Join Dr Nick Pimlott for this episode of the CFP Podcast as he interviews Alex Crawley and Amy Soubolsky from the Rx Files Academic Detailing Program in Saskatchewan about the management of difficult-to-treat depression in primary care. The interview is based on an article published in the November issue of the journal entitled “Thoughtful prescribing for difficult to treat depression”. Mr. Crawley and Ms. Soubolsky are co-authors of the article with their colleague Jessica Visentin. Together they discuss a case-based careful step wise approach to this challenging area of clinical practice.