A framework to guide general neurologists in the diagnostic reassessment of people with epilepsy and complex neurological problems of unknown cause is discussed in this podcast.

Dr Tom Hughes, Practical Neurology Associate Editor, is joined by Dr Lina Nashef (King’s College Hospital, London, UK), the corresponding author of the paper “Investigating adults with early-onset epilepsy and intellectual or physical disability”, which also addresses imaging, electroencephalography, genetic studies and metabolic testing.