It was a pleasure to sit down with Dr. Nir Barzilai for a conversation that turned out to be both lively and thought-provoking. His decades of research on centenarians, biological age, and the hallmarks of aging have shaped how we think about longevity—and what’s possible when we start targeting aging itself, not just individual diseases.

We get into the science behind why some people live 20–30 years longer and healthier, and what it means to measure the biological age of individual organs. But we also hit a few sparks—especially when it comes to nutraceuticals and the role of metformin in prevention. I don’t agree with everything you’ll hear, and I followed up with Dr. Barzilai afterward to unpack some of the more provocative claims. We may just need a second round for this one... stay tuned.

Check out the show notes at www.drkarafitzgerald.com/fxmed-podcast/ for all the relevant links and resources. ~DrKF

Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast/ for the full list of links and resources.

GUEST DETAILS

Nir Barzilai M.D.

Director of the Einstein Institute for Aging Research

Professor of Medicine and Genetics

President of the Academy for Health & Lifespan Research

Website: https://einsteinmed.edu/faculty/484/nir-barzilai

Email: [email protected]

Dr. Nir Barzilai is a pioneer in aging science, known for his work on centenarians, the biology of aging, and the TAME trial. He is Director of the Institute for Aging Research at Albert Einstein College of Medicine and author of Age Later and has published over 330 papers.

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I’ve been watching the science behind Calocurb evolve over the last year, and I have to say—this is one of the most exciting clinical tools I’ve seen emerge in the metabolic space in quite some time. A hops-derived compound that stimulates endogenous GLP-1, CCK, and PYY—without a prescription or injection? That’s a big deal, especially for patients struggling with appetite regulation, weight plateaus, or the aftermath of GLP-1 discontinuation.

In this episode, I sit down with Sarah Kennedy, founder of New Zealand-based Calocurb, to talk about the years of government-funded research that led to this discovery, the remarkable clinical outcomes they’ve seen so far, and how I’ve personally used it in my practice with excellent results. If you’re looking for science-backed, natural strategies to support appetite control, fasting, or GLP-1 transitions—this one’s worth a listen. ~DrKF

Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast/ for the full list of links and resources.

GUEST DETAILS

Sarah Kennedy, Founder and CEO of Calocurb Ltd.

Email: [email protected]

LinkedIn: https://www.linkedin.com/in/sarah-kennedy-0a840b13/

Sarah Kennedy, BVSc, is a veterinarian and health industry leader with 20+ years in nutrition science and innovation. Now CEO of Calocurb, she brings a unique perspective on natural GLP-1 activation—bridging plant-based research, gut physiology, and clinical application.

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Join Dr. Kara Fitzgerald and leading experts *LIVE on Sept 17–19, 2025* for a free virtual Masterclass on redefining healthcare & longevity through the lens of science-backed, systems-based approach. Register now: https://www.functionalmedicineislongevitymedicine.com/

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In this very special episode, I have the privilege of turning the tables on Dr. Kara Fitzgerald as we celebrate 10 years of the New Frontiers podcast. I’ve been honored to walk alongside Kara on much of this journey—as a colleague, a collaborator, a mentee, and a friend—and it’s been incredible to witness the evolution of both her work and the field itself.

Together, we reflect on the stories, science, and people who have shaped this podcast—and the remarkable growth of epigenetics, personalized medicine, and functional medicine along the way. From early conversations around methylation and aging to hosting pioneers like Dr. Jeff Bland, Dr. Sidney Baker, and Dr. Charles Serhan, New Frontiers has become a living archive of how this field has moved forward.

As we talked about during the conversation: “Everybody is a piece of this ecosystem, and everybody has their role... It’s really cool to be part of that community.” This episode is a celebration of that collective journey—and a look at where we’re headed next. ~Romilly Hodges MS CNS

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This is a really exciting conversation with Dr. Davide D’Amico from Timeline, where we’re taking a closer look at Urolithin A and heart health. It should come as no surprise that this mitochondrial wonderkin of a nutrient is showing promise here—especially when you consider that 40% of the heart’s weight is mitochondria. That’s an extraordinary factoid, and one that really shifts how we think about aging in the cardiovascular system.

What’s particularly compelling in this new preclinical research is that restoring mitochondrial function may do more than just improve ejection fraction. It may also have ripple effects on other hallmarks of aging—like chronic inflammation, cellular stress signaling, and impaired autophagy. I’m thrilled Timeline is continuing to invest in both preclinical and clinical research on this front—and yes, I’m totally nerding out over what they’re up to. ~DrK

Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast/ for the full list of links and resources.

GUEST DETAILS

Davide D'Amico, PhD: Director of Discovery and Translational Research at Timeline.

With over 15 years of experience in mitochondrial and aging biology, he contributed to developing Urolithin A as a science-backed, clinically validated nutritional product to enhance mitochondrial and muscle health.

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Timeline: http://Timeline.com/kara10

Email: [email protected]

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This episode is a little different from what we usually cover on New Frontiers, but it’s one I couldn’t wait to bring to you. I’ve been thinking a lot about how we—as clinicians—are supposed to keep up in this era of high-throughput technology. We’re swimming in data: labs, multi-omics, diet logs… and an ever-growing stream from wearables. There’s just so much coming at us, and too often, we’re awash in a sea of information without adequate interpretive power.

That’s why this conversation with Dr. Rana el Kaliouby felt so important. She’s not just an AI scientist—she’s a visionary and a total badass. She’s building technology that doesn’t just process data, but actually helps us become better clinicians and better humans. We get into the ethics, the potential, the parenting implications—and yes, a personal story about a tragedy in my own hometown that made this all hit very close to home. This one’s powerful, and I hope it sparks the same questions and inspiration for you as it did for me. ~DrKF

TRIGGER WARNING

This episode touches on sensitive topics, including gun violence and suicide, in the context of empathy, mental health, and technology. If you or someone you know is struggling, please seek help. We share this with care and hope it offers support and perspective.

Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast/ for the full list of links and resources.

GUEST DETAILS

Dr. Rana el Kaliouby: http://www.ranaelkaliouby.com

Managing Partner, Blue Tulip Ventures: http://www.bluetulip.vc

Host, Pioneers of AI Podcast: https://www.pioneersof.ai/

Author of Girl Decoded

Dr. Rana el Kaliouby is an Egyptian-American AI scientist, entrepreneur and investor. She is co-founder and Managing Partner of Blue Tulip Ventures, where she invests in startups building Human-Centric AI, and host of the Pioneers of AI podcast. Prior to that, Rana founded her company Affectiva out of MIT, where she pioneered the field of Emotion AI, and successfully exited the company in 2021. She holds a Ph.D. from the University of Cambridge and a Post Doctorate from MIT.

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In many ways, the legal side of functional medicine can feel like the Wild West—uncertain, unregulated, and full of risks. The reality is, we all want to have our practices legally buttoned up, but navigating the legal landscape can feel overwhelming—and expensive. What Scott Rattigan, creator of Functional Lawyer, shares in this episode is a real game-changer. He not only breaks down the complexities of the legal side of things but also offers real solutions for us—solutions that can make sure we're covered without the stress and uncertainty that often comes with it. Whether you're just starting out or growing your established practice, you're going to get actionable insights on how to avoid common legal pitfalls, protect your practice, and actually move forward with confidence. It’s a topic that’s been an unmet need for so long, and I'm so excited to bring this to you. ~DrKF

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GUEST DETAILS

Scott Rattigan, JD

Founder: Functional Lawyer: https://www.functionallawyer.com/kf

Co-founder: Origins Incubator - https://www.originsincubator.com/

The Junto Podcast Playlist: https://fxmedlaw.com/junto-youtube

LinkedIn: https://www.linkedin.com/in/scott-rattigan/

Email: [email protected]

Phone: 941-229-0928

Scott Rattigan, JD, is the founder of Functional Lawyer, offering flat-rate legal solutions to help practitioners protect their licenses and grow their businesses. Inspired by helping his wife build her functional medicine practice, Scott provides high-quality legal support for health coaches, doctors, and more. He’s an attorney, internationally recognized speaker, host of The Junto with Scott Rattigan, bestselling author of The Practice of Telemedicine, and co-founder of the practice success software ReveliaDx.

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I’ve been looking forward to sharing this conversation with you because it’s one I’m truly passionate about. Today, we’re diving into the DunedinPACE epigenetic clock with one of its creators, the brilliant Dan Belsky. It’s a tool I use regularly with my patients, and one that’s transforming how we approach aging and interventions. While this show is a bit more technical than usual, the science is fascinating, and the real-world applications are incredibly valuable. This isn’t just about theory—it’s about practical insights that can change how we measure aging and track the effectiveness of the treatments we offer. Stick with us, and you’ll walk away with actionable knowledge that can make a difference in your practice. ~DrKF

Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast/ for the full list of links and resources.

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Daniel W Belsky, PhD

Website: www.belskylab.com

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What if a human trial of over 1200 patients showed improved mobility and reduced pain in osteoarthritis (OA) patients using a natural combination of boswellia and celery seed extract? What if a second follow-up randomized, placebo-controlled human trial found that within 90 days, this same combination increased OA patients' ability to perform a walk test by over 50%, reduced markers of cartilage degeneration by half and increased markers of cartilage regeneration by half. This is what the research team at Calroy Health Sciences have discovered, putting a tremendous amount of work and financing into studying the effects of the uniquely-developed Cartigenix-HP. Not only that, increased joint space at the end of the trial was clearly visible via radiography, and 90% of the intervention group did not need any "rescue" pharmaceutical medication at the end of the 90 day period (compared with only 20% of the placebo group) and this effect was sustained beyond the end of the trial. I have to say, I am impressed and excited about the potential for this new product to help my patients and I am thinking about other applications like OA prevention and osteoporosis! Listen in to find out more. ~ DrKF

Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast/ for the full list of links and resources.

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Kiran Krishnan, Microbiologist

Kiran Krishnan is a research microbiologist and a health and wellness expert who aims to make complex information understandable to all. He has founded a number of successful health and supplement companies over the last 20 years including co-founding and leading Microbiome Labs, the preeminent, microbiome therapeutics focused brand among healthcare professionals. He is currently a co-founder and partner in 3 other companies that aim to revolutionize wellness care and an advisor to Calroy Health Sciences. He has conducted and published several research studies in scientific journals, has published chapters in scientific textbooks/references books, has global patents and is a sought after speaker on human health and the microbiome.

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We’ve all had patients struggling with chronic conditions like long COVID, fibromyalgia, Lyme disease, and chronic fatigue. Despite all the tools in our functional medicine toolkit, there’s still something missing. How can we truly help them? I’m excited to have Ashok Gupta back on the New Frontiers podcast to offer a new take on healing from chronic illness. He explains that many chronic diseases stem from a malfunction in the brain's threat detection system, where the body overreacts to perceived threats, triggering immune, nervous system, or mood responses, creating a vicious cycle. Ashok shares how retraining the brain and calming the nervous system can reset the body’s response to chronic stress and presents the growing body of research supporting the Gupta Program, including new subjective measurements like CRP showing its impact. What excites me most is the potential for this approach to help some of my toughest-to-treat patients. With more studies emerging, I’m increasingly hopeful this could be a game-changer. It’s a conversation you won’t want to miss! ~DrKF

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If you are a practicing clinician with patients who suffer from an inflammatory condition, you are entitled to free access to one of the world's foremost neuroplasticity programs, and the only one with independent randomized controlled trial data.

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GUEST DETAILS

Ashok Gupta

Email: [email protected]

https://guptaprogram.com/

Ashok Gupta is an internationally recognized speaker, filmmaker, and health practitioner who specializes in supporting individuals with chronic illness. After overcoming ME (Chronic Fatigue Syndrome) through his own neuroplasticity research, Ashok developed the Gupta Program in 2007 to help others recover. He has published several medical papers and continues to research chronic conditions, with recent studies demonstrating the effectiveness of the Gupta Program. Ashok is dedicated to advancing holistic approaches to healing and improving outcomes for those facing chronic illness.

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What if the key to reversing chronic disease, slowing cognitive decline, and boosting energy lies in the tiny powerhouses inside your cells—and we’ve finally found a way to protect them?

We know mitochondria power our cells, but did you know they also create oxidative stress as they generate energy? Protecting mitochondrial health is critical—but most antioxidants can't reach inside the mitochondria where protection is needed most—until now. MitoQ, a scientifically advanced, mitochondria-targeted antioxidant developed by visionary researchers in New Zealand penetrates mitochondria up to 90%, offering protection where it's needed most.

In this episode with Dr. Siobhan Mitchell, we dive into how MitoQ is transforming the way we tackle chronic disease, inflammation, and cognitive decline. From improving heart health to supporting brain function, MitoQ is changing the game. It’s something I’m using personally and recommending to most of my patients. Listen in to discover how this powerful tool can help you support your patients at the cellular level—before symptoms even appear. ~DrKF

Check out the show notes at https://tinyurl.com/2t55s3y3 for the full list of links and resources.

GUEST DETAILS

Dr Siobhan Mitchell, PhD., MitoQ Chief Scientific Officer

Email: [email protected]

Holding a PhD in neuroscience from SUNY Albany, Siobhan Mitchell has also completed a post-doctoral fellowship on brain aging at the University of Washington. She has over 15 years of clinical research experience, seven patents on mood and cognitive food products, and has authored over 50 papers on aging, brain health, nutrition, metabolic health and more.

With a personal passion for brain aging research, Siobhan has worked on metabolic and skin health, appetite, sports physiology and of cellular health –which she now focuses on as the Chief Scientific Officer for research-backed cellular health company, MitoQ – creators of the world’s first mitochondria-targeted antioxidant.

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