In this original What the Dementia episode, we discuss the recently fully approved drug Leqembi (also known as Lecanemab) by the FDA for the treatment of Mild Cognitive Impairment (MCI) and Mild Alzheimer's disease. The episode focuses on providing an understanding of what Leqembi is and what it is not, and offers an alternative perspective to help caregivers make informed decisions.

This episode will cover:

— What Leqembi is and its target audience

— The drug's unique approach to targeting beta-amyloid

— Efficacy claims and study challenges

— Side effects and risks associated with Leqembi

— Cost and potential impact on Medicare

— Gender and genetic factors influencing drug effectiveness

— The importance of considering individual goals and quality of life when evaluating treatment options for dementia.

References |

Clinical Dementia Rating Scale: https://knightadrc.wustl.edu/wp-content/uploads/2021/06/CDR-Table.pdf

Original study: https://www.nejm.org/doi/full/10.1056/NEJMoa2212948

https://www.accessdata.fda.gov/drugsatfda_docs/label/2023/761269s001lbl.pdf

https://www.eisai.com/news/2023/news202302.html

https://journals.lww.com/neurotodayonline/blog/breakingnews/pages/post.aspx?PostID=1356&utm_source=twitter&utm_medium=organic+social

https://journals.lww.com/neurotodayonline/Fulltext/2023/04200/APOE_Genotyping_Will_Play_a_Major_Role_in.1.aspx

https://news.usc.edu/88618/men-with-alzheimers-gene-at-risk-of-brain-bleeding-study-finds/

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