Dr. Gabrielle Lyon argues we've been focusing on the wrong idea for 50 years…the problem isn't that we're over-fat, it's that we're under-muscled.

Skeletal muscle makes up 40% or more of your body and is an underrecognized endocrine organ that secretes myokines (signaling molecules) when contracted, impacting the brain, liver, pancreas, and truly every body system. Yet skeletal muscle wasn't even considered an organ system until about 25 years ago!

The diseases we think of as obesity-related—type 2 diabetes, Alzheimer's, cardiovascular disease—are actually diseases of skeletal muscle first, decades before symptoms appear. When Dr. Lyon asked a PCOS expert what body fat percentage contributes to infertility, the answer shocked her: "It has nothing to do with body fat percentage—it has everything to do with the fat infiltrated into the muscle, the intermuscular adipose tissue (IMAT)."

The new US Dietary Guidelines (which Dr. Lyon witnessed being announced on stage) recommend 1.2 to 1.6 grams of protein per kg for the first time in history, a tremendous change based on randomized controlled trials instead of epidemiology. Her mentor, Dr. Donald Layman, wrote the protein portion of the guidelines, and 90% of those guidelines are reflected in her new book, Forever Strong Playbook, released on January 27th of this year.

Over 30 million women in the US deal with some form of pelvic floor dysfunction…nearly 1 in 4 women.

In this episode, I speak with Jana Danielson, founder of Lead Pilates and creator of the Cooch Ball (and no, that's not a typo!), who reveals shocking realities about the urinary incontinence product industry.

Even though they'll top $24 billion in profit this year, 9 out of 10 people could fix incontinence if they learned to breathe correctly and stopped being such literal "tight asses" (her words, not mine).

Listen to the podcast to hear all of Jana's insights.

In this podcast, Jana and I discuss:

• Why over 30 million US women deal with pelvic floor dysfunction—nearly 1 in 4 women—and the urinary incontinence product industry will top $24 billion this year

• The pelvic floor can be too tight (hypertonic) or too loose (hypotonic)—too tight causes one set of symptoms, while too loose causes another

• About 90% of erectile dysfunction is actually a fitness/movement issue, not medical…when pelvic floor muscles get too tight, blood flow to the penis cannot happen

• There are four grades of prolapse; some grades can be completely reversed, while others require surgery. Jana explains the anatomical and energetic underpinnings of prolapse

• The diaphragm is the "roof" and the pelvic floor is the "floor" of your core—doing 10-12 diaphragmatic breaths daily will wake up the pelvic floor tissues, like giving it CPR

• The pudendal nerve's Latin root means "ashamed"—it's the main sensory and motor nerve from your brain to your genitals/pelvic floor in both men and women

• You can do all the fancy medical spa pelvic floor contractions, but without proper breathing, your results won't last—you have to create the environment for the solution to work

• When you inhale into your diaphragm, the pelvic floor is in its restful/descension phase—when you exhale, it's in its lift phase, a key distinction for pelvic floor health

• Posture plays a considerable role in pelvic floor health: mechanically holding weight in an optimal position takes unnecessary stress off your pelvic floor

• If you chug water rapidly, your body will excrete more of it. Sip tiny amounts throughout the day so cells absorb hydration properly and your bladder functions optimally

Periodontist Dr. Al Danenberg was diagnosed with incurable bone marrow cancer (multiple myeloma) in September 2018 and given 3 to 6 months to live. His oncologist wanted to start chemotherapy the next day, but Dr. Al rejected chemo and instead focused on natural methods to help his body heal.

While Dr. Danenberg has since passed on, he survived most of his remaining years with an outstanding quality of life, shocking his oncologist and maintaining such good health that his gut microbiome diversity was in the 97th percentile.

In this episode, filmed in March 2023, Dr. Al discusses his diagnosis and why he believed his cancer stemmed from toxic exposures in dental school in the late 1960s and early 1970s. He emphasizes that all cancers are diseases of lifestyle, and that there are very few wild animals with cancer and very few primal societies with gum disease, tooth decay, chronic diseases, or cancer.

Dr. Al also explores a few somewhat shocking oral health ideas, including why dental plaque is actually healthy! He backs this surprising claim with three critical roles plaque plays in the mouth: it acts as a gatekeeper, allowing minerals from saliva to remineralize teeth; it contains chemical buffers that keep pH at ~5.5 to prevent decay; and it produces hydrogen peroxide that kills pathogenic bacteria trying to invade.

I know you'll enjoy this episode with the late Dr. Al Danenberg.

In this podcast, I am speaking with Dr. Reef Karim, a leading expert in human behavior, who has dedicated his life to educating, entertaining, and helping people understand themselves better. Dr. Karim is a double board certified psychiatrist, addiction medicine physician, relationship expert, writer, speaker (with recurring appearances on Oprah, Dr. Oz, CNN, Larry King Live, Dr. Phil, Anderson Cooper, and many others), comedic host, and media personality.

We will discuss the "victim mindset" and how it appears to be rapidly spreading in the younger generations across the Western world, the difference between victimhood and vulnerability, conformism vs. authenticity/courage, healing from trauma, self-sabotaging behavior, and how to grow into the fullest expression of your own capacities and authentic self.

Dr. Izabella Wentz is a renowned pharmacist focused on thyroid health. In this episode, she reveals a shocking pattern: about 90% of people with Hashimoto's have alterations in how much cortisol they release throughout the day.

They struggle with brain fog, chronic fatigue, and sleep issues—tired all day, wired at night—even when they're on thyroid medications.

She's discovered something fascinating about "adrenal fatigue" that challenges both the old naturopathic model and the skeptics.

Your adrenals aren't damaged or lazy…they're perfectly capable of producing hormones. "Adrenal fatigue" is an intelligent adaptive response where your body down-regulates cortisol production to protect itself from chronic stress, essentially saying, "This is unrealistic, we can't pump out high amounts of cortisol all the time."

After being forced to find solutions during years of severe sleep deprivation with her son, Dr. Wentz developed a 4-week protocol that has now helped thousands of people. By week two, people report their anxiety dropping from an 8 to a 2. By week four, their libido returns and they feel transformed, all without hormones, complicated testing, or bags full of supplements.

In this episode, Dr. Bonnie Kaplan shares a statistic that should stop everyone in their tracks: 50% of people will be diagnosed with a mental disorder at some point in their lifetime. When she was a kid in the 1950s, that rate was 1% or less.

As a professor emeritus at the University of Calgary and co-author of The Better Brain, Dr. Kaplan has spent decades researching what went wrong. She shares the case of "Andrew," a 10-year-old with childhood psychosis who recovered on micronutrients when six months of psychiatric care failed…yet his doctor refused to try it with other patients because "it's not part of clinical practice guidelines."

This episode was initially released in July 2022

This interview took place on a historic day: the FDA removed the black box warning for HRT (hormone replacement therapy) after 20 years. My guest, Dr. Mariza Snyder, author of The Perimenopause Revolution, explains why this matters and why women have been suffering needlessly for decades while doctors dismissed their symptoms as "just aging" or "just stress."

Perimenopause is the 4 to 10-year transition where hormones wildly fluctuate before menopause, and Dr. Snyder calls it "the window of vulnerability." She uses a powerful metaphor: imagine estrogen as your brain's master CEO who shows up like clockwork from 9 AM to 6 PM for 30 years.

Then, suddenly, without warning, it shows up at 2 PM one day and leaves at 11 PM, then shows up at 6 AM the next day and leaves at 11 AM. Your brain scrambles trying to regulate energy, neurotransmitters, sleep, mood, and cravings.

The most compelling insight of our conversation is a Mayo Clinic study that found 84% of menopausal women don't seek care. Why? Because they feel judged in the doctor's office.

Dr. Snyder wrote her book as the roadmap she desperately needed when she started her own perimenopause journey, connecting symptoms to future health outcomes and providing practical solutions beyond just "you're getting older."

In this episode with Dr. John Lieurance, he drops a bombshell in the first few minutes: "I take hundreds of milligrams [of melatonin] every night, and I've gone through months and months of taking it religiously."

While most melatonin supplements contain a dose of 0.3 to 3 milligrams, Dr. Lieurance has 30 years of clinical experience and, during our conversation, shares his unorthodox but largely research-backed views on melatonin, methylene blue, and mitochondrial health.

As one of the world's leading clinical experts on melatonin and methylene blue, Dr. Lieurance reveals findings that most people have never heard, including why melatonin is an amazing adaptogen and how it even prevents the Warburg effect that powers cancer cells.

The second half of our conversation explores methylene blue, the original compound that inspired the term "magic bullet." Dr. Lieurance explains how this brilliant blue salt was discovered while searching for a malaria cure, how it increases mitochondrial function by an average of 30%, and why it acts as both a prooxidant and antioxidant.

Most fascinating is the synergy with red light therapy…methylene blue absorbs 660-nanometer photons, supports cytochrome C oxidase, and creates powerful antimicrobial effects. He shares clinical dosing protocols, debunks FDA warnings, and explains why higher doses are more effective than the micro-doses commonly recommended.

In this podcast, Dr. Lieurance and I discuss:

• His personal health journey and why he takes hundreds of milligrams of melatonin every night, while maintaining high testosterone levels, directly contradicting Andrew Huberman's warnings based on flawed rodent studies

• Melatonin studies that used up to 150,000 milligrams with zero toxicity found, yet recent claims suggest melatonin is toxic to kids, with little research to support it

• The fact that your gut produces 400 times more melatonin than the pineal gland!

• Every single cell produces its own melatonin within the mitochondria, a discovery that only emerged in the last couple years, completely reframing melatonin's importance

• The biological reason why you can take large amounts of melatonin for extended periods and stop the next day without suppression of natural production

• The connection between melatonin, hormesis, and your mitochondria

• How high-dose melatonin protects you from sun damage

• The interesting story of methylene blue, the original "magic bullet" discovered while curing malaria

• How methylene blue increases mitochondrial function by 30% on average

In this episode, Dr. Chris Masterjohn cuts through the noise with his refreshingly practical approach to nutrition for your mitochondria. He exposes supplement industry myths and explains why your mitochondria need more than just CoQ10 and alpha-lipoic acid. Plus, his insights into how your brain regulates energy metabolism will completely shift how you think about fatigue.

Whether you're dealing with chronic exhaustion or just want to optimize your energy, this conversation delivers actionable wisdom—Dr. Masterjohn even shares his favorite "superfood cocktail." Get ready to question everything you thought you knew about mitochondrial nutrition!

This episode was initially released in Sept 2023

What if curing cancer and heart disease wouldn't actually extend human lifespan by much? It sounds crazy, but this concept opens the door to my conversation with Dr. Greg Kelly, Director of Product Development at Neurohacker Collective and author of Shape Shift.

The reason is simpler than you think: most people would still die in their mid-80s from accumulated cellular damage and "dying of old age," i.e., multi-organ failure from decades of cellular aging.

Dr. Kelly brings a unique perspective, having served as a Navy officer before becoming a naturopathic physician and spending two decades in the trenches of longevity research. He shares a fascinating personal story about repaying his massive sleep debt from his military years—sleeping 12 hours a night for weeks until his chronically cold hands suddenly became warm. His insights on why catching up on sleep often makes us feel more tired will completely reframe how you think about recovery.

This conversation goes deep into cellular senescence ("zombie cells" that accumulate as we age), the gut microbiome's role in longevity, why melatonin supplements are often misused, and which nootropics actually work.

Dr. Kelly explains the "last straw" model of stress that will change how you view your health, and why chasing individual diseases instead of focusing on cellular aging is like rearranging deck chairs on the Titanic.

This episode was initially released in July 2023