GLP-1 receptor agonists have transformed weight loss and metabolic health—but what are we overlooking? In this episode of New Frontiers in Functional Medicine, Dr. Kara Fitzgerald is joined by Dr. Sanjay Bhojraj and Dr. Alexis Gonzales to explore the clinical tradeoffs of GLP-1 therapy, including lean muscle preservation, nutrient status, weight regain, and long-term metabolic health.

The conversation also examines SiPore, an engineered silica-based intervention that works locally in the GI tract to slow the breakdown and absorption of carbohydrates and fats. Dr. Fitzgerald and her guests discuss findings from the randomized, double-blind, placebo-controlled SHINE trial, including outcomes related to A1c, visceral fat, waist circumference, cholesterol, and lean mass.

They also explore how CGMs can reveal post-meal glucose patterns, why muscle preservation matters during weight loss, and how clinicians can support patients transitioning off GLP-1 medications—including those preparing for pregnancy, IVF, or surgery.

Full show notes + references: https://www.drkarafitzgerald.com/fxmed-podcast/

GUEST DETAILS

Sanjay Bhojraj, MD, FACC is an interventional cardiologist and Fellow of the American Academy of Anti-Aging Medicine specializing in cardiometabolic health, longevity medicine, and precision cardiovascular prevention.

He’s the founder of the Laguna Institute of Functional Medicine. His programs focus on reversing metabolic dysfunction, improving resilience, and reducing cardiovascular risk through lifestyle optimization and advanced diagnostic testing.

Dr. Alexis Gonzales ("Dr. G") is OvationLab’s Senior Clinical Implementation and AI Specialist, translating breakthrough research into practical clinical workflows, and holds advanced degrees in biochemistry (Saint Mary’s), biotechnology (Johns Hopkins), and naturopathic medicine (Bastyr).

She provides concierge functional-medicine care at her private practice in California—focusing on endometriosis, fertility, PCOS, and menopause—while distilling emerging research into practical frameworks at conferences to make integrative solutions accessible.

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Longevity medicine is expanding beyond biological age, biomarkers, and emerging technology. In this special episode of New Frontiers in Functional Medicine, Dr. Kara Fitzgerald shares four thought-provoking conversations exploring the science, clinical tools, and deeply human questions shaping the future of healthspan.

Dr. Dale Bredesen and Dr. Kat Toups discuss preliminary findings from their six-site randomized controlled trial evaluating a personalized precision medicine approach to cognitive decline, including changes in cognitive performance, neuroplasticity, and Alzheimer’s-related biomarkers.

Peter Diamandis explores AI, exponential technologies, and the future of medicine—while considering whether technological advances could ever replace the foundational role of diet, movement, sleep, and lifestyle.

Dr. Aviva Romm examines the evolving understanding of PCOS, reproductive health as a vital sign, and the metabolic, hormonal, inflammatory, environmental, and psychosocial factors influencing women’s health across the lifespan.

Stanford-trained physician and public health advocate Dr. Casey Means joins Dr. Fitzgerald for a thought-provoking reflection on what it means to be human. She also speaks on pregnancy, birth, public scrutiny, health beyond biomarkers, and the roles of equanimity, stewardship, connection, and meaning in a well-lived life.

Join Dr. Kara Fitzgerald and more than 30 leading clinicians, researchers, and educators for the free Functional Medicine IS Longevity Medicine Masterclass, live September 18–19, 2026. Register here: https://functionalmedicineislongevitymedicine.com

If this episode expands how you think about longevity or patient care, share it with a colleague and join the conversation in the comments.

Full show notes + references: https://www.drkarafitzgerald.com/fxmed-podcast/

Website: https://www.drkarafitzgerald.com/virtual-masterclass-for-clinicians/

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In this episode of New Frontiers in Functional Medicine, Dr. Kara Fitzgerald is joined by Dr. Emily Stone Rydbom, Dr. Leslie Stone, and Dr. Kalea Wattles to explore the science of preconception health, fertility, epigenetics, and chronic disease prevention.

Learn how maternal nutrition, mitochondrial health, methylation, the microbiome, inflammation, and environmental exposures influence fertility, pregnancy outcomes, and lifelong health through the Developmental Origins of Health and Disease (DOHaD) framework.

Topics include:

• Why chronic disease risk may begin before conception

• Epigenetics, methylation, folate, and MTHFR

• Mitochondrial health and fertility

• Functional medicine approaches to infertility and pregnancy

• The future of AI and precision medicine in reproductive healthcare

Whether you're a healthcare practitioner, planning a pregnancy, or simply interested in functional medicine and precision health, this episode offers practical, science-backed insights into improving health across generations.

Full show notes + references: https://www.drkarafitzgerald.com/fxmed-podcast/

GUEST DETAILS

Emily Stone Rydbom, MDH, BCHN, CNP is a Board Certified Holistic Nutritionist specializing in functional and precision nutrition for maternal, pediatric, and chronic disease care. She is co-founder of GrowBaby, an integrated OB–nutrition care model, and partners with healthcare systems to deliver genomics- and biomarker-informed maternal health programs.

Leslie Stone, MD is a Board Certified Family Practice Obstetrician with fellowship training in Surgical Obstetrics. A co-founder of GrowBaby and principal investigator of the ROOT Study, she has spent more than a decade integrating functional medicine into evidence-based obstetric care, delivering over 5,000 babies throughout her career.

Kalea Wattles, ND, IFMCP is a naturopathic physician, certified functional medicine practitioner, and founder of Functional Fertility. She specializes in unexplained infertility, preconception optimization, and fertility over 35, translating the latest reproductive medicine research into practical, personalized care.

Website:

www.growbabyhealth.com / www.growhealth.co / www.growbabylifeproject.org

https://www.drkaleawattles.com

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Can skincare influence healthy aging beyond reducing fine lines and wrinkles?

In this episode of New Frontiers in Functional Medicine, Dr. Kara Fitzgerald welcomes Carolina Reis Oliveira, PhD, CEO and co-founder of OneSkin, for a science-based discussion on cellular senescence, skin aging, and the connection between skin health and longevity.

Carolina explains the research behind OneSkin's OS-01 peptide, developed after screening more than 900 peptides to identify one that targets senescent ("zombie") cells. These aging cells contribute to inflammation, collagen loss, impaired skin barrier function, and visible skin aging.

Together, they explore the latest research on biological skin age, skin inflammation, barrier repair, collagen production, sensitive skin, retinol, microneedling, hair thinning, scar recovery, and the effects of GLP-1–associated weight loss on skin health. They also discuss why testing complete skincare formulations matters and how longevity science is shaping the future of skincare.

Whether you're a clinician, skincare professional, or simply interested in healthy aging, this episode offers an evidence-informed look at where longevity science and skincare intersect.

Full show notes + references: https://www.drkarafitzgerald.com/fxmed-podcast/

GUEST DETAILS

Dr. Carolina Reis Oliveira* is the CEO and co-founder of OneSkin and a longevity scientist with a Ph.D. in stem cell biology and tissue engineering. Her company develops groundbreaking products to reverse skin aging by targeting senescent cells, one of the central drivers of aging.

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Hormones are about far more than hot flashes.

In this episode of New Frontiers in Functional Medicine, Dr. Kara Fitzgerald is joined by urologist and hormone expert Dr. Kelly Casperson for a conversation that challenges conventional thinking about menopause, hormone replacement therapy (HRT), and healthy aging.

Dr. Casperson explains why menopause may be better understood as a form of hypogonadism, shares the story behind the removal of the FDA's black box warning on vaginal estrogen, and explores the latest evidence on estrogen, progesterone, and testosterone therapy for women.

Topics include:

• Vaginal estrogen and the FDA black box warning

• The lasting impact of the Women's Health Initiative (WHI)

• Estrogen, brain health, and mitochondrial function

• Testosterone therapy for women: science and misconceptions

• Hormone therapy after age 60

• Patient education, body literacy, and informed decision-making

• Exercise, sleep, alcohol reduction, and other foundations of healthy aging

Whether you're a functional medicine practitioner or someone interested in menopause, longevity, and women's health, this evidence-based conversation offers practical insights and a fresh perspective on hormone care.

Show notes and references: https://www.drkarafitzgerald.com/fxmed-podcast/

Full show notes + references: https://www.drkarafitzgerald.com/fxmed-podcast/

GUEST DETAILS

Dr. Kelly Casperson is a board-certified urologic surgeon,CEO and founder of The Casperson Clinic, a modern practice dedicated to hormones and sex medicine, renowned public speaker, sex educator, and host of the top-ranking podcast You Are Not Broken. Dedicated to empowering women, Dr. Kelly blends humor, candor, and science to demystify sexual health, intimacy, and midlife wellness. Through her podcast and online courses, she tackles myths about desire and normalizes conversations around healthy, fulfilling sex. Her work also provides essential education on hormones and midlife health. Connect with Dr. Kelly on Instagram (@kellycaspersonmd) or visit http://kellycaspersonmd.com .

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Resistance training is one of the most powerful interventions for preserving muscle, supporting metabolic health, and promoting healthy aging—but many patients still find it intimidating or confusing. In this episode, Dr. Kara Fitzgerald sits down with exercise physiologist Brad Currier, PhD, to unpack the newly updated ACSM resistance training guidelines and discuss practical approaches for prescribing exercise across the spectrum, from sedentary adults to elite athletes.

In partnership with Timeline, they also review the latest clinical research on Urolithin A, mitochondrial function, muscle recovery, protein, and creatine, offering actionable insights for functional medicine practitioners.

Full show notes + references: https://www.drkarafitzgerald.com/fxmed-podcast/

GUEST DETAILS

Dr. Brad Currier is Manager of Clinical Trials at Timeline, a Swiss biotech company at the forefront of longevity science for over 15 years. With a background in elite athletics, he went on to earn a PhD in muscle physiology, where his research focused on how exercise and nutrition influence aging and performance.

Brad has led numerous clinical trials conducted around the world and published extensively in peer-reviewed journals. He is also the lead author of the American College of Sports Medicine’s new position stand on resistance training prescription, helping shape global guidelines for strength training and healthy aging.

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In this episode of New Frontiers in Functional Medicine, Richard Horowitz joins Kara Fitzgerald to explore the connection between persistent infections, inflammation, and chronic disease.

The discussion highlights emerging research linking Borrelia burgdorferi (Lyme disease) to amyloid production and Alzheimer’s biomarkers, along with the clinical implications of Dr. Horowitz’s MSIDS model. Topics include biofilm persistence, co-infections, treatment resistance, and multi-targeted strategies for addressing complex, chronic conditions such as Lyme disease, ME/CFS, fibromyalgia, and long COVID.

This episode offers clinicians a more integrated framework for evaluating and managing treatment-resistant patients.

Full show notes + references: https://www.drkarafitzgerald.com/fxmed-podcast/

GUEST DETAILS

Richard Horowitz is a board-certified internist and founder of the Hudson Valley Healing Arts Center. For more than 40 years, he has treated over 13,000 patients with Lyme disease and complex chronic illness using both conventional and integrative approaches.

Dr. Horowitz is the developer of dapsone combination therapy and author of the New York Times bestsellers Why Can’t I Get Better? and How Can I Get Better? His newest book, Ending Chronic Illness, explores how his MSIDS model may apply to many chronic diseases beyond Lyme, offering a broader systems-based framework for diagnosis and treatment.

https://cangetbetter.com/

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Montel Williams joins Dr. Kara Fitzgerald to share his decades-long journey with multiple sclerosis (MS), including early neurological symptoms that preceded his diagnosis by years and his recovery following a hemorrhagic stroke. In this episode, created in partnership with MitoQ, the conversation explores MS through a functional medicine lens, with a focus on neuroinflammation, oxidative stress, and mitochondrial dysfunction as key drivers of fatigue, cognitive decline, and disease progression.

Clinicians and health-focused listeners will gain insight into how mitochondrial dysfunction impacts energy, recovery, and brain function, along with practical strategies for differentiating emotional lability from depression in MS. The episode also highlights how mitoquinone (MitoQ) may support mitochondrial health as part of a broader, mechanism-based approach to managing MS and other neuroinflammatory conditions.

Full show notes + references: https://www.drkarafitzgerald.com/fxmed-podcast/

GUEST DETAILS

Montel Williams is an Emmy Award–winning television host, New York Times bestselling author, and health and wellness advocate. A U.S. Navy veteran, he has spent decades educating and inspiring audiences around resilience, longevity, and living well with chronic illness. After being diagnosed with multiple sclerosis (MS) in 1999, Montel adopted a disciplined, science-informed approach to health, emphasizing daily movement, anti-inflammatory nutrition, and integrative care. In addition to his media and writing career, he is actively involved in advancing innovative healthcare solutions, including neuromodulation and trauma-focused therapies.

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Visit https://www.mitoq.com/ and use code DRKARA15 for 15% off your first order.

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Cardiovascular health and longevity are deeply influenced by aging, perimenopause, and systemic changes that extend far beyond cholesterol markers alone.

In this episode of New Frontiers in Functional Medicine, Dr. Kara Fitzgerald sits down with Kiran Krishnan to explore the biology of vascular aging, endothelial dysfunction, and metabolic changes that emerge in midlife and beyond. As estrogen declines during perimenopause, patients often experience shifts in lipid metabolism, weight regulation, and overall metabolic resilience—driving increased cardiovascular risk.

This conversation dives into the critical role of the endothelial glycocalyx, nitric oxide signaling, and the gut microbiome in maintaining vascular integrity and systemic health. Dr. Fitzgerald and Kiran connect the dots between gut health, cardiovascular disease, joint degeneration, and systemic inflammation, offering a systems biology approach that is highly relevant for functional medicine practitioners.

You’ll also hear how targeted interventions—specifically Arterosil, Vascanox, and Cartigenix—can be used synergistically to support endothelial health, nitric oxide production, microbial balance, and joint integrity.

Topics covered include:

- Endothelial glycocalyx dysfunction and cardiovascular risk

- Nitric oxide signaling and vascular health

- Perimenopause, estrogen decline, and metabolic changes

- Gut microbiome influence on cardiovascular and joint health

- Anabolic vs catabolic balance in aging

- Clinical applications for Arterosil, Vascanox, and Cartigenix

- Moving beyond LDL: a systems-based approach to heart health

This episode provides a clinically grounded, functional medicine perspective on aging, cardiovascular disease prevention, and whole-body resilience.

Full show notes + references: https://www.drkarafitzgerald.com/fxmed-podcast/

GUEST DETAILS

Kiran Krishnan is a research microbiologist and health expert with over 20 years of experience in the microbiome and human health space. He is the co-founder of Microbiome Labs, a leading microbiome therapeutics company focused on supporting healthcare professionals.

Kiran has conducted and published research in scientific journals, contributed to academic textbooks, and holds multiple global patents. He is a widely recognized speaker known for translating complex microbiome science into practical, clinically relevant insights.

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Calroy

From circulation to cognition, heart health to joint mobility, Calroy develops clinically validated supplements with patented ingredients that restore and protect the body’s foundations.* Head to http://calroy.com/drkf to learn more about resources and discounts.

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Fatty acids remain one of the most debated areas in clinical nutrition, yet many widely held beliefs may not align with current evidence. In this episode of New Frontiers in Functional Medicine, Dr. Kara Fitzgerald sits down with Bill Harris, PhD, Founder of OmegaQuant Analytics and co-inventor of the Omega-3 Index, to examine the role of omega-3 and omega-6 fatty acids in cardiovascular risk and clinical decision-making.

Learn how to use the Omega-3 Index as a biomarker, interpret atrial fibrillation risk in the context of omega-3 intake, and differentiate between pharmaceutical and dietary interventions. The conversation also explores emerging data on linoleic acid, challenges simplified “good vs bad fat” models, and highlights the complexity of fatty acid metabolism—offering practical guidance for evaluating labs and refining nutrition strategies in practice.

Full show notes + references: https://www.drkarafitzgerald.com/fxmed-podcast/

GUEST DETAILS

Dr. Bill Harris, PhD is a leading omega-3 researcher with over 40 years of experience and more than 400 publications on fatty acids and health. He is the co-inventor of the Omega-3 Index and founder of OmegaQuant Analytics. Dr. Harris has held faculty positions at three medical schools, received NIH funding for omega-3 research, and co-authored American Heart Association statements on fatty acids and heart health. He is ranked among the top 2% of scientists worldwide for research impact.

Email: [email protected]

https://omegaquant.com/

https://www.faresinst.org/

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