The Stem Cell Podcast

The Stem Cell Podcast

By The Stem Cell PodcastScienceNatural Sciences
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The Stem Cell Podcast episodes

  • Ep. 57: “Curiosity” Featuring Duane Fernandez
    Guest:
    Writer, director and photographer Duane Fernandez talks about how curiosity drives him and his work. We talk to Duane on his experience with helping people from all walks of life and business experience their true potential and how this can apply to science.
    Resources and Links
    The Woman Who Can Smell Parkinson's Disease – According to this article, a woman from Perth named Joy Milne can detect people with Parkinson’s through a telltale odor.
    Neurons from Glia In Vivo – Scientists present new recipes for directly converting glial cells to neurons in mouse brains.
    Exclusive Video: First "Glowing" Sea Turtle Found – Scientists diving near the Solomon Islands made an illuminating discovery: the first biofluorescent reptile ever recorded.
    Japanese Scientist Haruko Obokata Stripped of Doctorate over Stem Cell Scandal – Waseda University revoked a doctoral degree awarded to a young researcher embroiled in a scandal that has rocked the scientific establishment.
    Fighting Citrus Greening with Vibrating Orange Groves – According to this article, hijacking the mating signals of Asian citrus psyllids may help provide an environmentally friendly system for preventing citrus greening - a disease that has cost the Florida citrus industry billions of dollars in recent years.
    Neurons Reprogrammed in Animals – Harvard Stem Cell Institute researchers have now shown that the networks of communication among reprogrammed neurons and their neighbors can also be changed, or “rewired.”
    A Cell Therapy Untested in Humans Saves a Baby with Cancer – This article reveals that cancer doctors have been electrified by a new approach that involves genetically altering patients’ T cells, the soldiers of the immune system, so that they can better attack cancers.
    Ovarian Cancer Drug Promising for Prostate Tumors – Olaparib, a drug designed to fight inherited ovarian cancers in women, appeared to help some men with advanced prostate cancer done in a small trial.
    Insulin Plays Very Strong Role in Dopamine Release, Significantly Influences This Important Choice – The more insulin there is in the brain, the more dopamine will be released, but new research indicates that this dopamine regulation might actually affect what we choose to eat.
    The Effect of Oxytocin Nasal Spray on Social Interaction Deficits Observed in Young Children with Autism: A Randomized Clinical Crossover Trial – This article shows that the synthetic hormone oxytocin nasal spray may provide a potential treatment to improve core social and behavioral difficulties in autism, but its efficacy has yet to be evaluated in young children who potentially may benefit to a greater extent.
    Small Molecules Efficiently Reprogram Human Astroglial Cells into Functional Neurons – Researchers demonstrate that sequential exposure of human astrocytes to a cocktail of nine small molecules that inhibit glial but activate neuronal signaling pathways can successfully reprogram astrocytes into neurons in 8-10 days.
    3D Technology, Stem Cells Used to Aid Skull Bone Regrowth – A team of West Australian researchers will help patients needing cranial reconstructions to regrow parts of their own skulls as part of a new procedure using stem cells and advanced 3D printing technology.
    New Studies Question the Treatment of Female Infertility with Stem Cells – Professor Kui Liu from University of Gothenburg led a study, together with Professor Outi Hovatta of Karolinska Institutet, assert that the procedure of isolating stem cells is aspecific and also that the stem cells have not been capable of forming eggs.
    Co-Transplantation of Autologous Bone Marrow Mesenchymal Stem Cells and Schwann Cells through Cerebral Spinal Fluid for the Treatment of Patients with Chronic Spinal Cord Injury: Safety and Possible Outcome – This article discusses the procedure of how some researchers assess the safety and feasibility of bone marrow mesenchymal stem cell and Schwann cell co-injection through cerebral spinal fluid for the treatment of patients with chronic spinal cord injury.
    Gene Found that Regulates Stem Cell Number Production – A scientific team from the University of Southern California and the University of California, San Diego have described an important gene, Prkci, that maintains a critical balance between producing too many and too few stem cells.
    In Vitro Optimization of Nanoparticle-Cell Labeling Protocols for In Vivo Cell Tracking Applications – Researchers suggest that while heeding the slight variations within cell lines, modifying the loading time and concentration of gold nanoparticles, can promote cell visibility in various nanoparticle-dependent in vivo cell tracking and imaging applications.
    Differential Responses to Lithium in Hyperexcitable Neurons from Patients with Bipolar Disorder – Scientists developed an induced pluripotent stem-cell (iPSC) model for human bipolar disorder and investigated the cellular phenotypes of hippocampal dentate gyrus-like neurons derived from iPSCs of patients with bipolar disorder.
    A Comparison of Genetically Matched Cell Lines Reveals the Equivalence of Human iPSCs and ESCs – Researchers found that human induced pluripotent stem cells (iPSCs) and human embryonic stem cells (ESCs) are molecularly and functionally equivalent and cannot be distinguished by a consistent gene expression signature.
    Photo Reference: Courtesy of Duane Fernandez
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    1 hr 10 min
  • Ep. 56: “Glia” Featuring Dr. Steven Goldman
    Guest:
    Dr. Steven Goldman from the University of Rochester talks about glial cells and his work using neural stem cells to model and fix diseases, like multiple sclerosis.
    Resources and Links
    Can a Cancer Drug Reverse Parkinson's Disease and Dementia? – A drug that's already approved for treating leukemia appears to dramatically reduce symptoms in people who have Parkinson's disease with dementia, or a related condition called Lewy body dementia.
    Study Shows Antioxidant Use May Promote Spread of Cancer – Scientists at the Children’s Research Institute at The University of Texas Southwestern have made a discovery that suggests cancer cells benefit more from antioxidants than normal cells, raising concerns about the use of dietary antioxidants by patients with cancer.
    Sitting for Long Periods Is No Worse for Your Health than Standing, Study Claims – This article reveals that prolonged sitting doesn’t appear to be killing you any faster than standing.
    Does Fungus Cause Alzheimer's? – In this article, researchers discover traces of fungus in the brains of Alzheimer's sufferers.
    Schizophrenia Symptoms Linked to Features of Brain's Anatomy? – This article describes how Washington University psychiatrist C. Robert Cloninger, MD, PhD, and fellow researchers have matched certain behavioral symptoms of schizophrenia to features of the brain's anatomy using advanced brain imaging.
    Can Diamonds Detect Cancer? – A new study out of Australia found that synthetic versions of diamonds to be effective at detecting early-stage cancerous tumors through magnetic resonance imaging.
    Armed Malaria Protein Found to Kill Cancer Cells – A new type of cancer therapy based on seemingly unrelated elements of malaria and cancer is showing promise for development.
    Ebola Found in the Semen of Some Men Nine Months Later – This article reveals that some men still have fragments of Ebola virus in their semen nine months after first showing symptoms of the virus.
    Larger Brains Do Not Lead to High IQs – This article shows that brain volume plays only a minor role in explaining IQ test performance in humans, but rather brain structure and integrity appear to be more important as a biological foundation of IQ.
    AIDS Pioneer Finally Brings AIDS Vaccine to Clinic – Robert Gallo’s team has been developing a vaccine with an unusual method of protection for 15 years and is now launching the first clinical trial of it in collaboration with Profectus BioSciences, a biotech that spun off from Institute of Human Virology.
    Newly Unraveled Dynamic Structure of DNA Could Pave Way for Better Medicines – This article reports that an improved understanding of the appearance of the DNA – shown in research to have a dynamic, constantly wiggling and morphing nature – is believed to help scientists in producing new antibiotics, more effective chemotherapies and better drugs.
    First 'In Womb' Stem Cell Trial to Begin – This article announced the first clinical trial injecting fetal stem cells into babies that are still in the womb.
    Scientists Produce Beef from Cow’s Stem Cells: Lab-Grown Burgers Could Be on the Menu by 2020 – Professor Mark Post who created the lab-grown burger made from stem cells in his lab facility in Maastricht, The Netherlands is developing the technology for mass production expressed confidence in having the novel product on the market in five years.
    Scottish Researchers Are 3D Printing Extremely Delicate Stem Cells – The team at Heriot-Watt led by Dr. Will Shu, at the University’s School of Engineering and Physical Sciences, have the distinction of being the first group to 3D print with stem cells, using a valve-based technique.
    Single Cell RNA-Sequencing of Pluripotent States Unlocks Modular Transcriptional Variation – Researchers find that the cellular transcriptomes of cells grown in three different conditions: serum, 2i, and the alternative ground state a2i, are distinct, with 2i being the most similar to blastocyst cells and including a subpopulation resembling the two-cell embryo state.
    Neural Stem Cells Rescue Cognitive and Motor Dysfunction in a Transgenic Model of Dementia with Lewy Bodies through a BDNF-Dependent Mechanism – This article describes how striatal transplantation of neural stem cells into aged α-synuclein transgenic mice significantly improves performance in multiple cognitive and motor domains.
    Vascular Platform to Define Hematopoietic Stem Cell Factors and Enhance Regenerative Hematopoiesis – Researchers demonstrate that AKT1-activated bone marrow endothelial cells (BMEC-Akt1) have a unique transcription factor/cytokine profile that supports functional hematopoietic stem cells in lieu of complex serum and cytokine supplementation and the transplantation of BMEC-Akt1 cells enhanced regenerative hematopoiesis following myeloablative irradiation.
    Crestospheres: Long-Term Maintenance of Multipotent, Premigratory Neural Crest Stem Cells – This article shows the conditions that enable maintenance of neuroepithelial “crestospheres” that self-renew and retain multipotency for weeks.
    Model of Fibrolamellar Hepatocellular Carcinomas Reveals Striking Enrichment in Cancer Stem Cells – Researchers present a transplantable tumor line, maintained in immune-compromised mice, and validate it as a bona fide model of human fibrolamellar hepatocellular carcinomas by multiple methods.
    Photo Reference: Courtesy of Dr. Steven Goldman
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    1 hr 15 min
  • Ep. 55: Biomaterials and Stem Cells Featuring Dr. David Mooney
    Guest:
    Dr. David Mooney, Professor of Bioengineering at the Harvard School of Engineering and Applied Sciences discusses his work using biomaterials to help stem cells more efficiently integrate after transplantation.
    Resources and Links
    Gene-Editing Record Smashed in Pigs – Researchers modify more than 60 genes using CRISPR/Cas9 gene-editing technology in effort to enable organ transplants into humans.
    NASA Discovers Evidence for Liquid Water on Mars – NASA scientists have found compelling evidence that liquid water exists on Mars based on the “recurring slope lineae,” patches of precipitated salt that appear to dribble down Mars’ steep slopes like tears rolling gently down a cheek.
    Stem Cell Fraud: A 60 Minutes Investigation – Scott Pelley confronts one disgraced doctor offering false hope to a family with a disabled child using unproven stem cell treatment.
    Photo Reference: Courtesy of Dr. David Mooney
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    1 hr 9 min
  • Ep. 54: Stem Cell Lineage Tracing Featuring Dr. Andrew Cohen
    Guest:
    Dr. Andrew Cohen, Associate Professor at Drexel University, discusses his work on creating new software and programs to track stem cell lineages using time lapse video data.
    Resources and Links
    Antidepressants plus Blood-Thinners Slow Down Brain Cancer – Ecole Polytechnique Fédérale de Lausanne scientists found that combining antidepressants with anticoagulants slows down brain tumors in mice.
    Seasonal Body Clocks Are Controlled By 'Calendar Cells': Scientists Identify Proteins that Determine When Mammals Mate – According to this article, experts found that “calendar cells” in a structure called the 'pars tuberalis' respond according to how much daylight there is and can change dramatically over the year, driving the seasonal reproductive cycle.
    Wine's Darkest Secret Revealed - It's All in the Fungi – This article reveals that a type of yeast called Saccharomyces cerevisiae, makes a "small but significant" contribution to a wine's flavor and taste.
    Edges of Human Embryonic Stem Cell Colonies Display Distinct Mechanical Properties and Differentiation Potential – This article describes the results found after the live imaging of the differentiation process of human embryonic stem cells, and reveals that cells on the outer edge of the undifferentiated colony begin to differentiate first and remain on the perimeter of the colony to eventually form a band of differentiation.
    Orthostatic Hypotension May Indicate Neurological Disease – According to this article, orthostatic hypotension may be an early warning sign of a serious neurological disease and may be associated with an increased risk of premature death.
    Why People in 'Tall' Nations Are More Likely to Be Slim – Researchers from Australia looked at nearly 9,500 people in 14 European countries and found a strong connection between genes that boost height and those associated with lower amounts of body fat.
    Salsalate Drug Offers New Hope for Treating Alzheimer's Disease and FTD – Scientists from the Gladstone Institutes discovered that salsalate, a drug used to treat rheumatoid arthritis, effectively reversed tau-related dysfunction in an animal model of frontotemporal dementia (FTD).
    A Barrier against Brain Stem Cell Aging – Scientists from the University of Zurich identified a diffusion barrier that regulates the sorting of damaged proteins during cell division.
    New Study Finds Brain Disease in 95% of Deceased NFL Players – Researchers found evidence of brain disease in 95% of brains tested belongs to former NFL players with the repeated minor head trauma as the biggest risk to neurological health for footballers.
    Pinpointing Punishment – This study describes a new study co-authored by Joshua Buckholtz, an Assistant Professor of Psychology, René Marois, professor and chair of psychology at Vanderbilt and colleagues, explaining how a brain region called the dorsolateral prefrontal cortex coordinates third party punishment decisions of the type made by judges and juries.
    UK Scientists Apply for License to Edit Genes in Human Embryos – Scientists from London’s Francis Crick Institute have asked for permission to edit the genomes of human embryos use CRISPR/Cas9 technology — a request that could lead to the world’s first approval of such research by a national regulatory body.
    New Technique Lets Scientists Better See, Study Interface Where Two Cells Touch – University of Buffalo researchers and their colleagues at other institutions conducted a study to better understand myelin and the fatty insulator that enables communication between nerve cells. They studied how damage to myelin occurs, and how that damage may be repaired.
    Sonogenetics Is a Non-Invasive Approach to Activating Neurons in Caenorhabditis elegans – Researchers demonstrate the use of low-pressure ultrasound as a non-invasive trigger to activate specific ultrasonically sensitized neurons in the nematode, Caenorhabditis elegans.
    Stem Cell Manufacturing Now Ready – This article announces the availability of master cell banks for induced pluripotent stem cells, hoping for U.S. Food and Drug Administration’s approval on its manufacturing process.
    cGMP-Manufactured Human Induced Pluripotent Stem Cells Are Available for Pre-Clinical and Clinical Applications – In this article, researchers develop a process for the manufacturing of induced pluripotent stem cells master cell banks under current good manufacturing practice (cGMPs) and announce the availability of such banks.
    SD Science Calendar: Nobels, Stem Cells and Robots – This article shows the calendar of events starting with the future of digital mobile health, Nobel prize week with predictions, stem cell meeting on the Mesa, and contextual robotics.
    Failed Replications Put STAP Stem-Cell Claims to Rest – This article provides an account of the history of stimulus-triggered acquisition of pluripotency (STAP) stem cells and how multiple labs conclude that the seemingly miraculous results originated from contamination with ordinary stem cells, putting the controversy to rest.
    Vatican to Host Conference on Stem Cells, Other Regenerative Medicine – The Third International Conference on the Progress of Regenerative Medicine and Its Cultural Impact will be held at the Vatican from April 28 to 30, 2016 with the goal of engaging in discussions about the potential for adult stem cells, and other ethical cellular therapies, to treat cancer, diabetes, and other debilitating medical conditions and diseases.
    Hallmarks of Pluripotency – Researchers describe the functional and molecular hallmarks of pluripotent stem cells, propose a checklist for their evaluation, and illustrate how forensic genomics can validate their provenance.
    Cpf1 Is a Single RNA-Guided Endonuclease of a Class 2 CRISPR-Cas System – This article reports how the researchers do the characterization of Cpf1, a putative class 2 CRISPR effector, demonstrating that Cpf1 mediates robust DNA interference with features distinct from Cas9.
    Scientists Discover New System for Human Genome Editing with Potential to Increase Power and Precision of Genome Engineering – A team, including the scientist who first harnessed the revolutionary CRISPR-Cas9 system for mammalian genome editing, has now identified a different CRISPR system with the potential for even simpler and more precise genome engineering.
    Deep Imaging of Bone Marrow Shows Non-Dividing Stem Cells Are Mainly Perisinusoidal – Researchers use a green fluorescent protein (GFP) knock-in for the gene Ctnnal1 in mice (α-catulinGFP), and discover that α-catulinGFP is expressed by only 0.02% of bone marrow hematopoietic cells, including almost all hematopoietic stem cells.
    Hematopoietic Differentiation Is Required for Initiation of Acute Myeloid Leukemia – This article shows that myeloid differentiation to granulocyte macrophage progenitors is required for leukemia stem cell formation and acute myeloid leukemia initiation.
    Generation of Self-Renewing Hepatoblasts From Human Embryonic Stem Cells by Chemical Approaches – This article describes how human embryonic stem cell-derived hepatoblasts can be captured and stably maintained using conditions previously established for mouse hepatoblast self-renewal, which includes basal media supplemented with insulin, transferrin, sodium selenite, epidermal growth factor, glycogen synthase kinase 3 inhibitor, transforming growth factor β receptor inhibitor, lysophosphatidic acid, and sphingosine 1-phosphate.
    Photo Reference: Courtesy of Dr. Andrew Cohen
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    1 hr 14 min
  • Ep. 53: Automated iPS Cells Featuring Dr. Scott Noggle
    Guest:
    Dr. Scott Noggle, VP of Stem Cell Research at The New York Stem Cell Foundation discusses his automated system for making iPS cells. Dr. Noggle applies new advances in pluripotent stem cell biology and cell reprogramming to the creation of human models of neurodegenerative diseases, such as Alzheimer’s disease and Parkinson’s disease to discover new disease targets.
    1 hr 6 min
  • Ep. 51: Stem Cell Theranostics Featuring Dr. Chris Armstrong
    Guest:
    Dr. Chris Armstrong, CEO of Stem Cell Theranostics, joins the hosts to discuss his company and how they are using iPSCs to model cardiovascular disease.
    Resources and Links
    Elusive Liver Stem Cell Identified in Mice by Researchers – Researchers at the Stanford University School of Medicine identified a cell type in the liver of mice that can both self-renew and make new liver cells.
    Can Crime Scene Compound Stop Malaria? – Luminol, the glowing compound detectives spray at crime scenes to find trace amounts of blood, may one day be used to kill the malaria parasite.
    Anti-Smoking Bacteria Found to Eat Nicotine – Scientists discovered anti-smoking bacteria called Pseudomas putida that eat nicotine before it reaches the brain.
    How To Reach 'Extreme Old Age': Scientists Reveal the Secret of Living to 100 Years Old – There is a good chance centenarians and super-centenarians - those who live to 105 and longer - will pass on their 'long life' genes on to their children.
    Non-Magnetic Metals Turned Magnetic in Groundbreaking Research – A team of scientists led by the University of Leeds has been able to turn the non-magnetic materials manganese and copper magnetic.
    Study Offers First Genetic Analysis of People with Extremely High Intelligence – The first ever genetic analysis of people with extremely high intelligence has revealed small but important genetic differences between some of the brightest people in the United States and the general population.
    3D Brain Map Reveals Connections Between Cells in Nano-Scale – Scientists have created an unprecedented high-resolution map of the brain that reveals structures as small as those found in individual nerve cells.
    Stem Cells Help Researchers Determine Toxicity of Pollution – The effects of BPA on mouse stem cells could be detected and measured in lab tests by researchers.
    MicroRNA-153 Regulates the Acquisition of Gliogenic Competence by Neural Stem Cells – This article shows that miR-mediated fine control of nuclear factor I A/B expression is important in the molecular networks that regulate the acquisition of gliogenic competence by neural stem/progenitor cells in the developing CNS.
    Activating Endogenous Neural Precursor Cells Using Metformin Leads to Neural Repair and Functional Recovery in a Model of Childhood Brain Injury – Metformin activates endogenous neural precursor cells in the neonatal brain.
    A Quantitative Proteomic Analysis of Hemogenic Endothelium Reveals Differential Regulation of Hematopoiesis by SOX17 – This article states that proteomics accurately identifies regulatory proteins in hematopoietic progenitors.
    Genome Editing. The Mutagenic Chain Reaction: A Method For Converting Heterozygous To Homozygous Mutations – In this article, researchers developed a method called the mutagenic chain reaction, which is based on the CRISPR/Cas9 genome-editing system for generating autocatalytic mutations, to produce homozygous loss-of-function mutations.
    Caution Urged over Editing DNA in Wildlife (Intentionally Or Not) – This article discusses the effects of rapid alteration of gene pools which could fight disease but can harm ecosystems.
    Automated, High-Throughput Derivation, Characterization And Differentiation of Induced Pluripotent Stem Cells – Researchers demonstrate that automated reprogramming and the pooled selection of polyclonal pluripotent cells results in high-quality, stable induced pluripotent stem cells.
    Prediction Of Drug-Induced Nephrotoxicity and Injury Mechanisms with Human Induced Pluripotent Stem Cell-Derived Cells and Machine Learning Methods – This article describes how the researchers developed a rapid 1-step protocol for the differentiation of human induced pluripotent stem cells into proximal tubular-like cells.
    Photo Reference: Courtesy of Dr. Chris Armstrong
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    1 hr 5 min
  • Ep. 50: Global Perspective Featuring George Daley of the Harvard Stem Cell Institute
    Guest:
    For this episode, we bring on internationally recognized stem cell pioneer Dr. George Daley from Children’s Hospital Boston and the Harvard Stem Cell Institute to discuss all things stem cells.
    Resources and Links
    New Ebola Vaccine Has ‘100 Percent’ Effectiveness in Early Results – Researchers announced promising results of a new vaccine’s trial called Ebola ça Suffit — French for “Ebola that’s enough” funded by World Health Organization, in Guinea, one of several countries affected by a historic outbreak in West Africa.
    Synthetic Ribosome Can Keep Bacteria Alive – According to this article, scientists have engineered a tethered ribosome that works nearly as well as the real thing—an organelle that produces all the proteins and enzymes within the cell.
    Anxiety and Depression Caused By Stress Linked to Gut Bacteria Living in Intestines, Scientists Find – Anxious and depressive behavior brought on by exposure to stress in early life appears only to be triggered if microbes are present in the gut.
    Scientists Have Discovered the Taste of Fat and Say It Could Hold the Key to Tackling Obesity – Scientists describe the taste of fat as a unique and unpleasant taste called oleogustus, and suggest that its identification could lead to new ways of fighting obesity and heart disease, and to the creation of improved fat replacements.
    Study Shows Glitazone Antidiabetic Drug May Reduce Risk of Parkinson’s Disease – Researchers found that diabetes patients taking glitazone antidiabetes drugs (either rosiglitazone or pioglitazone) had a 28% lower incidence of Parkinson’s disease than people taking other treatments for diabetes who had never taken glitazones.
    Long-term Memories Are Maintained by Prion-like Proteins – Research from Eric Kandel’s lab at Columbia University Medical Center reveals that different prions are critical for the long-term storage of memories.
    Astronomers Spot Black Hole So big, It Defies Current Theories of Galaxy Evolution – This article describes the discovery of a galaxy called CID-947 with a black hole that makes up 10% of its mass has left scientists dumbfounded, possibly overturning current theories of how galaxies evolve.
    Physicists Confirm Existence of Rare Pentaquarks – Professors Sheldon Stone and Tomasz Skwarnicki, doctoral student Nathan Jurik and former University research associate Liming Zhang are on the team that has confirmed the existence of two rare pentaquark states.
    Should Aborted Foetuses Be Used for Stem Cell Research? –Recent incident where US company Planned Parenthood was found to be offering foetal tissue to buyers without the parents’ knowledge has raised serious ethical questions around the use of foetuses in stem cell research.
    Four Stem-Cell Stocks With Promise – Reni Benjamin, a biotech analyst at Raymond James Financial shared four stem cell stocks that has upside potential in the second half of the year.
    From Dish to Bedside: Lessons Learned While Translating Findings from a Stem Cell Model of Disease to a Clinical Trial – Scientists share lessons while taking a discovery made using iPSCs into a clinical trial.
    Scientists Create Functional Liver Cells from Stem Cells – Scientists from the Hebrew University of Jerusalem's Alexander Grass Center for Bioengineering report that they produced large amounts of functional liver cells from human embryonic and genetic engineered stem cells.
    Researchers Create Model of Early Human Heart Development from Stem Cells – UC Berkeley researchers, in collaboration with scientists at the Gladstone Institutes, have developed a template for growing beating cardiac tissue from stem cells, creating a system that could serve as a model for early heart development and as a drug-screening tool to make pregnancies safer.
    Stem Cells Could Treat Mitochondrial Disease – Researchers generated human stem cells in the lab, repaired common mitochondrial defects, and reported they were able to rescue cell function.
    Single-Cell Transcriptomics Reveals a Population of Dormant Neural Stem Cells that Become Activated upon Brain Injury – This article unveils general principles underlying neural stem cell activation and lineage priming and opens potential avenues for regenerative medicine in the brain.
    Generation of Vascular Endothelial and Smooth Muscle Cells from Human Pluripotent Stem Cells – Researchers report the rapid and efficient differentiation of human pluripotent stem cells into vascular endothelial and smooth muscle cells.
    Functional Correction of Large Factor VIII Gene Chromosomal Inversions in Hemophilia a Patient-Derived iPSCs Using CRISPR-Cas9 – CRISPR-Cas9 and targeted sgRNAs can revert large inversions in hemophilia A iPSCs.
    Robust In Vitro Induction of Human Germ Cell Fate from Pluripotent Stem Cells – Researchers show that human induced pluripotent stem cells differentiate into incipient mesoderm-like cells, which robustly generate human primordial germ cell-like cells that can be purified using the surface markers EpCAM and INTEGRINα6.
    Photo Reference: Courtesy of Dr. George Daley of the Harvard Stem Cell Institute
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    1 hr 10 min
  • Ep. 49: SCP Sweden Part 2 – Live Interviews from the ISSCR Conference in Sweden 2015
    Guest:
    In this episode we give you the second part of our broadcast live from the ISSCR 2015 International Conference from Stockholm, Sweden. On the show, we randomly pull attendees aside and ask them to us their stem cell story, and detail some of their research topics and accomplishments. Some of those interviewed on the show include Dr. Sean Morrison, the President of ISSCR, and Dr. Paul Tesar of Case Western Reserve University.
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    2 hr 30 min
  • Ep. 48: SCP Sweden Part 1 – Live Interviews from the ISSCR Conference in Sweden 2015
    Guest:
    In this episode we broadcast live from the ISSCR 2015 International Conference from Stockholm, Sweden.  On the show, we randomly pull attendees aside and ask them to us their stem cell story, and detail some of their research topics and accomplishments.  Everyone from graduate students, post-docs, patients who have received stem cell transplants, to big name researchers, we get them all.
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    2 hr 30 min

About The Stem Cell Podcast

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A podcast dedicated to culturing knowledge in stem cell research. Brought to you by STEMCELL Technologies.

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