Sam Harris speaks with Shamil Chandaria about how the brain constructs a vision of the self and the world. They discuss the brain from first principles; Bayesian inference; hierarchical predictive processing; the construction of vision; psychedelics and neuroplasticity; beliefs and prior probabilities; the interaction between psychedelics and meditation; the risks and benefits of psychedelics; Sam’s recent experience with MDMA; non-duality; love, gratitude, and bliss; the self model; the Buddhist concept of emptiness; human flourishing; effective altruism; and other topics.

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Learning how to train your mind is the single greatest investment you can make in life. That’s why Sam Harris created the Waking Up app. From rational mindfulness practice to lessons on some of life’s most important topics, join Sam as he demystifies the practice of meditation and explores the theory behind it.