The Stem Cell Podcast

Guest:

Dr. Valentina Fossati from the New York Stem Cell Foundation, talks about her recent publication using iPSCs to generate the oligodendrocytes, the cells that myelinate neurons and its implications for multiple sclerosis.

Resources and Links

Vaccines—Calling the Shots

Study Finds Blood Type and Memory Loss Link

Textbook Theory Behind Volcanoes May Be Wrong

UV Light Can Turn Gene Into Source of Skin Cancers, Researchers Find

UCLA Biologists Delay The Aging Process By ‘Remote Control’

Eating Habits, Body Fat Related To Differences In Brain Chemistry

Can Sleep Loss Affect Your Brain Size?

First Neanderthal Rock Engraving Found in Gibraltar

Composition of Earth’s mantle revisited thanks to research at Argonne’s Advanced Photon Source

Marijuana Compound May Offer Treatment For Alzheimer’s Disease, USF Preclinical Study Finds

Neuroscientists Reverse Memories’ Emotional Associations

Scripps Research Institute Scientists Link Alcohol-Dependence Gene to Neurotransmitter

Estrogens Stimulate Serotonin Neurons to Inhibit Binge-Like Eating In Mice

Physically Fit Kids Have Beefier Brain White Matter Than Their Less-Fit Peers

Sexually Dimorphic RB Inactivation Underlies Mesenchymal Glioblastoma Prevalence in Males

FDA-Approved Drug Restores Hair in Patients with Alopecia Areata

Obituary: Yoshiki Sasai 1962–2014

Nature Reviewers Not Persuaded by Initial STAP Stem Cell Papers

Japanese Woman Is First Recipient of Next-Generation Stem Cells

Resetting Transcription Factor Control Circuitry toward Ground-State Pluripotency in Human

Diabetes Researchers Find Faster Way to Create Insulin-Producing Cells

Stem Cells Help Researchers Understand How Schizophrenic Brains Function

The Developmental Potential of iPSCs Is Greatly Influenced by Reprogramming Factor Selection

Conversion of Human Fibroblasts into Monocyte-Like Progenitor Cells

Adult Hepatocytes Are Generated by Self-Duplication Rather than Stem Cell Differentiation

Chemical Conversion of Human Fibroblasts into Functional Schwann Cells

Efficient Generation of Myelinating Oligodendrocytes from Primary Progressive Multiple Sclerosis Patients by Induced Pluripotent Stem Cells

Photo Reference: Courtesy of Dr. Valentina Fossati

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Guest:

Dr. Austin Smith from Cambridge UK is on the show to discuss his take on the world of all things pluripotency. We talk about his views on the ground state of pluripotency and how he attempted to drill down into the essential components of the pluripotency network using computer modeling.

Resources and Links

Gut Bacteria That Protect against Food Allergies Identified

A Long Childhood Feeds the Hungry Human Brain

First Intact Organ Built from Cells

Clear Solar Panel Could Turn Smartphones and Tablets into Mini Power Plants, Michigan Researchers Say

Methane Is Bubbling Up From Hundreds of Places Along the U.S. East Coast Seafloor

Plant Development. Arabidopsis NAC45/86 Direct Sieve Element Morphogenesis Culminating in Enucleation.

Ohio Catholic Diocese Discourages ALS Ice Bucket Challenge

Children with Autism Have Extra Synapses in Brain

Transcriptomic Analysis of Tail Regeneration in the Lizard Anolis carolinensis Reveals Activation of Conserved Vertebrate Developmental and Repair Mechanisms

Traces of One of Universe's First Stars Detected

Cold, Dark and Alive! Life Discovered in Buried Antarctic Lake

This Could Explain Why Older Adults Can’t Stay Asleep

Biological Pacemaker Created By Minimally Invasive Somatic Reprogramming in Pigs with Complete Heart Block

Injected Bacteria Shrink Tumors in Rats, Dogs and Humans

Catholic Church Warns Pro-Lifers About Ice Bucket Challenge Donations

In Japan, Official Effort to Replicate STAP Stem Cells Comes Up Empty

Canadian Doctors Use Stem Cells to Treat 'Stiff Person Syndrome'

Stem Cell Trial for Spinal Cord Injuries Cleared By FDA

Rogue Stem Cell Therapy Operators Charging Thousands For Ineffective Treatments, Researchers Say

Boron Facilitates Stem Cell Growth and Development in Corn

Systematic Identification of Culture Conditions for Induction and Maintenance of Naive Human Pluripotency

Generation of Multipotent Induced Neural Crest by Direct Reprogramming of Human Postnatal Fibroblasts with a Single Transcription Factor

Targeting Self-Renewal in High-Grade Brain Tumors Leads to Loss of Brain Tumor Stem Cells and Prolonged Survival

Photo Reference: Courtesy of Dr. Austin Smith

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Guest:

Dr. Paul Knoepfler joins us to recap the STAP cell story in the light of the tragic death of Dr. Yoshiki Sasai. We also discuss a wide variety of topics related to publishing in science.

Resources and Links

Thousand-Strong Robot Swarm Throws Shapes, Slowly

SAGE Publications Busts “Peer Review And Citation Ring,” 60 Papers Retracted

Could a Dissolvable, Drug-Loaded Tampon Protect against HIV?

Why Living in the Moment Is Impossible

Our Brains Judge a Face’s Trustworthiness – Even When We Can’t See It

Growing Human GI Cells May Lead to Personalized Treatments

The Alzheimer's Cure That Worked on Mice

Clues To Curbing Obesity Found in Neuronal ‘Sweet Spot’

Breast Cancer's BRCA1 and BRCA2 Not the Only Gene Mutations to Worry About: Who Should Care about PALB2

Stanford Scientists Create Remote-Controlled Nanoscale Protein Motors

Stanford Bioengineering Team Builds Molecular Motors

Pepper and Halt: Spicy Chemical May Inhibit Gut Tumors

Study of Twins Discovers Gene Mutation Linked to Short Sleep Duration

Deletion of the Mitochondrial Chaperone TRAP-1 Uncovers Global Reprogramming of Metabolic Networks

Otzi Iceman Had Genetic Predisposition for Atherosclerosis: Much the Same in Ancient Peoples as It Is Today

Potential 'Universal' Blood Test For Cancer Discovered

Japanese Researcher, an Author of a Discredited Stem Cell Study, Is Dead

Brigham Researcher in Flawed Stem Cell Study Will Step Down

Transparency Promised for Vilified Impact Factor

A Stem Cell Study Shows Promising Results for Severe Stroke Patients

Stem Cell Research Gets Huge Boost from Australian Zebrafish Discovery

Stem Cells Reveal How Illness-Linked Genetic Variation Affects Neurons

A Simple And Efficient Method for Transfecting Mouse Embryonic Stem Cells Using Polyethylenimine

Seamless Gene Correction of Beta-Thalassemia Mutations in Patient-Specific Cells

Effect of Human Donor Cell Source on Differentiation and Function of Cardiac Induced Pluripotent Stem Cells

Generation of Rat-Induced Pluripotent Stem Cells from a New Model of Metabolic Syndrome

Photo Reference: Courtesy of Dr. Paul Knoepfler

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Guest:

Dr. Marco Seandel from Weill Cornell Medical College joins the hosts to talk about his latest paper published in Stem Cell Reports, where he used sperm stem cells to uncover novel info about mutations in aged male sperm.

Resources and Links

Learning The Smell Of Fear: Mothers Teach Babies Their Own Fears Via Odor, Animal Study Shows

The Habenula Encodes Negative Motivational Value Associated with Primary Punishment in Humans

A Highly Abundant Bacteriophage Discovered in the Unknown Sequences of Human Faecal Metagenomes

Mysterious X-rays Might Hint at Dark Matter

Researchers Find First Sign that Tyrannosaurs Hunted in Packs

The Black Death in China

Longitudinal Changes in Total Brain Volume in Schizophrenia: Relation to Symptom Severity, Cognition and Antipsychotic Medication

Junk Food Could Destroy Your Sense of SMELL, Scientists Warn

Mechanisms of CFTR Functional Variants That Impair Regulated Bicarbonate Permeation and Increase Risk for Pancreatitis but Not for Cystic Fibrosis

Genetic Cause of Common Breast Tumors Found

Lawsuit Claims Stem Cells Unsafe

California's Stem Cell Scandal Gets Worse

Sugar Mimic Helps Embryonic Stem Cells Develop Toward Nerve Cells

Teeth Sprout from Glia-Derived Stem Cells

Stem Cell Research Could Lead to New Muscle Repair Treatments

Stem Cell Therapy Could Lead to HIV Cure

Functional and Molecular Defects of Hipsc-Derived Neurons from Patients with ATM Deficiency

Spider Silk for Xeno-Free Long-Term Self-Renewal and Differentiation of Human Pluripotent Stem Cells

Role of Astroglia in Down's Syndrome Revealed by Patient-Derived Human-Induced Pluripotent Stem Cells

Generation Of Induced Pluripotent Stem Cells From Virus Freein Vivo Reprogramming of BALB/C Mouse Liver Cells

Gene Expression Variability as a Unifying Element of the Pluripotency Network

Enhanced Fitness of Adult Spermatogonial Stem Cells Bearing a Paternal Age-Associated FGFR2 Mutation

Photo Reference: Courtesy of Dr. Marco Seandel

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Guest:

Dr. Daylon James is back on the show to talk about a new paper in Nature where scientists used a vascular niche to help instruct and reprogram endothelial cells to blood stem cells.

Resources and Links

WHO: Ebola Outbreak Deaths in West Africa hit 603

Friends Are the Family You Choose: Genome-Wide Analysis Reveals Genetic Similarities among Friends

Oldest Case of Down Syndrome Discovered in 1,500-Year-Old Skeleton

Cracking the Code of How the Brain Processes Emotions

What Causes Autism? Rare Mutation in the CHD8 Gene May Be Responsible for Autism Subtype

New Alzheimer’s Test May Help Future Clinical Trials

Coffee Reduces the Risk of Parkinson's Disease

‘Asian Flush’ Signals Drinkers to Ease Up on Alcohol

Pelagornis sandersi: Paleontologist Discovers Largest-Ever Flying Bird

EU Court Adviser Backs Stem Cell Patenting

Large Study of Stem Cells for Autism Draws Criticism

Experimental Stem Cell Treatment Causes Woman To Grow Parts Of A Nose On Her Spine

Ground-Breaking Stem Cell Technique Developed To Heal Fractures And Prevent Amputations

Gene Profiling Technique to Accelerate Stem Cell Therapies for Eye Diseases

A Method To Recapitulate Early Embryonic Spatial Patterning in Human Embryonic Stem Cells

Biological Pacemaker Created by Minimally Invasive Somatic Reprogramming in Pigs with Complete Heart Block

Direct Induction of Haematoendothelial Programs in Human Pluripotent Stem Cells by Transcriptional Regulators

Reprogramming Human Endothelial Cells to Haematopoietic Cells Requires Vascular Induction

Photo Reference: Courtesy of Dr. Daylon James

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Guest:

This episode presents Dr. Paul Tesar from Case Western Reserve University. Dr Tesar talks about his paper in Cell Stem Cell.

Resources and Links

Bone Marrow Transplant Could Reverse Sickle Cell In Adults

Freezing Testicle Tissue in Mice Offers Fertility Hope for Cancer Survivors

Alzheimer's Linked to Brain Hyperactivity

Obesity Linked To Type 2 Diabetes by an Absent Protein

New Diabetes Drug Could Retrain GI Cells To Produce Insulin By Switching Off One Gene

Not All Stem Cells Created Equal

STAP Retracted

Supermassive Black Hole Obscures Heart of Galaxy with 'Rare and Powerful Stream of Gas'

Virus Kills Triple Negative Breast Cancer Cells, Tumor Cells in Mice

Torsina Hypofunction Causes Abnormal Twisting Movements and Sensorimotor Circuit Neurodegeneration

Destroying Bacterial Cell Walls May End Antibiotic Resistance Forever

If Blocked Endocannabinoids Trigger Dementia Symptoms, Could Cannabis Prevent Alzheimer’s?

Minimal Toolkit for Stem Cell Self-Renewal

Dinosaurs Were Mesothermic Beasts, Neither Warm-Blooded Nor Cold-Blooded

Geron hESC Trial to Resume?

Stem Cells Form Light-Sensitive 3-D Retinal Tissue

Delivering Capsules of Stem Cells Helps Repair Injured Bones

Study Identifies Link Between Gut Bacteria Post SCT Survival

Stem Cells Slow Retinal Degeneration in Dry AMD Clinical Trial

Sustained ERK Activation Underlies Reprogramming in Regeneration-Competent Salamander Cells and Distinguishes Them from Their Mammalian Counterparts

Human ESC-Derived MSCs Outperform Bone Marrow MSCs in the Treatment of an EAE Model of Multiple Sclerosis

An iCRISPR Platform for Rapid, Multiplexable, and Inducible Genome Editing in Human Pluripotent Stem Cells

Epigenomic Comparison Reveals Activation of “Seed” Enhancers during Transition from Naive to Primed Pluripotency

Photo Reference: Courtesy of Dr. Paul Tesar

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Guest:

This is a special episode consisting of over 75 minutes of live interviews. Last week The Stem Cell Podcast attended the International Society for Stem Cell Research meeting and pulled people aside to get their take on the meeting and stem cell research. We compiled all the interviews into one show for you to enjoy.

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Guest:

Dr. Dieter Egli from the New York Stem Cell Foundation joins the hosts to talk about his work in using SCNT to derive new embryonic stem cell lines. They discuss his previous and current work, including his latest story published in Nature.

Resources and Links

Sensing of Amino Acids in a Dopaminergic Circuitry Promotes Rejection of an Incomplete Diet in Drosophila

Histone Modifications Are Associated with Delta(9)-Tetrahydrocannabinol-Mediated Alterations in Antigen-Specific T Cell Responses

Compound in Saliva Helps Protect Our Cells from Toxins in Coffee, Tea, Study Shows

A Molecular Basis for Classic Blond Hair Color in Europeans

Engineering a Memory with LTD and LTP

Green Tea Component Upsets Cancer Cell Metabolism

Photoactivation of Endogenous Latent Transforming Growth Factor–β1 Directs Dental Stem Cell Differentiation for Regeneration

Targeting CXCL12 From FAP-Expressing Carcinoma-Associated Fibroblasts Synergizes with Anti–PD-L1 Immunotherapy in Pancreatic Cancer

Fighting Back: Patient's Own Immune Cells Tackle Cervical Cancer

A Draft Map of the Human Proteome

Abnormal Neuronal Differentiation and Mitochondrial Dysfunction in Hair Follicle-Derived Induced Pluripotent Stem Cells of Schizophrenia Patients

Role of the Primate Ventral Tegmental Area in Reinforcement and Motivation

Tai Chi Intervention Increases Progenitor CD34+ Cells in Young Adults

Unconditional Quantum Teleportation between Distant Solid-State Quantum Bits

Remission of Disseminated Cancer after Systemic Oncolytic Virotherapy

Less Pain (Receptors) Means a Longer Life

Mice with Mohawks Reveal Two Biological Pathways Linked with Autism Behaviors

CC Sabathia Ready to Throw for First Time since Stem-Cell Treatment for Knee

New Record Highs In Moral Acceptability - Premarital Sex, Embryonic Stem Cell Research, Euthanasia Growing in Acceptance

The Broad Foundation Advances Stem Cell Research at USC

Obokata Agrees to STAP Experiment

Inside a Corrupt Stem Cell Research Lab

EU Commission Rejects Petition to Stop Funding Embryonic Stem Cell Research

Blonde Is Just a Matter of a Tiny Stem Cell Molecule Tweak, Says New Research

Modulating Innate Immunity Improves Hepatitis C Virus Infection and Replication in Stem Cell-Derived Hepatocytes

The Age and Genomic Integrity of Neurons after Cortical Stroke in Humans

Photo Reference: Courtesy of Dr. Dieter Egli

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The Stem Cell Podcast HostsDr. Fasano and Dr. Ganat

On this episode we review the Next Gen Stem Cell Conference from earlier in the month.  During the conference we interviewed 5 stem cell scientists live and put them all together for this show.  In addition to these great guests, we review the literature as always. Topics include the biggest sperm ever, C-kit+ stem cells don't make heart, heart on a chip technology, a new element on the periodic table, and iPSCs from schizophrenia patients.  After that, we end with a rant about bathroom air fresheners!

Resources, Links and Research Papers Mentioned In This Session Include:

World's Oldest Sperm Discovered: 17-Million-Year-Old Cell Is Longer Than Its Creator

Researchers Identify Link Between Colon Cancer And Metabolism

In Vivo Modulation Of Hypoxia-Inducible Signaling By Topographical Helix Mimetics.

Heart Cells Have 'Preteen' Growth Spurt

An Antidepressant Decreases CSF Aβ Production in Healthy Individuals and in Transgenic AD Mice

New Super-Heavy Element 117 Confirmed By Scientists

Autism-Related Protein Shown to Play Vital Role in Addiction

Chd5 Orchestrates Chromatin Remodelling During Sperm Development

‘Heart Disease-On-A-Chip’

Syphilis Made A Big Comeback In 2013, CDC Warns

Life Extension Factor Klotho Enhances Cognition

Meet HD 162826, The Sister Star Of Our Sun

Novel Antioxidant Makes Old Arteries Seem Young Again, Study Shows

Scripps Research Institute Scientists Create First Living Organism that Transmits Added Letters in DNA 'Alphabet'

Model Universe Recreates Evolution Of The Cosmos

Long-Snouted Tyrannosaur Unearthed

Vampire's Delight? Young Blood Recharges Brains of Old

Fate of iPSCs Derived from Azoospermic and Fertile Men following Xenotransplantation to Murine Seminiferous Tubules

Hope For Aging Brains, Skeletal Muscle

Stem Cell Therapy Saves Eyesight Of Fountain Valley Mother

c-kit+ Cells Minimally Contribute Cardiomyocytes To The Heart

Study Questions Use Of Stem Cells To Repair Heart

Modeling The Mitochondrial Cardiomyopathy Of Barth Syndrome With Induced Pluripotent Stem Cell And Heart-On-Chip Technologies

Phenotypic Differences In Hipsc Npcs Derived From Patients With Schizophrenia.

Recombinase-Mediated Reprogramming and Dystrophin Gene Addition in mdx Mouse Induced Pluripotent Stem Cells

U.S. Biomedical Research 'Unsustainable,' Prominent Researchers Warn

Rescuing US Biomedical Research From Its Systemic Flaws

We are working on a way to categorize all of the research papers we mention on the show and provide, possibly even provide audio summaries.  Enter in your name and e-mail address below, and we will notify you of when this feature is available.

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Guest:

Dr. Kevin Eggan from Harvard University joins the show to talk about his latest work using stem cells to cure ALS/Lou Gehrig’s disease.

Resources and Links

Fate of iPSCs Derived from Azoospermic and Fertile Men following Xenotransplantation to Murine Seminiferous Tubules

Hope for Aging Brains, Skeletal Muscle

Pain Curbs Sex Drive in Female Mice, but Not in Males

New Virus Related To Smallpox Is Found in Republic Of Georgia

Male Researchers Stress Out Rodents

Scripps Florida Scientists Find Connection Between Gene Mutation, Key Symptoms of Autism

Soy-Dairy Protein Blend and Whey Protein Ingestion After Resistance Exercise Increases Amino Acid Transport and Transporter Expression in Human Skeletal Muscle

Push Comes to Shove: Gilead's $1,000 Pill Could Hurt Insurer Earnings

Death Rates From Pancreatic Cancer Predicted to Rise in Europe in 2014

Human CLP1 Mutations Alter tRNA Biogenesis, Affecting Both Peripheral and Central Nervous System Function

Y chromosome is Not Disappearing, Researchers Say

Loss Of Memory Reversed in Alzheimer's Mice Models

MRSA Spreads in Households

REDD1 is Essential for Stress-Induced Synaptic Loss and Depressive Behavior

Amyloid Precursor Protein Regulates Neurogenesis by Antagonizing Mir-574-5p in the Developing Cerebral Cortex

Japanese Nobel Winner Latest to Apologize Over Stem-Cell Research

RIKEN to Check 20,000 Papers for Doctored Images and Plagiarism

Stem Cells and the "Staircase of Shame"

Stem Cells May Be Key to Long Life: Research on Body of 115-Year-Old Woman

How Silly Putty May Advance Stem Cell Research

First Stem Cells Cloned From Diabetes Patient, Thanks to Egg Donors

Human Oocytes Reprogram Adult Somatic Nuclei of a Type 1 Diabetic to Diploid Pluripotent Stem Cells

Human Embryonic-Stem-Cell-Derived Cardiomyocytes Regenerate Non-Human Primate Hearts

Infertility: Stem Cell-Based Sperm Created From Infertile Mens Skin

Reprogramming Committed Murine Blood Cells to Induced Hematopoietic Stem Cells with Defined Factors

A 3D Sphere Culture System Containing Functional Polymers for Large-Scale Human Pluripotent Stem Cell Production

3D In Vitro Model of a Functional Epidermal Permeability Barrier from Human Embryonic Stem Cells and Induced Pluripotent Stem Cells

Photo Reference: Courtesy of Dr. Kevin Eggan

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