Over 270,000 new cases of breast cancer are diagnosed each year in the US. And while BRCA mutations often get the most press, there are other, potentially more critical factors we can address. Today, Dr. Ruth Hobson joins us to delve into the realm of breast health, shedding light on both modifiable and non-modifiable risk factors, and sharing real-life strategies for supporting our patients.

We dive into a range of essential topics, from dietary and lifestyle influences to the ongoing debate around Hormone Replacement Therapy (HRT), and venture into the world of functional tests to evaluate hormones and metabolites crucial for comprehensive breast health. We’ll uncover the intricate connection between gut health and breast health - Did you know that breast tissue has its own microbiome?!? - and examine how inflammation, peripheral fat, and methylation impact cancer risk. Bring a pen and paper, this is a deep dive into the hormones and breast health that you won’t want to miss. ~DrKF

The epigenetic pioneer, Dr. Randy Jirtle, returns to New Frontiers to share his latest groundbreaking work. And I really do mean groundbreaking. Dr. Jirtle's work in mapping our "imprintome" is literally creating a brand new branch of scientific study that is expected to provide valuable insights and opportunities for epigenetially-targeted therapies, including nutrition and lifestyle. What I so appreciate about Dr. Jirtle's work is that it clearly demonstrates how we are not inescapably at the mercy of our genes. Instead, Dr. Jirtle views disease-associated genes as a starting point for the environment to direct its expression. Join me on this episode of New Frontiers to find out what your imprintome actually is, why it is so important, and what you can expect from this area of scientific discovery in the near future. ~DrKF

If you're a clinician and finding yourself pressed for time in your practice, you're certainly not alone. A recent survey of over 9,000 US physicians revealed that more than half are experiencing burnout. Fortunately, the field of functional medicine is rapidly evolving, bringing tools that promise to streamline and improve accessibility in our practices. Rupa Health is one such tool.

In this episode of 'New Frontiers, I’m joined by Dr. Kate Kresge, Head of Medical Education at Rupa Health. Together, we'll explore the remarkable resources offered by this advanced specialty lab testing platform. We'll also dive into the profound impact of chronic illnesses on our society, the crucial role functional labs play in providing answers that lead to lasting solutions, and how Rupa Health is at the forefront of reshaping the healthcare landscape through continuous innovation.

Don't forget to check out the show notes at www.DrKaraFitzgerald.com for all the relevant links and resources. ~DrKF

Get ready for an enlightening conversation as I welcome Dr. Izabella Wentz, renowned Thyroid Pharmacist and an accomplished author, to New Frontiers. We’ll talk about her new book and dive into the often underappreciated and enigmatic connection between adrenal dysfunction and hypothyroidism, and how extreme stress can accelerate aging and impact immunity.

Dr. Wentz provides invaluable insights into her personally crafted transformation techniques that can pave the way for enhanced mental and physical well-being, spanning dietary adjustments, lifestyle modifications, targeted supplementation, circadian rhythm optimization, and the power of a resilient mindset. We also chat about the pivotal role of community support in effectively managing adrenal imbalances. Whether you’re an experienced practitioner or someone navigating your own health journey, this conversation promises to be both riveting and profoundly enlightening. So, let’s dive right in!~DrKF

In this episode, I have the pleasure of interviewing Mark Newman, the president and founder of Precision Analytical, the company behind the revolutionary DUTCH test.

Mark is a true pioneer in the field of hormone testing, and in our conversation, we delve into the latest developments in this rapidly evolving field. We discuss how the DUTCH test has expanded to include additional markers, providing even more comprehensive insights into hormone health. During our conversation, we also address the controversy surrounding saliva testing for hormone analysis. Mark sheds light on the limitations of this method and why the DUTCH test offers a more accurate and reliable alternative.

I’m sure you’ll find this interview as fascinating as I did, and it will be super helpful for identifying the best forms of hormone testing for your patients. So, without further ado, let’s dive into this enlightening conversation with Mark Newman. ~DrKF

Harvard's award-winning Dr. Charles Serhan isn't just an expert on specialized pro-resolving lipid mediators (SPMs), he is the scientist who actually discovered them. His breakthroughs opened up a brand new field of research and clinical application with immense potential. After all, chronic, unresolved inflammation is a contributor or cause of so many conditions.

The growing body of research on the utility of SPMs continues to astound (although when you start to understand the mechanisms, it's perhaps easy to understand some of the "why") - pain, rheumatoid, osteo- and Lyme arthritis, macular degeneration, periodontal disease, uveitis, surgical recovery, and repetitive head injury, for instance, have all been shown to be potentially benefited by the ability of SPMs to promote inflammation resolution. Clinically, I consider SPMs in all conditions where unresolved inflammation is a contributing factor. Not only that, but SPMs appear to have some rather surprising additional effects including stem cell regulation, tissue regeneration, and inhibition of amyloid-beta peptide in Alzheimer's models (even restoring memory loss in mice).

I am honored to host Dr. Serhan here on New Frontiers along with his esteemed colleague, Dr. Megan Sulciner. Dr. Sulciner is a clinician-scientist and resident in the Serhan Lab whose exciting work focuses on advancing postoperative outcomes for surgical patients as well as the role of SPMs in enhancing cancer therapy and preventing cancer metastasis. I’m sure you will love this insightful, tour-de-force conversation! ~DrKF

Vascular health is fundamentally essential to longevity and health span, and that’s why I’m thrilled to be welcoming Dr. Michael Twyman to New Frontiers. Trained as an invasive cardiologist, Dr. Twyman has made the shift to a more preventative approach, moving beyond traditional cath lab results to focus on the health of the 60,000 miles of blood vessels that carry vital blood, oxygen and nutrients to every organ in the body, with hopes of reaching patients before they reach the end stages of disease.

In this episode we’ll look at endothelial glycocalyx dysfunction as the root cause of cardiovascular disease, and dive into the key roles of nitric oxide, circadian biology, and the oral microbiome on cardiovascular health. I know you’ll find this interview to be absolutely fascinating. Have a listen and leave me a comment let me know what you think. ~DrKF

I’m so happy to be here with Dr. Vincent Pedre to dig into emerging science on the microbiome. Dr. Pedre shares extensive clinical pearls from his vast experience in functional gut health in an approachable and fun way as he drills down on possible causes of the challenging gut epidemic we clinicians see in the increasing numbers of IBS patients walking through our doors.

Dr. Pedre and I discuss how microbial diversity is the holy grail for reducing the risk of chronic disease, and how the gut disruptors of our time, (including food and environmental toxins, chronic stress, our over-sterilized world and lack of time in nature) are leading to many of the health challenges of the day. We get into current science on the impact of a high-fiber vs a diet high in fermented food on microbial diversity and immune activation. And there’s more: we talk about how where we live matters when it comes to our microbiome, the health- or disease-promoting post-biotics that are created, our optimal diet, overall health and our ability to create stress resiliency. It’s a lot -- and I’m sure you’ll be fascinated by Dr. Pedre and find numerous valuable insights to support your patients. Thanks for listening, and please leave me a review wherever you hear my voice. ~DrKF

As we gain insight into microbiome impact on our health, we need accurate tests that tell us not only what and how much is there, but also which metabolites, or post-biotics created that can have downstream effects. So today I’m thrilled to welcome the brilliant Dr. Erika Ebbel Angle, PhD, biochemist, CEO, and co-founder of Ixcela, to discuss their fingerstick gut microbiome test. We’ll discuss the 11 key markers, the value of a blood sample over urine, and the impact of endurance sports and chronic stress on health markers as revealed by the test.

We also chat about my own results, how impressed I was by the insight provided – and how they clearly identified changes I could make to improve my markers. Listen and take notes -- I know I did! ~DrKF

Buckle up everybody, because this conversation is a big tour de force of where we are headed in regards to longevity and innovative technology within healthcare. I am joined by my friend, longevity investor and visionary, Sergey Young, to discuss his incredibly important mission of extending healthy lifespans of at least one billion people using technological breakthroughs AND by making longevity affordable and accessible. Sergey is a top 100 longevity leader and one of the co-creators of AGE REVERSAL XPRIZE, a global competition designed to cure aging. Today’s conversation looks at the fundamental issue of healthcare inequality, the democratization of access to healthcare, and dives into the current paradigm shift of using technology for disease prevention and reversal of biological aging. I’m sure you’ll enjoy this conversation as much as I did, and be wowed by the work of Sergey Young. ~DrKF