In this week's episode we'll learn about refining risk stratification in T-cell acute lymphoblastic leukemia, or ALL. After that, we'll discuss a novel gene therapy approach in severe alpha-thalassemia. Investigators describe an innovative mouse model and an effective gene therapy approach, renewing prospects for the development of novel strategies to treat this disease. Finally, we'll hear about how genomic profiling has helped identify subgroups associated with distinct clinical phenotypes and outcomes in the molecular taxonomy of myelodysplastic syndromes, or MDS.

Featured Articles 

• NGS-based stratification refines the risk stratification in T-ALL and identifies a very-high-risk subgroup of
  patients
• Use of HSC-targeted LNP to generate a mouse model of lethal α-thalassemia and treatment via lentiviral
  gene therapy
• Molecular taxonomy of myelodysplastic syndromes and its clinical implications