Dr. Paul Tesar is the Director of the Institute for Glial Sciences and the Dr. Donald and Ruth Weber Goodman Professor of Innovative Therapeutics at Case Western Reserve University. His lab uses PSCs to model neurological development and disease with a specific focus on oligodendrocytes and astrocytes. He talks about his work on oligodendrocyte maturation, advancing research into the commercial and clinical sectors, and mentoring the next generation of scientists. (42:17)

Spatially Patterned Kidney Assembloids – Genome-edited kidney progenitor assembloids recapitulate hallmarks of human autosomal dominant polycystic kidney disease. (5:50)

Transposable Elements Controlling Cell Fate – This study highlights the role of transposable elements as mechano-response enhancer elements that control human cell fate and gene expression. (13:54)

Cardiac Injury Recovery – Targeting a remote injury response in a non-cardiomyocyte cell type rapidly promotes post-myocardial infarction recovery of non-regenerative hearts. (22:47)

Intestinal Fibrosis in Crohn’s Disease – A mouse model of creeping fat recapitulates key features of Crohn’s disease strictures. (31:40)

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