In this episode of Run the List, Joyce Zhou (host) and Blake Smith (case presenter) talk with Dr. Jean Connors, a hematologist at Brigham and Women’s Hospital and Dana Farber Cancer Institute, about the causes of thrombophilia (congenital and acquired) and its management in the acute care setting. We learn about common risk factors and how these can be both additive and synergistic with inherited causes of thrombophilia. The episode closes with Dr. Connors’ discussion of both when to order lab tests and how to interpret them in the setting of VTE, in addition to important clinical pearls to consider with any case of known or suspected thrombophilia.