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A single ion is changing how we read the story of canine heart failure. We sit down with cardiologist Dr. Darcy Adin and internist–nephrology researcher Dr. Autumn Harris to unpack why hypochloremia—once dismissed as collateral damage from diuretics—now stands out as a powerful predictor of survival in dogs with stable congestive heart failure. The conversation moves from physiology to practice, showing how chloride levels map to renin–angiotensin activation, diuretic resistance, and risk, and how that knowledge can guide smarter, earlier interventions.

We trace the research arc: early work that spotlighted chloride as more than a bystander, data linking low chloride to advanced disease stages and higher diuretic needs, and the pivotal finding that hypochloremia predicts outcomes even after controlling for other variables. Along the way, we break down renal salt sensing at the macula densa, why chloride depletion ramps up neurohormonal stress, and how this affects real dogs with mitral valve disease and congestive heart failure. If you manage CHF cases, this is practical cardiology and nephrology in lockstep.

Most importantly, we translate the science into steps you can use tomorrow. We talk thresholds and trend-watching, ensuring chloride is on every chemistry panel, covering RAS inhibition, adjusting diuretic strategies to spare chloride, and when to consider chloride supplementation. We also preview active trials targeting chloride to improve diuretic responsiveness, cut hospital time, and lift quality of life. Owners get a clear takeaway too: lab values are not just numbers; they’re signals that help personalize care and extend good days.

If you care for dogs with heart failure—or love one at home—this deep dive reframes a humble electrolyte as a crucial guide. Listen, share with your team, and help push the field forward. Enjoyed the conversation? Subscribe, leave a review, and tell us how you monitor chloride in your CHF workflow.

JAVMA article: https://doi.org/10.2460/javma.25.08.0526

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