In North Carolina presenter Tim Samuel finds the contradictions and cultural clashes that are playing out across the US – with men often in the middle of the fallout. Heading through the Appalachian mountains – where traditional blue-collar jobs have collapsed - he sees the social ravages of opioid addiction. Indeed, a doctor reveals that for the first time in generations male mortality is starting to move in the wrong direction; we are in the midst of a man crisis, he says.