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Days of our Lives sees significant cast changes are anticipated. Rachel Blake, portrayed by Rosalyn Gentle, is set to exit the show after she was arrested for holding Ava Vitali (Tamara Braun) and Rafe hostage Hernandez (Galen Gering). Emily O'Brien is confirmed to make a comeback in dual roles - Teresa and Gwen. While Teresa's return seems imminent due to her recent release from prison, Gwen's appearance will bring some exciting new information, particularly about her sister Abigail Deveraux's (AnnaLynne McCord) whereabouts on the NBC Peacock soap opera.

DOOL will see soap veteran Michael Dietz will also make a brief appearance in Salem, possibly as the doctor attending to EJ DiMera's (Dan Feuerriegel) gunshot wound. Bo Brady (Peter Reckell) and Hope Brady (Kristian Alfonso) are slated to return in May 2025 for a brief storyline before making an exit. Other anticipated returns include characters such as Sami Brady (Alison Sweeney), Rex Brady (Kyle Lowder), Ciara Brady (Victoria Konefal), Will Horton (Chandler Massey), Jack Deveraux (Matthew Ashford) and Jennifer Deveraux (Melissa Reeves), Vivian Alamain (Louise Sorel), and Eric Brady (Greg Vaughan). Alison Sweeney's character, Sami, is set to return amidst drama involving EJ and Johnny DiMera (Carson Boatman). Finally, Sophia Choi's (Rachel Boyd) character will exit the show once her baby with Tate Black (Leo Howard) is born and presumably adopted out.

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