President Donald Trump said the U.S. has struck Iranian nuclear sites, escalating the Israel-Iran conflict. Retired U.S. Army Col. Jack Jacobs explains the strategic impact of the attack and what Iran might do next. CNBC’s Emily Wilkins covers the reaction in Washington and gives an update on President Trump’s Big Beautiful Bill. Then, Gilead Sciences CEO Daniel O’Day talks about the FDA approval of Yeztugo, a twice-yearly HIV prevention drug, and its importance in public health. Plus, Pixar’s Elio sees the worst box office opening in the studio’s history.

Col. Jack Jacobs - 05:06

Emily Wilkins - 17:39

Daniel O'Day - 24:20

In this episode:

Emily Wilkins, @emrwilkins

Becky Quick, @BeckyQuick

Joe Kernen, @JoeSquawk

Andrew Ross Sorkin, @andrewrsorkin

Zach Vallese, @zachvallese