Sathiya introduces the topic of "Your Brain On Porn" and mentions that he works on a course about rewiring the brain. He discusses the lack of recognition of porn addiction as a diagnosable condition in the DSM-5 and reference Dr. Gary Wilson's work on the detrimental effects of pornography. The podcast delves into how prolonged porn use alters the brain and the concept of desensitisation, using examples of sensory adaptation. They highlight numerous studies linking porn addiction to escalation of use, tolerance, withdrawal symptoms, sexual problems, lower arousal, and poor mental health. The idea that the brain can be changed in both directions is emphasised, and the hosts share a personal success story of overcoming addiction.