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In this episode of Causes or Cures, Dr. Eeks chats with Dr. Alessio Fasano about the Hygiene Hypothesis and its connection to our guts, microbiomes and chronic inflammatory diseases.
The Hygiene Hypothesis is a proposed explanation that states that improved hygiene in an industrialized world and less exposure to infectious agents ( bacteria & viruses) has led to an increase in chronic inflammatory conditions. ( This is why some supporters of the Hygiene Hypothesis will tell you to take your kids to a farm or play in the dirt.) In this episode, Dr. Fasano discusses how this hypothesis relates to a leaky gut and how our modern way of life may affect our microbiome ( bacteria that live in our gut) in a way that puts us at risk of developing a chronic inflammatory condition. He will discuss the 5 pillars that he believes need to be in place for this to happen, how probiotics and gluten relates to this, and ways we can improve leaky guts.
Dr. Fasano is a pediatric gastroenterologist and researcher. He is a professor of pediatrics at Harvard Medical School and professor of nutrition at Harvard School of Public Health. He is the director of the Center for Celiac Research and Treatment at Mass General for children and co-director of the Harvard Medical School Celiac Research Program. He's the director of the Mucosal Immunology and Biology Research Center, where he oversees over 50 researchers and staff. Dr. Fasano is credited with discovering Zonulin, a protein responsible for regulating intestinal tight junctions ( and he explains this in the podcast) and he is the author of over 300 peer-reviewed publications. He is considered a world expert on Celiac disease and is in the top 1% of scientists cited worldwide.

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