As the initial doses of COVID-19 vaccines are deployed throughout the world, there is a continued debate on which groups should be next in line for vaccination. This episode features an expert panel discussing the rationale and ethical dilemmas of the COVID-19 vaccine distribution plan. (Originally recorded January 7, 2021) Moderator: Alice Gallo De Moraes, MD. Panelists: Rick Bright, PhD; Nathaniel Hupert, MD, MPH; and Ryan Maves, MD, FCCP. For more tools to help in the fight against COVID-19, visit CHEST’s COVID-19 Resource Center at chestnet.org/COVID19.