Manolis Kellis is a computational biologist at MIT. Please support this podcast by checking out our sponsors:

- SEMrush: https://www.semrush.com/partner/lex/ to get a free month of Guru

- Pessimists Archive: https://pessimists.co/

- Eight Sleep: https://www.eightsleep.com/lex and use code LEX to get $200 off

- BetterHelp: https://betterhelp.com/lex to get 10% off

EPISODE LINKS:

Manolis Website: http://web.mit.edu/manoli/

Manolis Twitter: https://twitter.com/manoliskellis

Manolis YouTube: https://www.youtube.com/channel/UCkKlJ5LHrE3C7fgbnPA5DGA

Manolis Wikipedia: https://en.wikipedia.org/wiki/Manolis_Kellis

PODCAST INFO:

Podcast website: https://lexfridman.com/podcast

Apple Podcasts: https://apple.co/2lwqZIr

Spotify: https://spoti.fi/2nEwCF8

RSS: https://lexfridman.com/feed/podcast/

YouTube Full Episodes: https://youtube.com/lexfridman

YouTube Clips: https://youtube.com/lexclips

SUPPORT & CONNECT:

- Check out the sponsors above, it's the best way to support this podcast

- Support on Patreon: https://www.patreon.com/lexfridman

- Twitter: https://twitter.com/lexfridman

- Instagram: https://www.instagram.com/lexfridman

- LinkedIn: https://www.linkedin.com/in/lexfridman

- Facebook: https://www.facebook.com/LexFridmanPage

- Medium: https://medium.com/@lexfridman

OUTLINE:

Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time.

00:00 - Introduction

08:05 - Molecular basis for human disease

32:04 - Deadliest diseases

37:47 - Genetic component of diseases

46:38 - Genetic understanding of disease

1:02:25 - Unified theory of human disease

1:08:26 - Genome circuitry

1:33:29 - CRISPR

1:45:06 - Mitochondria

1:53:10 - Future of biology research

2:22:46 - The genetic circuitry of disease