Joseph Ahn, MD, FACG, co-author of the new ACG Clinical Guideline on management of focal liver lesions talks with AJG Co-Editor Dr. William D. Chey about the epidemiology of focal liver lesions, use of imaging modalities and blood tests as diagnostic tools for this disorder, and treatment recommendations for different types of focal liver lesions, including hepatocellular carcinoma and adenoma, cholangiocarcinoma, hemangioma, nodular regenerative hyperplasia, and cystic liver lesions. (22:44)