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GLP-1 drugs such as Ozempic have become some of the world's most-wanted medicines, but soaring demand has also turned them into a stress test for the global drug system. On this episode of Why It Matters, Gabrielle Sierra and CFR Senior Fellow Prashant Yadav trace how the GLP-1 trend led to shortages, a booming gray market, and steep price gaps driven by patent laws that vary across borders.
Host:
Gabrielle Sierra, Director of Podcasting, Council on Foreign Relations (CFR)
Guest:
Prashant Yadav, Senior Fellow for Global Health, Council on Foreign Relations (CFR)
Read More:
“6 Facts About Obesity and Weight Loss Drugs In the U.S.,” Pew Research Center
“The Expanding Benefits of GLP-1 Medicines,” Cell Reports Medicine
“Obesity Drugs Are Scaling Fast,” Morgan Stanley
“FDA’s Concerns with Unapproved GLP-1 Drugs Used for Weight Loss,” U.S. Food and Drug Administration (FDA)
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Why It Matters is a production of the Council on Foreign Relations. The opinions expressed on the show are solely those of the host and guests, not of the Council, which takes no institutional positions on matters of policy.
This episode explores how drones, cell phones, and other widely-available intelligence tools are turning civilians and aid workers into frontline witnesses—documenting war in real time, guiding humanitarian aid, and helping build evidence that could power future war crimes cases.
Host:
Gabrielle Sierra, Director of Podcasting, Council on Foreign Relations (CFR)
Guest:
Anthony Vinci, Cofounder and CEO, Vico; Adjunct Senior Fellow, Technology and National Security Program, Center for a New American Security (CNAS)
Sam Vigersky, International Affairs Fellow, Council on Foreign Relations (CFR)
We discuss:
Read more:
Anthony Vinci, The Fourth Intelligence Revolution
Sam Vigersky, “Beyond Conventional Aid: Institutionalizing Public-Private Partnership in Ukraine’s Humanitarian Response,” CFR.org
“Counting the Dead,” Human Rights Watch
“Listen, Run, Hide: How Russia Uses Quadcopter Drones to Hunt and Kill Civilians in Kherson, Ukraine,” Human Rights Watch
“UN Commission Concludes that Russian Armed Forces’ Drone Attacks Against Civilians in Kherson Province Amount to Crimes Against Humanity of Murder,” United Nations Human Rights Office of the High Commissioner
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Why It Matters is a production of the Council on Foreign Relations. The opinions expressed on the show are solely those of the host and guests, not of the Council, which takes no institutional positions on matters of policy.
This episode traces one young woman's journey home to a new kind of war—and Ukraine’s fight for survival.
Host:
Gabrielle Sierra, Director of Podcasting, Council on Foreign Relations (CFR)
Guest:
Catarina Buchatskiy, Co-Founder & Director of Analytics, Snake Island Institute
We discuss:
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Why It Matters is a production of the Council on Foreign Relations. The opinions expressed on the show are solely those of the host and guests, not of the Council, which takes no institutional positions on matters of policy.
This episode outlines the global network sustaining both sides of the war in Ukraine, with NATO allies on one side and Russia with backing from China, Iran, and North Korea on the other, and how the limits and tensions within these alliances are shaping the war’s next phase and raising broader global security risks.
Host:
Gabrielle Sierra, Director of Podcasting, Council on Foreign Relations (CFR)
Guests:
Liana Fix, Senior Fellow for Europe, Council on Foreign Relations (CFR)
Joseph Torigian, Senior Fellow for Asia Studies, Council on Foreign Relations (CFR)
We discuss:
Read More:
Liana Fix, “Defending Europe if Russia Steps Out of the Gray Zone,” CFR.org
Liana Fix, Heidi E. Crebo-Rediker, Thomas Graham, Paul B. Stares, and Sam Vigersky, “Securing Ukraine’s Future: Adapting to New Realities After Four Years of War,” CFR.org
Joseph Torigian, “Xi Jinping’s Russian Lessons,” Foreign Affairs
Clara Fong and Lindsay Maizland, “China and Russia: Exploring Ties Between Two Authoritarian Powers”
Anya Konstantinovsky, “China, Russia, and Ukraine: December 2024”
Molly Carlough and James Kennedy, “How North Korea Has Bolstered Russia’s War in Ukraine”
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Why It Matters is a production of the Council on Foreign Relations. The opinions expressed on the show are solely those of the host and guests, not of the Council, which takes no institutional positions on matters of policy.
This episode explores how the emergence of drone warfare and innovation under fire is transforming power and forcing nations to rethink strategy and military capacity.
Host:
Guests:
Michael C. Horowitz, Senior Fellow for Technology and Innovation, Council on Foreign Relations (CFR)
Erin D. Dumbacher, Stanton Nuclear Security Senior Fellow, Council on Foreign Relations (CFR)
We discuss:
Read More:
Securing Ukraine’s Future, CFR
Michael C. Horowitz and Lauren Kahn, “Military AI Adoption Is Outpacing Global Cooperation,” CFR.org
Michael Horowitz, “What Drones Can—and Cannot—Do on the Battlefield,” Foreign Affairs
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Why It Matters is a production of the Council on Foreign Relations. The opinions expressed on the show are solely those of the host and guests, not of the Council, which takes no institutional positions on matters of policy.
As 2025 draws to a close, U.S. foreign policy stands at an inflection point. Under the second Trump administration, traditional alliances have been tested, a hard-edged national security strategy has been rolled out, and for the first time, CFR’s annual Preventive Priorities Survey has ranked a military conflict with Venezuela as a top threat facing the U.S. in 2026.
Whether these and other flashpoints erupt next year will hinge on how world leaders manage mounting pressures, both at home and abroad.
Read the full 2026 Preventive Priorities Survey.
Featured Guest:
Paul B. Stares (General John W. Vessey Senior Fellow for Conflict Prevention and Director of the Center for Preventive Action)
Why It Matters is a production of the Council on Foreign Relations. The opinions expressed on the show are solely those of the guests, not of CFR, which takes no institutional positions on matters of policy.
The unprecedented trade policies since the beginning of this year, driven largely by the Donald Trump administration’s pro-tariff agenda, have propelled the United States into uncertain and rocky territory. When it comes to our trading partners, the potential damage to U.S. alliances has left economists and policymakers in Washington questioning what’s next. Where do experts foresee U.S. trade policy heading?
This season, Why It Matters is taking you through the ins and outs of trade. In this season finale, CFR’s Michael Froman and Shannon K. O’Neil tackle your biggest questions about what’s at stake and what’s next for U.S. trade policy.
Featured Guests:
Michael Froman (President of the Council on Foreign Relations)
Shannon K. O’Neil (Senior Vice President, Director of Studies, and Maurice R. Greenberg Chair, CFR)
For an episode transcript and show notes, visit us at https://www.cfr.org/podcasts/wim/where-does-trade-go-here
Is having a trade deficit necessarily a bad thing? Many experts argue that the U.S. trade deficit is largely good for our economy. It allows Americans to enjoy a wider variety of cheap goods, attracts foreign investment, and reflects the strength of the U.S. dollar. Others believe it’s a warning sign that we’re relying too much on imports, hurting American jobs, and racking up debt owed to other countries.
This season, Why It Matters is taking you through the ins and outs of trade. In this episode, we unpack the trade deficit. What is it and why has it become a primary focus of the second Trump administration?
Featured Guests:
Brad W. Setser (The Whitney Shepardson Senior Fellow specializing in global trade and capital flows, financial vulnerability analysis, and sovereign debt restructuring, CFR)
For an episode transcript and show notes, visit us at https://www.cfr.org/podcasts/wim/mind-trade-gap
Host Gabrielle Sierra and podcast guests Johanna Mendelson Forman and Matthew Costello discuss food diplomacy, share stories from White House state dinners, and unpack how food has helped to create lasting international partnerships.
This taping was originally recorded on April 17, 2025.
Featured Guests
Johanna Mendelson Forman (Distinguished Fellow at the Stimson Center, Adjunct Professor at American University’s School of International Service)
What role does the president have when it comes to making trade deals? In this episode, we dig into the expansive powers of the U.S. president when it comes to trade. From unilateral authority to congressional oversight, we unpack who truly calls the shots when the U.S. negotiates trade agreements.
Featured Guest:
Inu Manak (Fellow for trade policy at the Council on Foreign Relations)
For an episode transcript and show notes, visit us at https://www.cfr.org/podcasts/wim/trade-agreements-deal-or-no-deal
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