Sign up to save your podcasts
Or
Share #324 ‒ Metabolism, energy balance, and aging: How diet, calorie restriction, and macronutrients influence longevity and metabolic health | Eric Ravussin, Ph.D.
Share to email
Share to Facebook
Share to X
Share to email
Share to Facebook
Share to X
Or
#324 ‒ Metabolism, energy balance, and aging: How diet, calorie restriction, and macronutrients influence longevity and metabolic health | Eric Ravussin, Ph.D.
View the Show Notes Page for This Episode
Become a Member to Receive Exclusive Content
Sign Up to Receive Peter’s Weekly Newsletter
Eric Ravussin is a world-renowned expert on obesity, metabolism, and aging whose pioneering research has shaped much of what we understand today about energy balance and caloric restriction. In this episode, Eric shares insights from his cutting-edge work on energy expenditure—a critical factor in understanding how our bodies regulate weight and appetite. He discusses methods for measuring energy output, energy balance, food intake, and appetite regulation, and explores key studies on macronutrient manipulation. Eric then delves into the CALERIE study on caloric restriction, highlighting insights related to biomarkers of both primary and secondary aging. The conversation also covers the potential of GLP-1 agonists to replicate these effects and looks ahead to how AI and technology could transform metabolic research in the coming years.
We discuss:
- Eric’s background and current work metabolism and measuring energy expenditure [3:00];
- The science behind metabolic chambers for measuring energy expenditure, and the complexities of indirect and direct calorimetry [8:00];
- The body's regulatory systems for maintaining energy balance and the primary influence of energy intake on body weight [18:30];
- The epidemic of obesity and a discussion of resting metabolic rate [24:45];
- The impact of exercise, appetite, gut hormones, and eating patterns on weight regulation [28:45];
- Experiments looking at how macronutrient composition affects energy expenditure [38:45];
- The challenges of studying diet in real-life settings, the potential of personalized nutrition, and how public health policy could play a role in guiding nutritional habits [51:00];
- The importance of protein in the diet, the limitations of dietary data collection, and how AI could potentially transform nutrition science [1:08:15];
- How Eric’s interest in caloric restriction (CR) began with Biosphere 2, metabolic efficiency's role in aging, and goals of the CALERIE study [1:15:15];
- The CALERIE study: exploring the real-world impact of caloric restriction [1:28:00];
- Notable findings from the CALERIE study after two years: sustained weight loss, participant retention, and more [1:40:00];
- The effect of caloric restriction on the hallmarks of aging [1:47:00];
- The challenge of applying CR to the general population, the potential of drugs and exercise to mimic the effects of CR [1:55:45];
- Upcoming study comparing caloric restriction to time-restricting eating, and Peter’s takeaways from the discussion [2:02:45]; and
- More.
Connect With Peter on Twitter, Instagram, Facebook and YouTube
View all episodes
By Peter Attia, MD
4.7
71647,164 ratings
View the Show Notes Page for This Episode
Become a Member to Receive Exclusive Content
Sign Up to Receive Peter’s Weekly Newsletter
Eric Ravussin is a world-renowned expert on obesity, metabolism, and aging whose pioneering research has shaped much of what we understand today about energy balance and caloric restriction. In this episode, Eric shares insights from his cutting-edge work on energy expenditure—a critical factor in understanding how our bodies regulate weight and appetite. He discusses methods for measuring energy output, energy balance, food intake, and appetite regulation, and explores key studies on macronutrient manipulation. Eric then delves into the CALERIE study on caloric restriction, highlighting insights related to biomarkers of both primary and secondary aging. The conversation also covers the potential of GLP-1 agonists to replicate these effects and looks ahead to how AI and technology could transform metabolic research in the coming years.
We discuss:
- Eric’s background and current work metabolism and measuring energy expenditure [3:00];
- The science behind metabolic chambers for measuring energy expenditure, and the complexities of indirect and direct calorimetry [8:00];
- The body's regulatory systems for maintaining energy balance and the primary influence of energy intake on body weight [18:30];
- The epidemic of obesity and a discussion of resting metabolic rate [24:45];
- The impact of exercise, appetite, gut hormones, and eating patterns on weight regulation [28:45];
- Experiments looking at how macronutrient composition affects energy expenditure [38:45];
- The challenges of studying diet in real-life settings, the potential of personalized nutrition, and how public health policy could play a role in guiding nutritional habits [51:00];
- The importance of protein in the diet, the limitations of dietary data collection, and how AI could potentially transform nutrition science [1:08:15];
- How Eric’s interest in caloric restriction (CR) began with Biosphere 2, metabolic efficiency's role in aging, and goals of the CALERIE study [1:15:15];
- The CALERIE study: exploring the real-world impact of caloric restriction [1:28:00];
- Notable findings from the CALERIE study after two years: sustained weight loss, participant retention, and more [1:40:00];
- The effect of caloric restriction on the hallmarks of aging [1:47:00];
- The challenge of applying CR to the general population, the potential of drugs and exercise to mimic the effects of CR [1:55:45];
- Upcoming study comparing caloric restriction to time-restricting eating, and Peter’s takeaways from the discussion [2:02:45]; and
- More.
Connect With Peter on Twitter, Instagram, Facebook and YouTube
More shows like The Peter Attia Drive
View all
Boundless Life
5,003 Listeners
The Human Upgrade: Biohacking for Longevity & Performance
7,213 Listeners
The Rich Roll Podcast
11,852 Listeners
FoundMyFitness
5,340 Listeners
High Intensity Health with Mike Mutzel, MS
1,229 Listeners
Well Beyond 40
1,095 Listeners
The Ready State Podcast
500 Listeners
The Proof with Simon Hill
2,603 Listeners
The Genius Life
4,831 Listeners
Dhru Purohit Show
3,472 Listeners
The Dr. Hyman Show
9,273 Listeners
Everyday Wellness with Cynthia Thurlow ™
1,208 Listeners
Huberman Lab
28,512 Listeners
Longevity by Design
183 Listeners
The Dr. Gabrielle Lyon Show
1,143 Listeners