Intravenous thrombolysis (IVT) and endovascular thrombectomy (EVT) both improve outcomes for patients with acute ischemic stroke. Jeffrey L. Saver, MD, director of UCLA’s Comprehensive Stroke and Vascular Neurology Program and a JAMA Associate Editor, discusses 2 randomized trials comparing outcomes for stroke patients treated with IVT prior to EVT vs EVT alone. Related Article:  Intravenous Thrombolysis Before Endovascular Thrombectomy for Acute Ischemic Stroke

Thrombolysis Before Thrombectomy for Stroke

Interviews with leading researchers and thinkers in health care about practice-changing research, innovations, and the most pressing issues facing medicine and health care today from JAMA, the Journal of the American Medical Association.

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Can a new ECG finding identify individuals at risk for dying suddenly? Jason D. Roberts, MD, of McMaster University joins JAMA Associate Editor Gregory M. Marcus, MD, MAS, to discuss A Clinical Diagnostic Test for Calcium Release Deficiency Syndrome (CRDS). CRDS is a recently described cause of sudden arrhythmic death. Until now, no clinical test has existed to identify those with the disease.  Related Content:  A Clinical Diagnostic Test for Calcium Release Deficiency Syndrome The First Clinical Test for Calcium Release Deficiency Syndrome? 

Sudden Death, Calcium Release Deficiency Syndrome, and a New ECG Finding

Joel M. Dulhunty, MD, PhD, Royal Brisbane and Women’s Hospital, and Jason A. Roberts, BPharm, PhD, University of Queensland Centre for Clinical Research, join JAMA Deputy Editor Preeti Malani, MD, MSJ, to discuss the BLING trial that assessed continuous vs intermittent β-lactam antibiotic infusions in patients with sepsis or septic shock.  Related Content:  Continuous vs Intermittent β-Lactam Antibiotic Infusions in Critically Ill Patients With Sepsis Prolonged vs Intermittent Infusions of β-Lactam Antibiotics in Adults With Sepsis or Septic Shock 

Continuous vs Intermittent β-Lactam Antibiotic Infusions in Patients With Sepsis

Randomized clinical trials (RCTs) frequently fail to generate knowledge relevant to practice, while practice patterns are frequently unsupported by RCT evidence. Derek C. Angus, MD, MPH, of the University of Pittsburgh, joins JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, to discuss The Integration of Clinical Trials With the Practice of Medicine: Repairing a House Divided.  Related Content:  The Integration of Clinical Trials With the Practice of Medicine 

Integrating Clinical Trials With the Practice of Medicine

Forced nitrogen inhalation was used by the state of Alabama to execute Kenneth Smith on January 25, 2024. Some politicians, attorneys general, and health care practitioners support its use for capital punishment in the US. Philip E. Bickler, MD, PhD, and Michael S. Lipnick, MD, discuss the evidence indicating that forced nitrogen inhalation is inhumane with JAMA Executive Editor Gregory Curfman, MD.  Related Content:  Evidence Against Use of Nitrogen for the Death Penalty 

Evidence Against Nitrogen’s Use for the Death Penalty

Guidelines call for better evidence on the health outcomes after living kidney donation. Author Amit X. Garg, MD, PhD, London Health Sciences Centre, and editorialist Elizabeth C. Lorenz, MD, Baylor College of Medicine, discuss a new study that compares the risks of hypertension and other health outcomes in living kidney donors, with JAMA Associate Editor Wolfgang Winkelmayer, MD, ScD.  Related Content:  Hypertension and Kidney Function After Living Kidney Donation Prospectively Examining Outcomes After Living Kidney Donation Kidney Transplant Outcomes From Deceased Donors Who Received Dialysis Expanding the Overton Window in Deceased Kidney Donor Eligibility—Enough to Make a Difference? 

Thrombolysis Before Thrombectomy for Stroke

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