Invisible illnesses shape millions of lives, yet most patients spend years in the system without answers. Dr. David Clarke has spent his career at the intersection of internal medicine, psychology, and mind-body research. His mission is clear. Help clinicians recognize when symptoms are driven by the nervous system rather than structural disease. Help patients finally feel seen. And give the medical community a framework to reduce unnecessary testing while improving outcomes.

In this episode he explains how the brain generates real physical symptoms under stress, trauma, and emotional overload. He walks through clinical red flags that differentiate structural disease from functional conditions. He shares stories of patients who suffered for years before receiving the right diagnosis. Dr. Bonta and Dr. Clarke explore why invisible illnesses are often missed in rushed systems. They dig into tools clinicians can use to validate symptoms without over pathologizing them. They highlight communication strategies that restore trust. They also discuss prevention, early detection, and the growing evidence supporting mind-body approaches.

The conversation is practical. Evidence based. Deeply human. Dr. Clarke shows how clinicians can uncover hidden drivers of symptoms and give patients a path to recovery even when imaging and lab work are normal. This episode is designed for anyone who wants to understand the science and psychology behind medically unexplained symptoms and how to improve care for this underserved population.

David Clarke, MD's Website : https://www.symptomatic.me/

Episode Takeaway 

1. Neuroplastic Symptoms: Real physical sensations created by the brain that can improve with the right approach.
2. Invisible Illnesses: Often missed because standard training focuses on structural disease, not functional mechanisms.
3. Brain Body Pathways: Stress and trauma can activate neural circuits that generate chronic pain and gut symptoms.
4. Diagnostic Clarity: Red flags help distinguish functional illness from conditions that need imaging or procedures.
5. Validation Matters: Patients recover faster when clinicians acknowledge symptoms without dismissing them.
6. Communication Skills: Asking the right questions uncovers hidden emotional drivers behind persistent symptoms.
7. Prevention Tools: Early recognition of neuroplastic patterns reduces unnecessary testing and specialist referrals.
8. Hope in Recovery: Most patients improve once they learn how the nervous system produces their symptoms.

Episode timestamps 

02:46 – Why invisible illnesses elude standard medical training
06:13 – How the nervous system produces real physical symptoms
10:34 – Red flags that separate structural disease from functional illness
14:51 – Communication strategies that validate patient symptoms
19:30 – Trauma, stress and the hidden drivers of chronic symptoms
24:42 – Clinical cases that shifted Dr. Clarke’s diagnostic approach
30:04 – Tools clinicians can use to reduce unnecessary testing
35:57 – Preventing invisible illness through early recognition and education

DISCLAMER >>>>>>    The Ditch Lab Coat podcast serves solely for general informational purposes and does not serve as a substitute for professional medical services such as medicine or nursing. It does not establish a doctor/patient relationship, and the use of information from the podcast or linked materials is at the user's own risk. The content does not aim to replace professional medical advice, diagnosis, or treatment, and users should promptly seek guidance from healthcare professionals for any medical conditions.  

 >>>>>> The expressed opinions belong solely to the hosts and guests, and they do not necessarily reflect the views or opinions of the Hospitals, Clinics, Universities, or any other organization associated with the host or guests.   

 Disclosures: Ditch The Lab Coat podcast is produced by (soundsdebatable.com) and is independent of Dr. Bonta's teaching and research roles at McMaster University, Temerty Faculty of Medicine and Queens University.