In this compelling episode of the HF Beat, join hosts Michael Beasley, MD and Priya Umapathi, MD and an esteemed panel of experts, including Dr. Eileen Hsich, Dr. Anu Lala, and Dr. Ilan Goldenberg, as they delve into the nuanced world of sex differences in heart failure. This conversation spans three key topics: identifying traditional and sex-specific risk factors for heart failure, addressing disparities in diagnosis and treatment, and exploring the implications of these differences on therapeutic responses and device-based interventions. Highlights include discussions on under diagnosis in women due to natriuretic peptide thresholds, CRT’s heightened benefits in women with non-ischemic cardiomyopathy, and the urgent need for inclusive clinical trials. With actionable insights and cutting-edge research, this episode equips heart failure clinicians with essential knowledge to better serve our heart failure patient population. Tune in to explore how advancing sex-specific research can transform heart failure care for all.