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Originally aired May 22, 2015. Amol and Janice want you to understand the following: 1. Several RCTs and observational studies suggest that Transcatheter Aortic Valve Replacement reduces mortality and improves symptoms in frail, elderly patients. 2. A historical analysis demonstrates that the sugar industry had heavy influence in setting national dental research priorities in the 1970s, which ...

The post Summer Replay 3: Transcatheter Aortic Valve Replacements and Sugar Industry Influence on Research Priorities appeared first on Healthy Debate.

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Amol and Nathan want you to understand the following: 1. A large randomized evaulation of a quality improvement intervention demonstrated a modest but significant reduction in rates of cesarean-section in Quebec. 2. A large double-blind randomized-controlled-trial of over 1100 patients showed that pentoxifylline is not beneficial in the treatment of alcoholic hepatitis and prednisolone may have mild ...

The post Summer Replay 2: Reducing c-sections and prednisolone vs. pentoxifylline for alcoholic hepatitis appeared first on Healthy Debate.

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Aired April 23: Empiric antibiotic choices for community acquired pnuemonia and clindamycin versus trimethoprim-sulfamethoxazole for skin and soft tissue infections. Fahad and Amol want you to understand the following: 1. A large, high quality RCT showed that there was no significant difference between an empiric treatment strategy of beta-lactam vs beta-lactam plus macrolide vs respiratory fluoroquinolone for ...

The post Summer Replay: Community Acquired Pneumonia and Skin Infections appeared first on Healthy Debate.

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Fahad and Amol want you to recognize that: 1. Idarucizumab as an agent that specifically reverses the hemostatic effects of dabigatran.  2. A post-hoc analysis of the ROCKET-AF study showed that digoxin is associated with increased mortality in patients with atrial fibrillation. The papers Idaracizumab for Dabigatran reversal. Digoxin use and mortality in ROCKET-AF. Good stuff http://www.smacc.net.au/about-us/welcome/ http://emupdates.com/wp-content/uploads/2015/06/Strayer-Opioid-Misuse-SMACC-Slideset.pdf ...

The post Season Finale: Dabigatran Reversal and Digoxin Mortality appeared first on Healthy Debate.

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Amol wants you to: 1. Consider how the evidence helps us decide whether to prescribe a patient warfarin or a novel oral anticoagulant for stroke prevention in atrial fibrillation. Continuing Medical Education Internists can receive 0.5 hours of Continuing Medical Education credit for each podcast they listen to through the Canadian Society of Internal Medicine (MOC Category 1) ...

The post Flying Solo: Warfarin vs. New Oral Anticoagulants, what does the evidence say? appeared first on Healthy Debate.

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Originally Published December 5, 2014: Travis and Amol want you to recognize that: 1. Recognize whole exome sequencing is an important new method of identifying genetic mutations associated with disease. 2. Understand that the 4-year follow-up of the PROTECT AF study showed that left atrial appendage closure devices may be superior to warfarin in preventing strokes in patients ...

The post Repeat: Value Judgments – Whole exome sequencing and left atrial appendage closure devices appeared first on Healthy Debate.

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Amol and Reena want you to understand the following: 1. When added to moderate dose statin, the IMPROVE-IT randomized trial showed that ezetimibe improved clinical outcomes in patients after acute coronary syndrome. 2. A network meta-analysis showed that no blood pressure lowering therapy improved mortality in patients with diabetes and chronic kidney disease. The combination of ACE-inhibitors and ...

The post Debatable Landmarks: Ezetimibe and clinical outcomes, BP lowering in diabetes and kidney disease appeared first on Healthy Debate.

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Amol and Nathan want you to understand the following: 1. A short duration (4 days) of antibiotics for intra-abdominal sepsis was equivalent to a longer duration (approx. 8 days) of antibiotics for intra-abdominal sepsis after an appropriate source control procedure. 2. A population-based cohort study of elderly patients showed that lipid lowering therapy for primary prevention was ...

The post On Our Soapbox: Antibiotics in intraabdominal sepsis and lipid therapy in the elderly appeared first on Healthy Debate.

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Amol and Fahad want you to understand the following: 1. There are dramatic hospital-level variations in the care of extremely pre-term infants. 2. A randomized trial showed that an electronic alert to identify hospital patients with acute kidney injury was not effective in improving patient outcomes. Continuing Medical Education Internists can receive 0.5 hours of Continuing Medical ...

The post Lifelong Learning: Variations in Care of Pre-term Infants and Electronic Alerts for Acute Kidney Injury appeared first on Healthy Debate.

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Amol and Janice want you to understand the following: 1. Several RCTs and observational studies suggest that Transcatheter Aortic Valve Replacement reduces mortality and improves symptoms in frail, elderly patients. 2. A historical analysis demonstrates that the sugar industry had heavy influence in setting national dental research priorities in the 1970s, which is relevant for industry relations ...

The post The Sweet Truth: Transcatheter Aortic Valve Replacements and Sugar Industry Influence on Research Priorities appeared first on Healthy Debate.