How can smart people enjoy a game about a naked boy crying at poop? Binding of Isaac is one of the most chaotic, labyrinthine, and complex games we've ever put multiple hundreds of hours into. Inspired by Legend of Zelda and Rogue, Binding of Isaac sees you grabbing dozens of game-changing items, building a unique Isaac, and descending deeper into the basement than you ever imagined. Gary is joined by his Everything to Guppy co-host, Will Hughes, to break down what makes Binding of Isaac an easy entry in the video game hall of fame.