Humans crave certainty — in science and politics, in our lives and our leaders, in our decisions and our futures. We find comfort in knowing the facts, and we fear the murky unknown. In the age of information, we've grown increasingly unnerved by uncertainty and do everything we can to mitigate that anxiety. We do research online, play out scenarios in our heads, make plans A, B, and C — imagining that if we can just prepare well enough, everything will be OK. But in her latest book, "Uncertain: The Wisdom and Wonder of Being Unsure," author and journalist Maggie Jackson makes the case for an opposite way of being — embracing the unknown as an invitation to pause, an opportunity for growth and innovation. On this episode, we talk with Jackson about her book, and what science teaches us about living — and even thriving — amid uncertainty. We also hear stories about one reporter's quest to make a life-changing decision while filled with doubt, and how saying "yes" to the unknown changed an introvert's life.

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We're in a major technological revolution where artificial intelligence, gaming, and virtual reality allow us to create and enter totally new spaces and have new experiences there.In these virtual worlds, we can reinvent ourselves, connect with people around the world, or take on new challenges and adventures. But as these worlds grow bigger, more intense, and consuming, they're also raising questions about what this new future will look like.We all know things are going to be different — but how? Will we soon have entirely new and far more fabulous lives in the virtual realm? Or will things feel surprisingly similar and mundane? How will a computer-generated life intersect with real life?On this episode: virtual worlds, virtual lives, and how they're changing our reality. We hear stories about Second Life — and the surprising political power structures that have emerged there; what happens when romantic relationships with AI go bad; and how increasingly realistic gaming worlds have led to the emerging discipline of archaeogaming.

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We all know that exercise is good for us — for both our bodies and our minds — but motivating yourself to hit the gym, take a run, or even go for a walk sometimes feels like the hardest thing in the world. There are constant rebuttals that arise in our minds: We're too busy. We're too tired. We need a break — we'll start next week. At the same time, we're bombarded by messages from people who are all about fitness — influencers with seemingly perfect bodies and a healthy glow, who convince us that we too can get into shape. It's a habit that many of us try to cultivate — yet often seem to hit a wall. On this episode, we look at the science of fitness, the evolution of cultural messages surrounding exercise, and how we can overcome inertia to start fitting it into our lives. We'll hear about how exercise affects our mood and overall health, different approaches to getting in shape, the real-life struggle of becoming an Instagram fitness influencer, and one couch potato's reluctant journey to getting active.

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It's the goosebumps you get at the crescendo of your favorite song; the stupefying wonder that comes with witnessing a birth or a death; the astonishing mystery we feel when gazing at the vast night sky. This is awe — a complex, often overwhelming emotion that can elicit everything from pleasure and connectedness to a crawling sense of uncertainty. Moments of awe can create unforgettable memories — and they can have a lasting impact on our minds and the way we interact with others. One of the leading scientists studying awe is Dacher Keltner, a University of California, Berkeley psychologist, who's dedicated the past 15 years to investigating the origins and effects of this emotion. On this episode, we talk with Keltner about his new book "Awe: The New Science of Everyday Wonder and How it Can Transform Your Life." He discusses his own, very personal experience of awe amid profound grief, the ability of awe to transform our experience of the world, and how we can cultivate awe on a daily basis. We also hear from listeners about their experiences of awe, and listen back to a story about how voyages to space change the way astronauts perceive life, their relationships, and Earth as a whole.

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We think of life and death as clear cut — you're alive or you're not; your heart's beating or it isn't; your brain functions or it doesn't. But when you look a bit deeper, both on a biological level, and in terms of people's experiences, the border where life ends and death begins starts to look less firm, leading to questions about what comes next.

On this episode, we explore the blurred line between life and death. We hear about near-death experiences, and what researchers say about the difference between our brains and our consciousness; we discuss a pioneering approach to collecting organs that is raising questions about the definition of death; and we'll explore why some people experience sudden bursts of lucidity before death. Also, a story about a controversial contest to prove the existence of life after death.

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Lots of things can get in the way of taking care of your health, catching medical issues early on, and getting treatment. Navigating insurance woes, trouble scheduling appointments, big medical bills — but also broader issues like lack of access, distrust in the medical system, and language barriers can stand in the way of patient care. On this episode, we'll take a look at barriers to health care — especially for America's most vulnerable populations — and explore potential solutions. We hear stories about a new initiative to screen for colorectal cancer, how AI is helping to bridge language divides, and a recent push to institute screenings for the forgotten sense.

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What comes to mind when you think of the ocean? Maybe a day at the beach — swimming in the waves, snorkeling through coral reefs, fishing, surfing, and sunsets that kiss the blue horizon. But Earth's oceans are more than all of that; they're our planet's defining feature, its largest ecosystem, the original source of all life, and, according to physicist and oceanographer Helen Czerski, the engine that powers our planet. On this episode, we talk with Czerski about her new book, "The Blue Machine: How the Ocean Works," and why she says the ocean is critical not only to our climate system, but to the big and small processes that sustain and shape life on Earth. She also helps us understand the many intricacies of the sea, from the reasons why it's salty to how the Earth's rotation affects its currents. We also hear stories about efforts to restore coral reefs using sound and find out why scientists are looking for climate time capsules at the bottom of the ocean.

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For decades, the idea that you could attack genetic illnesses right at the root — that you could modify people's genes to treat or cure disease — sounded like science fiction. But in recent years, several new gene therapy treatments have been FDA approved, and many others are showing promise in clinical trials. On this episode, we take a look at what's new with gene therapy, what's on the horizon, and the challenges standing in the way. We hear stories about making these treatments more affordable by changing the manufacturing process, what happened when one family tried to enroll their son in a clinical trial under a looming deadline, and one man's DIY approach to curing his own condition. We also chat with a pioneer in the field of gene therapy about sticking with her research during a time when funding dried up and interest in the field had faded.

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What we make for dinner, grab as a snack, or have for breakfast changes all the time — and there are some major forces at play: consumer tastes and marketing, but also climate change, global supply chains, nutrition science, health concerns, and social media influencers. On this episode, we'll look at what we eat and why.

We'll find out how lima beans are getting a makeover, and why seed oils ended up becoming a lightning rod in nutrition debates. We'll also taste a futuristic green with self-proclaimed superpowers, meet one physician who's trying to convince people to eat more organ meats, and another who says to stay away from anything marketed as health food.

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Sugary cereals for breakfast, a protein bar as a snack, a microwave lasagna for lunch, and a frozen pizza for dinner sounds like a teenager's dream diet, but these are the types of foods physician Chris van Tulleken ate for four weeks. During this time, he got 80 percent of his daily calories from ultra-processed foods, to see how it would impact his health and mood. He writes about this experience, and his extensive research on these products in his new book, "Ultra-Processed People: The Science Behind Food That Isn't Food." Host Maiken Scott talks to Van Tulleken about the link to obesity and disease, and why he says we should probably avoid anything that's marketed as a health food.

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