In this World Shared Practice Forum Podcast, Drs. Adrienne Randolph and Aaron Bodansky explore the groundbreaking research findings that uncover the pathophysiological mechanism behind multisystem inflammatory syndrome in children (MIS-C). These findings shed light on the characteristic immune response of patients who develop MIS-C, and provide insight into the development of post-infectious auto-immune disease phenotypes.

LEARNING OBJECTIVES

- Describe the pathophysiology of MIS-C, including the clinical features and molecular immune response

- Describe the immune dysregulation that results in MIS-C, including the role of autoantibodies and T-cell responses

- Identify the potential connections between SARS-CoV-2 infection and the development of autoimmune responses

- Recognize the implications of the study findings for other related conditions such as long COVID and sepsis

AUTHORS

Adrienne Randolph, MD, MSc

Senior Associate in Critical Care Medicine, Department of Anesthesiology, Critical Care and Pain Medicine

Boston Children's Hospital

Professor of Anaesthesia and Pediatrics

Harvard Medical School

Aaron Bodansky, MD

Assistant Professor

Pediatric Critical Care

University of California, San Francisco School of Medicine

DATES

Initial publication: September 24, 2024.

ARTICLES REFERENCED

Bodansky A, Mettelman RC, Sabatino JJ Jr, et al. Molecular mimicry in multisystem inflammatory syndrome in children. Nature. 2024;632(8025):622-629. doi:10.1038/s41586-024-07722-4.

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CITATION

Randolph AG, Bodansky A, Burns JP. Unveiling MIS-C's Immune Response: Molecular Mimicry. 09/2024. OPENPediatrics. https://soundcloud.com/openpediatrics/unveiling-mis-cs-immune-response-molecular-mimicry-by-a-randolph-and-a-bodansky-openpediatrics