What if a human trial of over 1200 patients showed improved mobility and reduced pain in osteoarthritis (OA) patients using a natural combination of boswellia and celery seed extract? What if a second follow-up randomized, placebo-controlled human trial found that within 90 days, this same combination increased OA patients' ability to perform a walk test by over 50%, reduced markers of cartilage degeneration by half and increased markers of cartilage regeneration by half. This is what the research team at Calroy Health Sciences have discovered, putting a tremendous amount of work and financing into studying the effects of the uniquely-developed Cartigenix-HP. Not only that, increased joint space at the end of the trial was clearly visible via radiography, and 90% of the intervention group did not need any "rescue" pharmaceutical medication at the end of the 90 day period (compared with only 20% of the placebo group) and this effect was sustained beyond the end of the trial. I have to say, I am impressed and excited about the potential for this new product to help my patients and I am thinking about other applications like OA prevention and osteoporosis! Listen in to find out more. ~ DrKF

Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast/ for the full list of links and resources.

GUEST DETAILS

Kiran Krishnan, Microbiologist

Kiran Krishnan is a research microbiologist and a health and wellness expert who aims to make complex information understandable to all. He has founded a number of successful health and supplement companies over the last 20 years including co-founding and leading Microbiome Labs, the preeminent, microbiome therapeutics focused brand among healthcare professionals. He is currently a co-founder and partner in 3 other companies that aim to revolutionize wellness care and an advisor to Calroy Health Sciences. He has conducted and published several research studies in scientific journals, has published chapters in scientific textbooks/references books, has global patents and is a sought after speaker on human health and the microbiome.

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Go to Calroy.com/drkf for exclusive resources and discounts on Cartigenix HP.

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We’ve all had patients struggling with chronic conditions like long COVID, fibromyalgia, Lyme disease, and chronic fatigue. Despite all the tools in our functional medicine toolkit, there’s still something missing. How can we truly help them? I’m excited to have Ashok Gupta back on the New Frontiers podcast to offer a new take on healing from chronic illness. He explains that many chronic diseases stem from a malfunction in the brain's threat detection system, where the body overreacts to perceived threats, triggering immune, nervous system, or mood responses, creating a vicious cycle. Ashok shares how retraining the brain and calming the nervous system can reset the body’s response to chronic stress and presents the growing body of research supporting the Gupta Program, including new subjective measurements like CRP showing its impact. What excites me most is the potential for this approach to help some of my toughest-to-treat patients. With more studies emerging, I’m increasingly hopeful this could be a game-changer. It’s a conversation you won’t want to miss! ~DrKF

Check out the show notes at https://tinyurl.com/2t55s3y3 for the full list of links and resources.

GUEST DETAILS

Ashok Gupta

Email: [email protected]

https://guptaprogram.com/

Ashok Gupta is an internationally recognized speaker, filmmaker, and health practitioner who specializes in supporting individuals with chronic illness. After overcoming ME (Chronic Fatigue Syndrome) through his own neuroplasticity research, Ashok developed the Gupta Program in 2007 to help others recover. He has published several medical papers and continues to research chronic conditions, with recent studies demonstrating the effectiveness of the Gupta Program. Ashok is dedicated to advancing holistic approaches to healing and improving outcomes for those facing chronic illness.

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What if the key to reversing chronic disease, slowing cognitive decline, and boosting energy lies in the tiny powerhouses inside your cells—and we’ve finally found a way to protect them?

We know mitochondria power our cells, but did you know they also create oxidative stress as they generate energy? Protecting mitochondrial health is critical—but most antioxidants can't reach inside the mitochondria where protection is needed most—until now. MitoQ, a scientifically advanced, mitochondria-targeted antioxidant developed by visionary researchers in New Zealand penetrates mitochondria up to 90%, offering protection where it's needed most.

In this episode with Dr. Siobhan Mitchell, we dive into how MitoQ is transforming the way we tackle chronic disease, inflammation, and cognitive decline. From improving heart health to supporting brain function, MitoQ is changing the game. It’s something I’m using personally and recommending to most of my patients. Listen in to discover how this powerful tool can help you support your patients at the cellular level—before symptoms even appear. ~DrKF

Check out the show notes at https://tinyurl.com/2t55s3y3 for the full list of links and resources.

GUEST DETAILS

Dr Siobhan Mitchell, PhD., MitoQ Chief Scientific Officer

Email: [email protected]

Holding a PhD in neuroscience from SUNY Albany, Siobhan Mitchell has also completed a post-doctoral fellowship on brain aging at the University of Washington. She has over 15 years of clinical research experience, seven patents on mood and cognitive food products, and has authored over 50 papers on aging, brain health, nutrition, metabolic health and more.

With a personal passion for brain aging research, Siobhan has worked on metabolic and skin health, appetite, sports physiology and of cellular health –which she now focuses on as the Chief Scientific Officer for research-backed cellular health company, MitoQ – creators of the world’s first mitochondria-targeted antioxidant.

THANKS TO OUR SPONSOR

OFFER FOR NEW FRONTIERS LISTENERS

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CONNECT WITH DrKF

Want more? Join our newsletter here: https://www.drkarafitzgerald.com/newsletter/ Or take our pop quiz and test your BioAge! https://www.drkarafitzgerald.com/bioagequiz

YouTube: https://tinyurl.com/hjpc8daz

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Join me for a fascinating conversation around an exciting breakthrough in dementia detection that’s offering real hope for early intervention. Dr. Hans Frykman, Chief Scientific Officer at Neurocode Laboratories, is here to share groundbreaking insights into cutting-edge biomarkers that can identify pathology associated with Alzheimer's disease before symptoms even appear. What’s even more fascinating is how these same tools are revealing neuroinflammation caused by infections, including COVID, Lyme disease, and mold exposure—issues that are incredibly relevant in functional medicine today. The assays Dr. Frykman and his team have developed, and continue to research, are transforming the way we think about diagnosing and addressing neurodegeneration. We’re talking about a potential game-changer that allows us to intervene earlier, reverse damage, and ultimately improve the trajectory of these conditions. This is an extraordinary time in science and medicine, and the work we’re discussing today is at the forefront of it all. Don’t miss out on how this could reshape your practice. ~DrKF

Check out the show notes at https://tinyurl.com/2t55s3y3 for the full list of links and resources.

GUEST DETAILS

Dr. Hans Frykman, MD PhD FRCPC

Hans Frykman MD, Ph.D., FRCPC is the founder, CEO, and medical director of BC Neuroimmunology Lab located in the UBC hospital on the University of BC campus in Vancouver BC. He is the medical director for Lykke Lab a genetics laboratory also on the University of BC campus. Also, he is the CSO for Neurocode Lab Inc. in Bellingham WA, a high-complexity, specialty lab focused on neuroimmunology and biomarkers in neurodegeneration. Dr. Frykman has a clinical faculty position at the University of British Columbia, Faculty of Medicine, Division of Neurology.

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Why MitoQ’s mitochondria-targeting is a critical step for your healthspan and longevity strategy. https://tinyurl.com/2b5benmd

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Join our newsletter here: https://www.drkarafitzgerald.com/newsletter/ Or take our pop quiz and test your BioAge! https://www.drkarafitzgerald.com/bioagequiz

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We’re witnessing an exciting shift in how we understand gut health and disease—and it’s all thanks to the powerful metabolites produced by the microbiome, like short-chain fatty acids (SCFAs) and secondary bile acids. In today’s episode, Dr. Tom Fabian shares groundbreaking insights into how these postbiotics influence intestinal barrier integrity, immune balance, and even muscle regeneration. These compounds are also connected to key processes like glucose metabolism and healthy aging. What’s truly fascinating is how this science is opening up new frontiers in treating IBS, metabolic conditions, and chronic gut issues. With the upcoming launch of Diagnostic Solution Laboratories’ StoolOMX test, an add-on to the GI-MAP, we now have a tool to measure these metabolites in clinical practice, making personalized and effective treatments more attainable. This is a pivotal moment in functional medicine that you don’t want to miss. ~DrKF

FOLLOW ALONG WITH THE CONVERSATION!

Get the Updated GI-MAP® Guide with StoolOMX™ Insights! The new GI-MAP® Guide now includes StoolOMX™ insights on bile acids and short-chain fatty acids, enhancing your understanding of IBS, IBD, and gut motility. Refine treatment strategies and optimize patient care with this essential resource. Download now! https://tinyurl.com/5ehysjp7

Check out the show notes at https://tinyurl.com/2t55s3y3 for the full list of links and resources.

GUEST DETAILS

Thomas Fabian, PhD, CNTP

Email: [email protected]

Dr. Fabian is a leading expert on the role of the microbiome in health, immune function, chronic disease, and aging. As a translational scientist, his primary focus is on the clinical application of microbiome research in the integrative and functional medicine space. He received his PhD in molecular biology from the University of Colorado, Boulder, and has worked as a biomedical researcher in the biotechnology industry, and more recently, as a consultant in the microbiome testing field. Currently, Dr. Fabian serves a consultant and science advisor with Diagnostic Solutions Laboratory, and he is also a Science Advisory Board member with Designs for Health. In addition, he is certified as a Nutrition Therapy Practitioner by the Nutrition Therapy Institute in Denver.

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Phone: 877-485-5336

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It’s very difficult (often impossible) to completely avoid many of the environmental toxins that can cause harm - like air pollution and forever chemicals that contaminate our water and food supply. But Drs. Bob and Rosalind Wright at Mount Sinai have a hopeful solution to this dilemma. They are pioneering the study of “resiliency factors,” not just “risk factors,” that can offset the risks of harmful exposures. It’s a fresh and welcome take on exposomics that I am very excited to share with you. For instance - did you know that omega-3 intake during pregnancy can protect against the development of asthma in the child, even if the child is exposed to known risk factors for asthma? Or that positive relationships (ones that create a sensitive, positive, caregiving environment) have been shown to potentially mitigate the effects of environmental toxins? As a practitioner, I am always looking to empower patients with real solutions to the health challenges we inevitably face and I hope you enjoy this conversation as much as I did. ~DrKF

Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast/ for the full list of links and resources.

GUEST DETAILS

Dr. Rosalind J. Wright, MD, MPH and Robert O. Wright, MD, MPH

Icahn School of Medicine at Mount Sinai https://icahn.mssm.edu/

Dr. O. Robert Wright is the Ethel H. Wise Chair of Environmental Medicine at Mount Sinai and co-founder of the Institute for Exposomic Research. His research links environmental exposures, like those tracked in the PROGRESS cohort, with the developmental origins of diseases.

Dr. Rosalind J. Wright is Dean for Public Health at Icahn School of Medicine and Co-Director of the Institute for Climate Change, Environmental Health, and Exposomics. A pioneer in environmental health, she studies how early-life exposures influence chronic diseases and has been NIH-funded for over 23 years. She also mentors the next generation of clinical scientists.

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Try QUALIA NAD+ for up to 50% off! Visit https://www.qualialife.com/kara15 and use code KARA15 at checkout for an additional 15% off your entire purchase.

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CONNECT with DrKF

Want more? Join our newsletter here: https://www.drkarafitzgerald.com/newsletter/ Or take our pop quiz and test your BioAge! https://www.drkarafitzgerald.com/bioagequiz

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Better Broths and Healing Tonics book: https://tinyurl.com/3644mrfw

Join me and Dr. Colleen Cutcliffe, my brilliant friend, scientist, and the powerhouse CEO of Pendulum, for our deepest dive yet into all things Akkermansia. This free-flowing conversation will take your understanding of this extraordinary strain to a whole new level. We’ll explore Akkermansia’s pivotal role in metabolic health—think cravings, weight regulation, A1C—and why we’re deficient in the first place. Plus, we’ll discuss its connection to stress, anxiety, and even neurodegenerative diseases. We’ll also dive into the hotly debated topic of Akkermansia’s impact on MS, unpacking both sides of the controversy. And, we’ll touch on its promising influence on hormonal balance, from infertility to menopause.

As someone who's deeply invested in science, I’m personally bullish on Akkermansia and trust Pendulum’s products as part of my own foundational health stack. With groundbreaking science and fresh insights, this episode will change the way you approach your practice. ~DrKF

Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast/ for the full list of links and resources.

GUEST DETAILS

Colleen Cutcliffe, PhD, Co-Founder and CEO of Pendulum Therapeutics

Colleen Cutcliffe is the Chief Executive Officer and co-founder of Pendulum. She has more than 25 years of experience leading and managing biology teams in academia, pharmaceuticals, and biotechnology. Prior to starting Pendulum, Colleen was the senior manager of biology at Pacific Biosciences and a scientist at Elan Pharmaceuticals. Colleen completed her postdoctoral studies at Northwestern’s Children’s Memorial Hospital. Colleen received her Ph.D. in Biochemistry and Molecular Biology from Johns Hopkins University and her B.A. in Biochemistry from Wellesley College.

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Want more? Join our newsletter here: https://www.drkarafitzgerald.com/newsletter/ Or take our pop quiz and test your BioAge! https://www.drkarafitzgerald.com/bioagequiz

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For many struggling with depression, the message they often hear from traditional care is "just live with it" or "there’s nothing more we can do." In today’s episode, we’re challenging that narrative. I’m joined by Dr. Achina Stein and Silvia Covelli from the Healing Depression Project - a groundbreaking residential treatment and research program. Dr. Stein, a functional psychiatrist, and Silvia, who’s personally battled chronic depression, are offering a fresh approach to treatment-resistant depression. Their in-residence program, launching in March, takes a whole-person approach—integrating nutrition, lifestyle changes, trauma healing, and community support. And with research built into the program, they’re not just helping patients; they’re also paving the way to make this approach more accessible for everyone. If you’re ready to rethink depression treatment, this episode is for you. ~DrKF

Check out the show notes at https://tinyurl.com/2t55s3y3 for the full list of links and resources.

GUEST DETAILS

Dr. Achina Stein DO, IFMCP and Silvia Covelli, creator of Healing Depression Project

Website: https://www.healingdepressionproject.com/

Schedule a free call with Silvia or Dr. Stein at: https://tinyurl.com/2z3dxtv7

NOW ACCEPTING APPLICATIONS

The team at Healing Depression Project is thrilled to announce an upcoming 45-Day Depression Recovery Program starting on March, 2025.

The program includes a 30-day in-person retreat at a deluxe and serene ranch in Austin, TX, followed by a 15-day at-home integration phase, ensuring sustainable improvement.

Scholarship Opportunities Available: Participants who are invited to apply can also apply for a scholarship program. If a scholarship is awarded, it can cover up to 80% of the total investment. Schedule a call for details: https://tinyurl.com/2z3dxtv7

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THANK YOU TO OUR SPONSORS

DIAMOND

DUTCH: https://tinyurl.com/4anbz7b3

Biotics Research: https://www.bioticsresearch.com/

Integrative Therapeutics: https://tinyurl.com/4emwj48z

GOLD

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TimeLine Nutrition: https://tinyurl.com/bdzx2xms

Vibrant Wellness: https://www.vibrant-wellness.com/

EXCLUSIVE OFFERS FROM OUR SPONSORS

Try QUALIA NAD+ for up to 50% off! Visit https://www.qualialife.com/kara15 and use code KARA15 at checkout for an additional 15% off your entire purchase.

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Join our newsletter here: https://www.drkarafitzgerald.com/newsletter/ Or take our pop quiz and test your BioAge! https://www.drkarafitzgerald.com/bioagequiz

YouTube: https://tinyurl.com/hjpc8daz

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Facebook: https://www.facebook.com/DrKaraFitzgerald/

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We’re doing a deep dive into NAD, a molecule that has received a lot of attention but still confuses many of us, clinicians included. My guest today is able to unpack the complexities of NAD in a way you’ll find extremely illuminating and useful. I’m excited to have Dr. Greg Kelly Senior Director of Product Development at Qualia, back with us, explaining how NAD is foundational for energy, longevity, and overall cellular health. Dr. Kelly brings clarity to how NAD influences mitochondrial function, DNA repair, and pretty much all of the hallmarks of aging. Yet, problematically, it declines as we age. This episode will cover different NAD compounds, how deficiency might present clinically, and how to measure NAD reliably. Have a listen and get ready to expand your understanding around this essential compound. ~DrKF

Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast/ for the full list of links and resources.

GUEST DETAILS

Dr. Greg Kelly

Dr. Greg Kelly is Senior Director of Product Development at Neurohacker Collective, naturopathic physician (N.D.), and author of the book Shape Shift. He was the editor of the journal Alternative Medicine Review and has been an instructor at the University of Bridgeport in the College of Naturopathic Medicine, where he taught classes in Advanced Clinical Nutrition, Counseling Skills, and Doctor-Patient Relationships. Dr. Kelly has published hundreds of articles on natural medicine and nutrition, contributed three chapters to the Textbook of Natural Medicine, and has more than 30 journal articles indexed on Pubmed. His areas of expertise include nootropics, anti-aging and regenerative medicine, weight management, sleep and the chronobiology of performance and health.

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EXCLUSIVE OFFER FOR NEW FRONTIERS LISTENERS

Visit http://qualialife.com/drkarafitzgerald to try Qualia NAD+ up to 50% off and use code DRKARAFITZGERALD at checkout for an additional 15% off your entire purchase!

CONNECT WITH DrKF

Want more? Join our newsletter here: https://www.drkarafitzgerald.com/newsletter/ Or take our pop quiz and test your BioAge! https://www.drkarafitzgerald.com/bioagequiz

YouTube: https://tinyurl.com/hjpc8daz

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Facebook: https://www.facebook.com/DrKaraFitzgerald/

DrKF Clinic: Patient consults with DrKF physicians including Younger You Concierge: https://tinyurl.com/yx4fjhkb

Younger You Group Program: https://tinyurl.com/4hvusavw

Younger You book: https://tinyurl.com/mr4d9tym

Better Broths and Healing Tonics book: https://tinyurl.com/3644mrfw

After my conversation with Dr. Greg Fahy in August, I realized that I had additional questions that we didn't have time to address the first time around. Importantly, since here I am studying the effects of dietary and lifestyle interventions on aging, I wanted to know his thoughts on the dietary components of the TRIMM study and beyond. Dr. Fahy shares his thoughts on my question and some others on side effects on different medication and supplement interventions, the mechanism by which he thinks the restoration of hair color occurred in some of his study participants, and how to think about (and feel motivated about!) incorporating safe exercise. This brief bonus podcast episode is just right for squeezing into your holiday schedule. Enjoy! ~DrKF

Missed the first conversation with Dr. Greg Fahy? Catch up on the original episode for key insights and context before diving into the follow-up! https://tinyurl.com/bdcwktbj

Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast for the full list of links and resources.

GUEST DETAILS

Greg Fahy, PhD

Intervene Immune: https://interveneimmune.com/who-we-are/

Email: [email protected]

Dr. Greg Fahy received his Ph.D. in Pharmacology and Cryobiology from the Medical College of Georgia in 1977. A world-renowned cryobiologist, Dr. Fahy is the chief science officer and co-founder of Intervene Immune, where he leads groundbreaking research on thymus regeneration and combating age-related immune decline. He designed and led the TRIIM trial, the first to demonstrate both thymus rejuvenation and the reversal of human epigenetic age. His work has been pivotal in advancing aging research, resulting in successful follow-up trials like TRIIM-XA, and further planned studies aimed at refining and expanding these innovative treatments.

WORK WITH OUR TEAM

At Dr. Fitzgerald’s New Frontiers Functional Medicine and Nutrition Clinic, we specialize in personalized root cause medicine, offering both in person and virtual consultations. Our team of functional medicine physicians and nutritionists is trained in the research based, Younger You Longevity Protocol and experienced in working with many conditions, including gastrointestinal, immune, cardiovascular, metabolic, brain, and many more, and in supporting those seeking optimal wellness. Ready to explore how we can help you feel your best? Visit https://tinyurl.com/yx4fjhkb to book a free15-minute Discovery Call today.

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Join our newsletter here: https://www.drkarafitzgerald.com/newsletter/ Or take our pop quiz and test your BioAge! https://www.drkarafitzgerald.com/bioagequiz

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