medicine and research:

- Dr. Bob Rountree: functional medicine pioneer in integrative approaches to health

- Dr. Dale Bredesen: internationally recognized expert on Alzheimer’s prevention and reversal

- Dr. Charles Serhan: Harvard researcher on inflammation resolution and aging biology

Together, they explore how functional medicine reframes longevity by addressing root causes, supporting cognitive health, and resolving chronic inflammation.

Whether you’re a clinician, health professional, or simply passionate about living longer and healthier, this conversation offers a glimpse into the science and practical applications that are transforming longevity medicine.

WATCH NOW TO LEARN:

- Why functional medicine is central to extending healthspan

- The latest insights on Alzheimer’s prevention and brain health

- How inflammation resolution impacts aging and chronic disease

- What to expect in the full Functional Medicine is Longevity Medicine™ Masterclass

Learn more & register for the Masterclass here: www.functionalmedicineislongevitymedicine.com

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It was a pleasure to sit down with Dr. Nir Barzilai for a conversation that turned out to be both lively and thought-provoking. His decades of research on centenarians, biological age, and the hallmarks of aging have shaped how we think about longevity—and what’s possible when we start targeting aging itself, not just individual diseases.

We get into the science behind why some people live 20–30 years longer and healthier, and what it means to measure the biological age of individual organs. But we also hit a few sparks—especially when it comes to nutraceuticals and the role of metformin in prevention. I don’t agree with everything you’ll hear, and I followed up with Dr. Barzilai afterward to unpack some of the more provocative claims. We may just need a second round for this one... stay tuned.

Check out the show notes at www.drkarafitzgerald.com/fxmed-podcast/ for all the relevant links and resources. ~DrKF

Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast/ for the full list of links and resources.

GUEST DETAILS

Nir Barzilai M.D.

Director of the Einstein Institute for Aging Research

Professor of Medicine and Genetics

President of the Academy for Health & Lifespan Research

Website: https://einsteinmed.edu/faculty/484/nir-barzilai

Email: [email protected]

Dr. Nir Barzilai is a pioneer in aging science, known for his work on centenarians, the biology of aging, and the TAME trial. He is Director of the Institute for Aging Research at Albert Einstein College of Medicine and author of Age Later and has published over 330 papers.

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Want more? Join our newsletter here: https://www.drkarafitzgerald.com/newsletter/ Or take our pop quiz and test your BioAge! https://www.drkarafitzgerald.com/bioagequiz

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I’ve been watching the science behind Calocurb evolve over the last year, and I have to say—this is one of the most exciting clinical tools I’ve seen emerge in the metabolic space in quite some time. A hops-derived compound that stimulates endogenous GLP-1, CCK, and PYY—without a prescription or injection? That’s a big deal, especially for patients struggling with appetite regulation, weight plateaus, or the aftermath of GLP-1 discontinuation.

In this episode, I sit down with Sarah Kennedy, founder of New Zealand-based Calocurb, to talk about the years of government-funded research that led to this discovery, the remarkable clinical outcomes they’ve seen so far, and how I’ve personally used it in my practice with excellent results. If you’re looking for science-backed, natural strategies to support appetite control, fasting, or GLP-1 transitions—this one’s worth a listen. ~DrKF

Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast/ for the full list of links and resources.

GUEST DETAILS

Sarah Kennedy, Founder and CEO of Calocurb Ltd.

Email: [email protected]

LinkedIn: https://www.linkedin.com/in/sarah-kennedy-0a840b13/

Sarah Kennedy, BVSc, is a veterinarian and health industry leader with 20+ years in nutrition science and innovation. Now CEO of Calocurb, she brings a unique perspective on natural GLP-1 activation—bridging plant-based research, gut physiology, and clinical application.

THANKS TO OUR SPONSOR: Calocurb

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Manage cravings and feel full faster with Calocurb, a 100% natural capsule that supports healthy weight management. Visit http://calocurb.com/drkara10 and use code DRKARA10 at checkout.

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Join Dr. Kara Fitzgerald and leading experts *LIVE on Sept 17–19, 2025* for a free virtual Masterclass on redefining healthcare & longevity through the lens of science-backed, systems-based approach. Register now: https://www.functionalmedicineislongevitymedicine.com/

Want more? Join our newsletter here: https://www.drkarafitzgerald.com/newsletter/ Or take our pop quiz and test your BioAge! https://www.drkarafitzgerald.com/bioagequiz

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In this very special episode, I have the privilege of turning the tables on Dr. Kara Fitzgerald as we celebrate 10 years of the New Frontiers podcast. I’ve been honored to walk alongside Kara on much of this journey—as a colleague, a collaborator, a mentee, and a friend—and it’s been incredible to witness the evolution of both her work and the field itself.

Together, we reflect on the stories, science, and people who have shaped this podcast—and the remarkable growth of epigenetics, personalized medicine, and functional medicine along the way. From early conversations around methylation and aging to hosting pioneers like Dr. Jeff Bland, Dr. Sidney Baker, and Dr. Charles Serhan, New Frontiers has become a living archive of how this field has moved forward.

As we talked about during the conversation: “Everybody is a piece of this ecosystem, and everybody has their role... It’s really cool to be part of that community.” This episode is a celebration of that collective journey—and a look at where we’re headed next. ~Romilly Hodges MS CNS

Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast/ for the full list of links and resources.

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CONNECT with DrKF

Want more? Join our newsletter here: https://www.drkarafitzgerald.com/newsletter/ Or take our pop quiz and test your BioAge! https://www.drkarafitzgerald.com/bioagequiz

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