This Week In Medicine

Hi, This Week in Medicine, we will be discussing

 New England Journal of Medicine

Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes

Efficacy and Safety of an mRNA-Based RSV PreF Vaccine in Older Adults

Recombinant or Standard-Dose Influenza Vaccine in Adults under 65 Years of Age

Three-Year Overall Survival with Tebentafusp in Metastatic Uveal Melanoma

 Annals of Internal Medicine

Development and Validation of the CANHEART Population-Based Laboratory Prediction Models for Atherosclerotic Cardiovascular Disease

 Nature Medicine

Inhibition of the KCa2 potassium channel in atrial fibrillation: a randomized phase 2 trial

  Lancet

Pembrolizumab plus chemotherapy versus chemotherapy in untreated advanced pleural mesothelioma in Canada, Italy, and France: a phase 3, open-label, randomised controlled trial

 Journal of Clinical Oncology

High-Dose Methotrexate as CNS Prophylaxis in High-Risk Aggressive B-Cell Lymphoma

 journal of Hepatology

Bifidobacterium pseudolongum-generated acetate suppresses non-alcoholic fatty liver disease-associated hepatocellular carcinoma

Incidence and outcomes of acute kidney injury including hepatorenal syndrome in hospitalized patients with cirrhosis in the US

 Clinical Gastroenterology

Reflux Symptoms Increase Following Sleeve Gastrectomy Despite Triage of Symptomatic Patients to Roux-en-Y Gastric Bypass

Safety and Efficacy of Endoscopic Full Thickness Resection of Upper Gastrointestinal Lesions Using a Full Thickness Resection Device: A Systematic Review and Meta-analysis

  Clinical Infectious Diseases

Patient Characteristics, Microbiology, and Mortality of Infective Endocarditis After Transcatheter Aortic Valve Implantation

Temporal Trends in Hepatitis C–Related Hospitalizations, United States, 2000–2019

  Journal of Clinical Rheumatology 

Unintentional Monotherapy in Rheumatoid Arthritis Patients Receiving Tofacitinib and Drug Survival Rate of Tofacitinib

 Arthritis and Rheumatology

A Randomized, Double-Blind, Sham-Controlled, Clinical Trial of Auricular Vagus Nerve Stimulation for the Treatment of Active Rheumatoid Arthritis

  Circulation

Rivaroxaban Plus Aspirin Versus Aspirin Alone After Endovascular Revascularization for Symptomatic PAD: Insights From VOYAGER PAD

American College of Cardiology

Predictors of Outcomes in Mild Pulmonary Hypertension 

Safety and Tolerability of Inclisiran for Treatment of Hypercholesterolemia in 7 Clinical Trials

 Journal of Clinical Endocrinology & Metabolism

DI/cle, a Measure Consisting of Insulin Sensitivity, Secretion, and Clearance, Captures Diabetic States

Tissue Glucocorticoid Metabolism in Adrenal Insufficiency: A Prospective Study of Dual-release Hydrocortisone Therapy

 Neurology:

Association of Neighborhood-Level Socioeconomic Factors With Delay to Hospital Arrival in Patients With Acute Stroke

 Chest

CT Scan Differences of Pulmonary TB According to Presence of Pleural Effusion

  The American Journal of Respiratory and Critical Care Medicine

Impact of Undiagnosed Chronic Obstructive Pulmonary Disease and Asthma on Symptoms, Quality of Life, Healthcare Use, and Work Productivity

  Clinical Gastroenterology AND Hepatology

Long-term Risks of Recurrence After Hospital Discharge for Acute Lower Gastrointestinal Bleeding: A Large Nationwide Cohort Study

  Clinical Journal of American Society of Nephrology

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Cystatin C–Based eGFR Changes during Gender-Affirming Hormone Therapy in Transgender Individuals

  Kidney International reports

Sex/Gender-Based Disparities in Early Transplant Access by Attributed Cause of Kidney Disease–Evidence from a Multiregional Cohort in the Southeast United States

Hi, This Week in Medicine, we will be discussing

First we will be discussing articles in New England Journal of Medicine

Sotorasib plus Panitumumab in Refractory Colorectal Cancer with Mutated KRAS G12C

Baricitinib and β-Cell Function in Patients with New-Onset Type 1 Diabetes

Teplizumab and β-Cell Function in Newly Diagnosed Type 1 Diabetes

Mirvetuximab Soravtansine in FRα-Positive, Platinum-Resistant Ovarian Cancer

Journal of  American Medical Association

Sintilimab Plus Chemotherapy for Unresectable Gastric or Gastroesophageal Junction Cancer: The ORIENT-16 Randomized Clinical Trial

Pregnancy After Breast Cancer in Young BRCA Carriers

  Annals of Internal Medicine

Second-Line Chimeric Antigen Receptor T-Cell Therapy in Diffuse Large B-Cell Lymphoma

 Lancet

Pembrolizumab plus trastuzumab and chemotherapy for HER2-positive gastric or gastro-oesophageal junction adenocarcinoma: interim analyses from the phase 3 KEYNOTE-811 randomised placebo-controlled trial

  Journal of Clinical Oncology

Effect of Metformin Versus Placebo on New Primary Cancers in Canadian Cancer Trials Group MA.32: A Secondary Analysis of a Phase III Randomized Double-Blind Trial in Early Breast Cancer

  Journal of Hepatology

Bifidobacterium pseudolongum-generated acetate suppresses non-alcoholic fatty liver disease-associated hepatocellular carcinoma

  Clinical Gastroenterology

Long-term Risks of Recurrence After Hospital Discharge for Acute Lower Gastrointestinal Bleeding: A Large Nationwide Cohort Study

 Blood

Clinical Outcomes in Patients with High-Dose Methotrexate Toxicity Treated with Vs. without Glucarpidase

 Clinical Infectious Diseases

Diagnostic Accuracy of Hospital Antibiograms in Predicting the Risk of Antimicrobial Resistance in Enterobacteriaceae Isolates: A Nationwide Multicenter Evaluation at the Veterans Health Administration

 Journal of Clinical Rheumatology 

Unintentional Monotherapy in Rheumatoid Arthritis Patients Receiving Tofacitinib and Drug Survival Rate of Tofacitinib

  Arthritis and Rheumatology

Poly-refractory Rheumatoid Arthritis: An Uncommon Subset of Difficult to Treat Disease with Distinct Inflammatory and Non-inflammatory Phenotypes

  Circulation

Bag-Valve-Mask Ventilation and Survival From Out-of-Hospital Cardiac Arrest: A Multicenter Study

American College of Cardiology

Long-Term Safety of Inclisiran for Treatment of Hypercholesterolemia

 Journals of the American College of Cardiology

Safety and Tolerability of Inclisiran for Treatment of Hypercholesterolemia in 7 Clinical Trials

  Journal of Clinical Endocrinology & Metabolism

Effective GH Replacement With Somapacitan in Children With GHD: REAL4 2-year Results and After Switch From Daily GH

  Neurology:

Association Between Diseases and Symptoms Diagnosed in Primary Care and the Subsequent Specific Risk of Multiple Sclerosis

 Chest

Multiplex Polymerase Chain Reaction Assay to Detect Nasopharyngeal Viruses in Immunocompromised Patients With Acute Respiratory Failure

  The American Journal of Respiratory and Critical Care Medicine

Inflammatory Molecular Endotypes in Bronchiectasis: A European Multicenter Cohort Study

 Clinical and Translational Gastroenterology 

Non-Pure Intestinal Phenotype as an Indicator of Progression in Sporadic Non-ampullary Duodenal Adenomas: A Multicenter Retrospective Cohort Study

  Clinical Journal of American Society of Nephrology

.

Nurse Practitioner Care Compared with Primary Care or Nephrologist Care in Early CKD

  Kidney International reports

Randomized Trial on the Effect of an Oral Spleen Tyrosine Kinase Inhibitor in the Treatment of IgA Nephropathy

New England Journal of Medicine

Intravenous Levothyroxine for Unstable Brain-Dead Heart Donors

Inhaled Amikacin to Prevent Ventilator-Associated Pneumonia

Tarlatamab for Patients with Previously Treated Small-Cell Lung Cancer

Journal of  American Medical Association

Effect of Noninvasive Airway Management of Comatose Patients With Acute Poisoning

Effect of Personalized Risk-Reduction Strategies on Cognition and Dementia Risk Profile Among Older Adults

The SMARRT Randomized Clinical Trial

Annals of Internal Medicine

Inappropriate Prescribing to Older Patients by Nurse Practitioners and Primary Care Physicians

Nature Medicine

Financial incentives for COVID-19 vaccines in a rural low-resource setting: a cluster-randomized trial

British Medical Journal

Social media use and health risk behaviours in young people: systematic review and meta-analysis

Lancet

Long-term outcomes with biodegradable polymer sirolimus-eluting stents versus durable polymer everolimus-eluting stents in ST-segment elevation myocardial infarction: 5-year follow-up of the BIOSTEMI randomised superiority trial

Journal of Clinical Oncology

Five-Year Overall Survival Analysis of the JIPANG Study: Pemetrexed or Vinorelbine Plus Cisplatin for Resected Stage II-IIIA Nonsquamous Non–Small-Cell Lung Cancer

Hepatology

Duration of type 2 diabetes and liver-related events in nonalcoholic fatty liver disease: A landmark analysis

Clinical Gastroenterology

 The Impact of Intermittent Fasting on Patients With Suspected Gastroesophageal Reflux Disease

Clinical Infectious Diseases

Prevalence of Comorbid Factors in Patients With Recurrent Clostridioides difficile Infection in ECOSPOR III, a Randomized Trial of an Oral Microbiota–Based Therapeutic

Journal of infectious Diseases

Incidence of Cytomegalovirus Primary and Secondary Infection in Adolescent Girls: Results From a Prospective Study

Journal of Clinical Rheumatology 

Hip Abductor Weakness and Its Association With New or Worsened Knee Pain: Data From the Multicenter Osteoarthritis Study

Efficacy and Safety of Sublingual Cyclobenzaprine for the Treatment of Fibromyalgia: Results From a Randomized, Double-Blind, Placebo-Controlled Trial

 Arthritis and Rheumatology

A Randomized, Double-Blind, Sham-Controlled, Clinical Trial of Auricular Vagus Nerve Stimulation for the Treatment of Active Rheumatoid Arthritis

 Circulation

Outpatient Worsening Among Patients With Mildly Reduced and Preserved Ejection Fraction Heart Failure in the DELIVER Trial

 American College of Cardiology

Stroke and Bleeding Risk in AF With CHA2DS2-VASc Score of One

  Journals of the American College of Cardiology

Comparison of Intravascular Imaging, Functional, or Angiographically Guided Coronary Intervention

 Journal of Clinical Endocrinology & Metabolism

DI/cle, a Measure Consisting of Insulin Sensitivity, Secretion, and Clearance, Captures Diabetic States

 Neurology:

Short-term Exposure to Air Pollution and Ischemic Stroke

A Systematic Review and Meta-analysis

  Chest

Liberation From Venovenous Extracorporeal Membrane Oxygenation for Respiratory Failure

 The American Journal of Respiratory and Critical Care Medicine

Indoor Pollution and Lung Function Decline in Current and Former Smokers: SPIROMICS AIR

  Clinical and Translational Gastroenterology 

Proton Pump Inhibitor use and Complications of Cirrhosis Are Linked with Distinct Gut Microbial Bacteriophage and Eukaryotic Viral Like Particle Signatures in Cirrhosis

 Clinical Gastroenterology AND Hepatology

Health-related Quality of Life in Patients With Nonalcoholic Fatty Liver Disease: A Prospective Multi-center UK Study

Real-World Experience With Tofacitinib Dose De-Escalation in Patients With Moderate and Severe Ulcerative Colitis

 Clinical Journal of Kidney International

Changes in Bone Quality after Treatment with Etelcalcetide

Comparison of Short-Term Outcomes in Kidney Transplant Recipients from SARS-CoV-2–Infected versus Noninfected Deceased Donors

 Kidney International reports

Prospective Cohort Study of Soluble Urokinase Plasminogen Activation Receptor and Cardiovascular Events in Patients With CKD

Hi, This Week in Medicine, we will be discussing recently published articles.

 New England Journal of Medicine

Osimertinib with or without Chemotherapy in EGFR-Mutated Advanced NSCLC

Transcatheter Aortic-Valve Replacement in Low-Risk Patients at Five Years

Erdafitinib or Chemotherapy in Advanced or Metastatic Urothelial Carcinoma

  Journal of  American Medical Association

Small-Volume Blood Collection Tubes to Reduce Transfusions in Intensive Care: The STRATUS Randomized Clinical Trial

 Annals of Internal Medicine

Relationship Between Clinician Language and the Success of Behavioral Weight Loss Interventions

  British Medical Journal

Blood cell differential count discretisation modelling to predict survival in adults reporting to the emergency room: a retrospective cohort study 

 Journal of Clinical Oncology

ROSEWOOD: A Phase II Randomized Study of Zanubrutinib Plus Obinutuzumab Versus Obinutuzumab Monotherapy in Patients With Relapsed or Refractory Follicular Lymphoma

Homoharringtonine-Based Induction Regimen Improved the Remission Rate and Survival Rate in Chinese Childhood AML: A Report From the CCLG-AML 2015 Protocol Study

Hepatology

Abdominal pain in patients with inflammatory bowel disease in remission

  Clinical Gastroenterology AND Hepatology

Adding Inflammatory Markers and Refining National Institute on Alcohol Abuse and Alcoholism Criteria Improve Diagnostic Accuracy for Alcohol-associated Hepatitis

Association Between the Presence of Metabolic Comorbidities and Liver-Related Events in Patients With Chronic Hepatitis B

  Clinical Infectious Diseases

Pleural Empyema Caused by Streptococcus intermedius and Fusobacterium nucleatum: A Distinct Entity of Pleural Infections

 Journal of infectious Diseases

Stability and Inactivation of Monkeypox Virus on Inanimate Surfaces

  Journal of Clinical Rheumatology 

How Does Exercise, With and Without Diet, Improve Pain and Function in Knee Osteoarthritis? A Secondary Analysis of a Randomized Controlled Trial Exploring Potential Mediators of Effects

Prevalence of Nonsteroidal Antiinflammatory Drugs Prescribed for Osteoarthritis: A Systematic Review and Meta-Analysis of Observational Studies

 Arthritis and Rheumatology

Large-Scale Analysis of Meniscus Morphology as Risk Factor for Knee Osteoarthritis

Risk–Benefit Analysis of Primary Prophylaxis Against Pneumocystis Jirovecii Pneumonia in Patients With Rheumatic Diseases Receiving Rituximab

  Circulation October 24, 2023 

Longitudinal Follow-Up of Children With HLHS and Association Between Norwood Shunt Type and Long-Term Outcomes: The SVR III Study

American College of Cardiology

 Antithrombotic Regimens After Left Atrial Appendage Occlusion

Dapagliflozin in Patients With Heart Failure and Deterioration in Renal Function

  Journal of Clinical Endocrinology & Metabolism

Diurnal Range and Intra-patient Variability of ACTH Is Restored With Remission in Cushing's Disease

  Neurology:

Performance of a [18F]Flortaucipir PET Visual Read Method Across the Alzheimer Disease Continuum and in Dementia With Lewy Bodies

  Chest

Microbiological Cure at Treatment Completion Is Associated With Longer Survival in Patients With Mycobacterium avium Complex Pulmonary Disease

  The American Journal of Respiratory and Critical Care Medicine

Combination of BAL and Computed Tomography Differentiates Progressive and Non-progressive Fibrotic Lung Diseases

  Clinical and Translational Gastroenterology 

Real-Time Evaluation of Helicobacter pylori Infection by Convolution Neural Network During White-Light Endoscopy: A Prospective, Multicenter Study

  Clinical Journal of American Society of Nephrology

Rare Variants in Complement Gene in C3 Glomerulopathy and Immunoglobulin-Mediated Membranoproliferative GN

Taurolidine/Heparin Lock Solution and Catheter-Related Bloodstream Infection in Hemodialysis: A Randomized, Double-Blind, Active-Control, Phase 3 Study

  Kidney International reports

Randomized Trial Comparing SGLT2 Inhibition and Hydrochlorothiazide on Sympathetic Traffic in Type 2 Diabetes

Hi, This Week in Medicine, we will be discussing recently published articles.

New England Journal of Medicine

First-Line Selpercatinib or Chemotherapy and Pembrolizumab in RET Fusion–Positive NSCLC 

 Phase 3 Trial of Selpercatinib in Advanced RET-Mutant Medullary Thyroid Cancer 

 Two Phase 3 Trials of Gantenerumab in Early Alzheimer’s Disease 

 Arginine or Hypertonic Saline–Stimulated Copeptin to Diagnose AVP Deficiency 

 Journal of  American Medical Association

Effect of Dietary Sodium on Blood PressureA Crossover Trial 

 Intravenous Vitamin C for Patients Hospitalized With COVID-19 

Two Harmonized Randomized Clinical Trials 

 Multitarget Stool RNA Test for Colorectal Cancer Screening 

 Hypertension journal

Different Home Blood Pressure Thresholds to Predict Perfect 24-Hour Ambulatory Blood Pressure Control in Treated Hypertension Based on an “All-in-One” Device

 Annals of Internal Medicine

Atezolizumab With or Without Radiotherapy for Advanced Squamous Cell Carcinoma of the Penis (The PERICLES Study): A Phase II Trial

Journal of Clinical Oncology

Zanubrutinib Versus Ibrutinib in Symptomatic Waldenström Macroglobulinemia: Final Analysis From the Randomized Phase III ASPEN Study

 Hepatology

Microscopic colitis and risk of incident rheumatoid arthritis

  Clinical Gastroenterology

The Impact of Intermittent Fasting on Patients With Suspected Gastroesophageal Reflux Disease

  Clinical Infectious Diseases

Pleural Empyema Caused by Streptococcus intermedius and Fusobacterium nucleatum

  Journal of infectious Diseases

Hepatitis B e Antigen-Negative Single Hepatocyte Analysis Shows Transcriptional Silencing and Slow Decay of Infected Cells With Treatment

 Journal of Clinical Rheumatology 

Barriers and Enablers in the Use of Parenteral Methotrexate in Rheumatoid Arthritis Patients: A Scoping Review

  Arthritis and Rheumatology

Association of Interosseous Tendon Inflammation in the Hand With Different Early Arthritides in a 10-Year Magnetic Resonance Imaging Study

Association Between Plasma Rituximab Concentration and the Risk of Major Relapse in Antineutrophil Cytoplasmic Antibody–Associated Vasculitides During Rituximab Maintenance Therapy

  Circulation October 24, 2023 

Inhaled Epoprostenol Compared With Nitric Oxide for Right Ventricular Support After Major Cardiac Surgery

American College of Cardiology

SGLT2 Inhibitors for Cancer Therapy–Related Cardiac Dysfunction 

  Journal of Clinical Endocrinology & Metabolism

Effects of Aerobic Training and Semaglutide Treatment on Pancreatic β-Cell Secretory Function in Patients With Type 2 Diabetes

 Neurology:

Eligibility for Anti-Amyloid Treatment in a Population-Based Study of Cognitive Aging

  Chest

 Preserved Ratio Impaired Spirometry and Risks of Macrovascular, Microvascular Complications and Mortality Among Individuals With Type 2 Diabetes

 The American Journal of Respiratory and Critical Care Medicine

Augmentation Therapy for Severe Alpha-1 Antitrypsin Deficiency Improves Survival and Is Decoupled from Spirometric Decline—A Multinational Registry Analysis

 Clinical Gastroenterology AND Hepatology

Risk of Postcolonoscopy Thromboembolic Events: A Real-World Cohort Study

The Role of Carbamoyl Phosphate Synthetase 1 as a Prognostic Biomarker in Patients With Acetaminophen-induced Acute Liver Failure

  Clinical Journal of American Society of Nephrology

Differences in the Circulating Proteome in Individuals with versus without Sickle Cell Trait

Prostaglandin E2, Osmoregulation, and Disease Progression in Autosomal Dominant Polycystic Kidney Disease

  Kidney International reports

Randomized Study of Tenapanor Added to Phosphate Binders for Patients With Refractory Hyperphosphatemia

Hi, This Week in Medicine, we will be discussing recently published articles.

First we will be discussing articles in New England Journal of Medicine

Severe Hyponatremia Correction, Mortality, and Central Pontine Myelinolysis

Actionable Genotypes and Their Association with Life Span in Iceland

Trial of Botulinum Toxin for Isolated or Essential Head Tremor

 Decolonization in Nursing Homes to Prevent Infection and Hospitalization

Nivolumab plus Gemcitabine–Cisplatin in Advanced Urothelial Carcinoma

  Journal of  American Medical Association

Automated Opt-Out vs Opt-In Patient Outreach Strategies for Breast Cancer Screening

Association of Gestational Diabetes With Subsequent Long-Term Risk of Mortality

Objective  To investigate the associations between gestational diabetes and long-term risks of total and cause-specific mortality.

  Annals of Internal Medicine

Relationship Between Clinician Language and the Success of Behavioral Weight Loss Interventions

  Journal of Clinical Oncology

Adding Ovarian Suppression to Tamoxifen for Premenopausal Women With Hormone Receptor–Positive Breast Cancer After Chemotherapy: An 8-Year Follow-Up of the ASTRRA Trial

 Hepatology

Efficacy and safety of on-demand vonoprazan versus placebo for non-erosive reflux disease

 Clinical Gastroenterology AND Hepatology

Development and Validation of the Veterans Affairs Eosinophilic Esophagitis Cohort

Epidemiologic Burden and Projections for Eosinophilic Esophagitis–Associated Emergency Department Visits in the United States: 2009-2030

 Journal of infectious Diseases

BK Polyomavirus Diversity After Hematopoietic Stem Cell Transplantation

  Journal of Clinical Rheumatology 

Development of American College of Rheumatology Quality Measures for Systemic Lupus Erythematosus: A Modified Delphi Process With Rheumatology Informatics System for Effectiveness (RISE) Registry Data Review

Examination of the Increased Risk for Falls Among Individuals With Knee Osteoarthritis: A Canadian Longitudinal Study on Aging Population-Based Study

 Arthritis and Rheumatology

Baricitinib Improves Bone Properties and Biomechanics in Patients With Rheumatoid Arthritis: Results of the Prospective Interventional BARE BONE Trial

 Circulation October 24, 2023 

Graft Failure After Coronary Artery Bypass Grafting and Its Association With Patient Characteristics and Clinical Events: A Pooled Individual Patient Data Analysis of Clinical Trials With Imaging Follow-Up

American College of Cardiology

Impact of Residual Inflammatory Risk in Patients Receiving Statin Therapy

International Study of Comparative Health Effectiveness With Medical and Invasive Approaches - ISCHEMIA

 Journal of Clinical Endocrinology & Metabolism

Age But Not Menopausal Status Is Linked to Lower Resting Energy Expenditure

  Neurology:

Movement Disorders in Patients With Genetic Developmental and Epileptic Encephalopathies

  Chest

Clinic vs Home Spirometry for Monitoring Lung Function in Patients With Asthma

Background

  The American Journal of Respiratory and Critical Care Medicine

Inflammatory Activity of Epithelial Stem Cell Variants from Cystic Fibrosis Lungs Is Not Resolved by CFTR Modulators

  Clinical Journal of American Society of Nephrology

Outcomes of Hospital-Acquired Hypernatremia

Fixed-Dose Combination Therapy for the Prevention of Cardiovascular Diseases in CKD: An Individual Participant Data Meta-Analysis

 Kidney International reports

Supporting Patient-Centered Pregnancy Counseling in Nephrology Care: A Semistructured Interview Study of Patients and Nephrologists

Hi, This Week in Medicine, we will be discussing

 New England Journal of Medicine

Sparsentan versus Irbesartan in Focal Segmental Glomerulosclerosis

 A Phase 2 Trial of Sibeprenlimab in Patients with IgA Nephropathy

 Thalidomide for Recurrent Bleeding Due to Small-Intestinal Angiodysplasia

 Pulsed Field or Conventional Thermal Ablation for Paroxysmal Atrial Fibrillation

Perioperative Durvalumab for Resectable Non–Small-Cell Lung Cancer

 Journal of Hypertension

Sedentary behavior and risk of cardiovascular disease and all-cause mortality in United States adults with hypertension

 Hypertension journal

Blood Pressure and Cardiovascular Disease Mortality Among US Adults: A Sex-Stratified Analysis, 1999–2019

 Journal of American Medical Association

Changes in Physician Electronic Health Record Use With the Expansion of Telemedicine

  Management for Opioid Use Disorder Treatment

 Annals of Internal Medicine

Chronotype, Unhealthy Lifestyle, and Diabetes Risk in Middle-Aged U.S. Women

 Suspected Bronchiectasis and Mortality in Adults With a History of Smoking Who Have Normal and Impaired Lung Function

 Journal of Clinical Oncology

Trastuzumab Deruxtecan in Patients With HER2-Mutant Metastatic Non–Small-Cell Lung Cancer: Primary Results From the Randomized, Phase II DESTINY-Lung02 Trial

  Hepatology

Effects of pegozafermin on the liver and on metabolic comorbidities in subjects with biopsy-confirmed nonalcoholic steatohepatitis

  Clinical microbiology and Infection

To evaluate the safety and efficacy of switching from intravenous (IV) to oral antimicrobial therapy in patients with Enterobacterales bacteraemia, after completion of 3–5 days of microbiologically active IV therapy.

 Journal of infectious Diseases

Sociodemographic Variables Can Guide Prioritized Testing Strategies for Epidemic Control in Resource-Limited Contexts

  Arthritis and Rheumatology

Rheumatoid Arthritis–Specific Autoimmunity in the Lung Before and at the Onset of Disease

Clinical and Biomarker Responses to BI 655064, an Antagonistic Anti-CD40 Antibody, in Patients With Active Lupus Nephritis: A Randomized, Double-Blind, Placebo-Controlled, Phase II Trial

 Circulation October 24, 2023 

Oral Anticoagulation Use and Left Atrial Appendage Occlusion in LAAOS III

American College of Cardiology

Lead Extraction and Mortality Among Patients With CIED Infection

China Tongxinluo Study for Myocardial Protection in Patients With Acute Myocardial Infarction

Relationship of Daily Step Counts to All-Cause Mortality and Cardiovascular Events

 Clinical Endocrinology & Metabolism

Thyroid Function Tests in Children and Adolescents With Trisomy 21: Definition of Syndrome-Specific Reference Ranges

  BLOOD ADVANCES

JAK2V617F mutation is highly prevalent in patients with ischemic stroke: a case-control study

 The American Journal of Respiratory and Critical Care Medicine

Improvement in Lung Clearance Index and Chest Computed Tomography Scores with Elexacaftor/Tezacaftor/Ivacaftor Treatment in People with Cystic Fibrosis Aged 12 Years and Older – The RECOVER Trial

Incorporating Effects of Time Accrued on the Waiting List into Lung Transplantation Survival Models

INTENSIVE CARE MEDICINE

Initiation of continuous renal replacement therapy versus intermittent hemodialysis in critically ill patients with severe acute kidney injury: a secondary analysis of STARRT-AKI trial

  JOURNAL OF AMERICAN SOCIETY OF MEDICINE, SURGERY

Primary Care Physician Follow-Up and 30-Day Readmission After Emergency General Surgery Admissions

Urology Journal

Acute Kidney Injury Within 90Days of Radical Cystectomy for Bladder Cancer: Incidence and Risk Factors

Hi, This Week in Medicine, we will be discussing

NEJM

 Patisiran Treatment in Patients with Transthyretin Cardiac Amyloidosis

Automated Insulin Delivery in Women with Pregnancy Complicated by Type 1 Diabetes

Phase 3 Trial of Nemolizumab in Patients with Prurigo Nodularis

Convalescent Plasma for Covid-19–Induced ARDS in Mechanically Ventilated Patients

JAMA

 Pharmacy e-Prescription Dispensing Before and After CancelRx Implementation

Defining Usual Oral Temperature Ranges in Outpatients Using an Unsupervised Learning Algorithm

Cardiac Arrest Survival at Emergency Medical Service Agencies in Catchment Areas With Primarily Black and Hispanic Populations

Annals of Internal Medicine

Association Between Vascular 18F-Fluorodeoxyglucose Uptake at Diagnosis and Change in Aortic Dimensions in Giant Cell Arteritis

Lancet

Intermediate endpoints as surrogates for outcomes in cancer immunotherapy: a systematic review and meta-analysis of phase 3 trials

Journal of Clinical Oncology

Allogeneic Hematopoietic Cell Transplantation Improves Outcome in Myelodysplastic Syndrome Across High-Risk Genetic Subgroups: Genetic Analysis of the Blood and Marrow Transplant Clinical Trials Network 1102 Study

Clinical Gastroenterology

Blood Test Increases Colorectal Cancer Screening in Persons Who Declined Colonoscopy and Fecal Immunochemical Test

Hepatology

Tropifexor plus cenicriviroc combination versus monotherapy in nonalcoholic steatohepatitis: Results from the phase 2b TANDEM study

Clinical Infectious Diseases

Sustained Viral Suppression With Dolutegravir Monotherapy Over 192 Weeks in Patients Starting Combination Antiretroviral Therapy During Primary Human Immunodeficiency Virus Infection (EARLY-SIMPLIFIED): A Randomized, Controlled, Multi-site, Noninferiority Trial 

Journal of infectious Diseases

Interference Between Enteric Viruses and Live-Attenuated Rotavirus Vaccine Virus in Journal of Clinical Rheumatology 

Clinical Characteristics and Prognostic Value of Ro52/SSA Antibodies in Idiopathic Inflammatory Myopathies

Arthritis and Rheumatology

Bone Loss in Inflammatory Rheumatic Musculoskeletal Disease Patients Treated With Low-Dose Glucocorticoids and Prevention by Anti-Osteoporosis Medications

Circulation

Blood Pressure and Oxygen Targets on Kidney Injury After Cardiac Arrest

ACC Latest-in-Cardiology 

Performance of the ACC/AHA Pooled Cohort Cardiovascular Risk Equations in Clinical Practice |

Journal of Clinical Endocrinology & Metabolism

Heart Rate Variability and Incident Type 2 Diabetes in General Population

New Findings on Presentation and Outcome of Patients With Adrenocortical Cancer: Results From a National Cohort Study

Neurology:

Randomized Trial Comparing Low- vs High-Dose IV Dexamethasone for Patients With Moderate to Severe Migraine

Chest

The Effect of Inhaled Corticosteroids on Pneumonia Risk in Patients With COPD-Bronchiectasis Overlap

Lifestyle, Genetic Susceptibility, and the Risk of Idiopathic Pulmonary Fibrosis

Cell-Free DNA Fragmentomes in the Diagnostic Evaluation of Patients With Symptoms Suggestive of Lung Cancer

 The American Journal of Respiratory and Critical Care Medicine

Sleep Apnea Physiological Burdens and Cardiovascular Morbidity and Mortality

  Clinical Journal of American Society of Nephrology

Anti-PLA2R Antibody Levels and Clinical Risk Factors for Treatment Nonresponse in Membranous Nephropathy

  Kidney International

Implications of Complete Proteinuria Remission at any Time in Focal Segmental Glomerulosclerosis: Sparsentan DUET Trial

Hi, This Week in Medicine, we will be discussing

NEJM

Improved Outcomes with Enzalutamide in Biochemically Recurrent Prostate Cancer

Optical Coherence Tomography–Guided versus Angiography-Guided PCI

OCT or Angiography Guidance for PCI in Complex Bifurcation Lesions

Trial of Vancomycin and Cefazolin as Surgical Prophylaxis in Arthroplasty

JAMA

Cefepime vs Piperacillin-Tazobactam in Adults Hospitalized With Acute Infection

The ACORN Randomized Clinical Trial

Endovascular Aneurysm Repair Devices as a Use Case for Postmarketing Surveillance of Medical Devices

Changes in the Use of Long-Term Medications Following Incident Dementia Diagnosis

Late Mortality After COVID-19 Infection Among US Veterans vs Risk-Matched ComparatorsA 2-Year Cohort Analysis

Annals of Internal Medicine

Blood Pressure Level in Late Adolescence and Risk for Cardiovascular Events

Atrial Fibrillation Recurrence in Patients With Transient New-Onset Atrial Fibrillation Detected During Hospitalization for Noncardiac Surgery or Medical Illness

Lancet

Immune response after pig-to-human kidney xenotransplantation: a multimodal phenotyping study

Journal of Clinical Oncology

Cluster Randomized Pragmatic Clinical Trial Testing Behavioral Economic Implementation Strategies to Improve Tobacco Treatment for Patients With Cancer Who Smoke

Hepatology

Predicting liver-related events in NAFLD: A predictive model

Clinical Infectious Diseases

Incidence of Hypertension and Blood Pressure Changes in Persons With Human Immunodeficiency Virus at High Risk for Cardiovascular Disease Switching From Boosted Protease Inhibitors to Dolutegravir

Journal of infectious Diseases

Bronchiolitis, Regardless of Its Etiology and Severity, Is Associated With Increased Risk of Asthma: A Population-Based Study 

Journal of Clinical Rheumatology 

Does the Type of Failure and the Choice of the Second Biologic Influence Response and Persistence on Medication in Rheumatoid Arthritis?

Arthritis and Rheumatology

The 2022 EULAR/ACR Points to Consider at the Early Stages of Diagnosis and Management of Suspected Haemophagocytic Lymphohistiocytosis/Macrophage Activation Syndrome

Circulation

Improved Cardiac Function in Postischemic Rats Using an Optimized Cardiac Reprogramming Cocktail Delivered in a Single Novel Adeno-Associated Virus

ACC: LATEST IN CARDIOLOGY  

Benefits and Drawbacks of Vegetarian and Vegan Diets: Key Points

Journal of Clinical Endocrinology & Metabolism

Visit to Visit Hemoglobin A1c Variation and Long-term Risk of Major Adverse Limb Events in Patients With Type 2 Diabetes 

Bone Marrow Adiposity and Fragility Fractures in Postmenopausal Women: The ADIMOS Case-Control Study

Neurology:

Association Between Socioeconomic Factors, Race, and Use of a Specialty Memory Clinic

Chest

Effect of Hypertonic Saline on Lung Function as Add-on Treatment in People With Cystic Fibrosis Receiving Dornase Alfa

Noninvasive Oxygenation Strategies in Adult Patients With Acute Hypoxemic Respiratory Failure

Observation, Aspiration, or Tube Thoracostomy for Primary Spontaneous Pneumothorax

The American Journal of Respiratory and Critical Care Medicine

A Polygenic Risk Score for Idiopathic Pulmonary Fibrosis and Interstitial Lung Abnormalities

Clinical Journal of American Society of Nephrology

Early Risk Stratification for Natural Disease Course in Fabry Patients Using Plasma Globotriaosylsphingosine Levels

 Kidney International

Patient Preferences for the Management of Gastrointestinal Symptoms in Kidney Transplantation: a Discrete Choice Experiment

Hi, This Week in Medicine, we will be discussing

 NEJM

 Adjunctive Dexamethasone for Tuberculous Meningitis in HIV-Positive Adults

 Timing of Complete Revascularization with Multivessel PCI for Myocardial Infarction

Catheter Ablation in End-Stage Heart Failure with Atrial Fibrillation

Ceftobiprole for Treatment of Complicated Staphylococcus aureus Bacteremia

JAMA

 Effects of Cuff Size on the Accuracy of Blood Pressure ReadingsThe Cuff(SZ) Randomized Crossover Trial

Association of Intensive Lifestyle Intervention for Type 2 Diabetes With Labor Market Outcomes

Comparison of Particulate Air Pollution From Different Emission Sources and Incident Dementia in the US

Annals of Internal Medicine

Risk for Congenital Anomalies in Children Conceived With Medically Assisted Fertility Treatment

Implications of the Use of Artificial Intelligence Predictive Models in Health Care Settings

 BMJ

Interactive effects of ambient fine particulate matter and ozone on daily mortality in 372 cities

Lancet

Adaptive versus conventional cardiac resynchronisation therapy in patients with heart failure (AdaptResponse): a global, prospective, randomised controlled trial

Journal of Clinical Oncology

Eltrombopag for Low-Risk Myelodysplastic Syndromes With Thrombocytopenia: Interim Results of a Phase II, Randomized, Placebo-Controlled Clinical Trial (EQOL-MDS)

Hepatology

Lactulose therapy for patients with cirrhosis, portal hypertension, and poor patient-reported outcomes: The Mi-Kristal trial

Blood

Prevalence and significance of DDX41 gene variants in the general population

Clinical Infectious Diseases

Current Epidemiology and Clinical Features of Cryptococcus Infection in Patients Without Human Immunodeficiency Virus

Journal of infectious Diseases

JC Polyomavirus Modifies the Expression of Human microRNAs in Progressive Multifocal Leukoencephalopathy Brain

Journal of Clinical Rheumatology 

The Effect of Clinical and Genetic Variables of Familial Mediterranean Fever Patients: Real Life Data

Arthritis and Rheumatology

The 2023 ACR/EULAR Classification Criteria for Calcium Pyrophosphate Deposition Disease

Circulation

Cost-Effectiveness of Vericiguat in Patients With Heart Failure With Reduced Ejection Fraction: The VICTORIA Randomized Clinical Trial

American college of cardiology: /Latest-in-Cardiology 

Machine Learning Approaches in Primary Mitral Regurgitation

Journal of Clinical Endocrinology & Metabolism

Testicular Dysfunction in 47,XXY Boys: When It All Begins. A Semilongitudinal Study

Sex-specific Association Between Adipose Tissue Inflammation and Vascular and Metabolic Complications of Obesity 

Neurology:

Association of Plasma Biomarkers of Alzheimer Disease With Cognition and Medical Comorbidities in a Biracial Cohort

Chest

Open-Label Trial of Amikacin Liposome Inhalation Suspension in Mycobacterium abscessus Lung Disease

Lower vs Higher Fluid Volumes in Adult Patients With Sepsis

The Effects of Exercise Training in Patients With Persistent Dyspnea Following Pulmonary Embolism

The American Journal of Respiratory and Critical Care Medicine

Conservative versus Liberal Oxygenation Targets in Intensive Care Unit Patients (ICONIC): A Randomized Clinical Trial

Clinical and Translational Gastroenterology 

Lactulose versus polyethylene glycol for bowel preparation: a single-center, prospective, randomized controlled study based on the BMI

Clinical Journal of American Society of Nephrology

Renin–Angiotensin–Aldosterone System Blockade after AKI with or without Recovery among US Veterans with Diabetic Kidney Disease

Kidney International

A cohort study found a high risk of end-stage kidney disease associated with acromegaly