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Today, we had the pleasure of having Melanie Sisk on the show to demystify the complex world of emerging endocrine therapies, often referred to as the "alphabet soup" of treatments. Melanie provided clarity on the different classes of drugs and how they interact with tumors, particularly focusing on those that target estrogen receptors.

We discussed:

• SERMs (Selective Estrogen Receptor Modulators): These drugs, like tamoxifen, block the growth of cancer cells by competing with estrogen receptors.
• SERDs (Selective Estrogen Receptor Down Regulators/Degraders): Drugs like Fluvestrant work by degrading estrogen receptors.
• SERANs (Complete Estrogen Receptor Antagonists): These block both pathways of estrogen, offering a complete blockade.
• PROTACs: A newer class that targets specific proteins, such as the estrogen receptor, to inhibit cancer growth.

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