In this episode, Dr. Shanmugam discusses “A Randomized, Placebo-controlled Phase 3 Extension Trial of Long-term Safety and Tolerability of Anifrolumab in Active Systemic Lupus Erythematosus”, a three-year long-term study designed to understand the safety of anifrolumab in patients with systemic lupus erythematosus (SLE). This study, which was recently published in “Arthritis & Rheumatology”, represents the longest placebo-controlled clinical trial performed in SLE to date. She is joined by our guest, Dr. Richard Furie, Chief of the Division of Rheumatology at Northwell Health in New York and co-author of the paper. 

In this episode, we welcome the lead author of “Deucravacitinib, a Tyrosine Kinase 2 Inhibitor, in Systemic Lupus Erythematosus: A phase 2, Randomized, Double-Blind, Placebo-Controlled Trial” Dr. Eric Morand of Monash University. The objective of this multicenter clinical trial in lupus (recently published in “Arthritis & Rheumatology”) was to assess the efficacy of deucravacitinib in a phase II trial in adult patients with active lupus. Dr. Morand’s methods, results and ultimate conclusions take center stage of our show today. 

Join us this week as we interview the lead author of “Genicular Nerve Block for Pain Management in Patients with Knee Osteoarthritis: A Randomized Placebo-Controlled Trial”, Dr. Michael Shanahan. Dr. Shanahan’s study, most recently published in “Arthritis & Rheumatology” attempts to determine the efficacy of ultrasound-guided genicular nerve block in managing pain in patients with knee osteoarthritis. Dr. Shanahan discusses his team’s methods, results and conclusions of this paper plus some career advice and insights at the top of the show. 

This week, our guest is Dr. Grace Lo, first author of “Association Between Walking for Exercise and Symptomatic and Structural Progression in Individuals with Knee Osteoarthritis: Data from the Osteoarthritis Initiative Cohort” And Assistant Professor at Baylor College of Medicine. The objective of her study: To assess the relationship between walking for exercise and symptomatic and structural disease progression in individuals with knee OA. In this episode, she shares her methods and results with us as well as some career advice for our young listeners as well as some motivation to get out there and enjoy a nice walk! 

This week on ‘Journals’, Dr. Shanmugam has invited Dr Joann B Sweasy and Dr. Westley Reeves to discuss a paper with an interesting journey, “A Human MSH6 Germline Variant Associated with Systemic Lupus Erythematosus Induces Lupus-Like Disease in Mice“. In this paper, we discover that the science is always telling us something, regardless of where we believe we’re headed and where we ultimately end up. This lupus study has such a story. Join us as our guests explain the study’s objective, the interesting results, what they did to achieve them and their overall conclusion. 

In this week’s episode, Dr. Shanmugam welcomes Dr. Mary Beth Son, the senior author and corresponding author of “Treatment of Multisystem Inflammatory Syndrome in Children: Understanding Differences in Results of Comparative Effectiveness Studies.” This study sought to determine whether the application of different MIS-C definitions and differing disease severity in patients participating in two separate comparative cohorts underlay discrepant results. Dr. Jon Hausmann, pediatric rheumatologist and host of “ACR on Air”, joins Dr. Shanmugam and Dr. Son to add to the significant expertise on this episode, with his own in both clinical pediatric and adult rheumatology. Here, Dr. Hausmann shares further insights on integrating the published literature with pediatric treatment of MIS-C. 

This week we welcome Dr. Jamie Collins, lead author of “Five-Year Structural Changes in the Knee Among Patients With Meniscal Tear and Osteoarthritis: Data From a Randomized Controlled Trial of Arthroscopic Partial Meniscectomy Versus Physical Therapy“. We discuss this study’s methods, statistical results and what all that data indicates about the role of exercise and surgery. Later, Dr. Collins offers advice for non-clinicians working with clinicians and explains what it's like being a mathematician analyzing data in the field of rheumatology and how she came to pursue her own research and write her own grants within the field. 

In this episode, we welcome Dr. Dua and Dr. Bolster to the show, co-first authors of “Virtually Speaking: The impact of a Nationwide Synchronous and Asynchronous Learning Forum.” and discuss the study’s findings along with their educational collaborative initiative Virtual Fellows in Training (VFIT), which includes a compendium of online courses: Virtual Rheumatology Learning Collaborative (ViRL), Virtual Rheumatology Practicum (ViP Adult & ViP Pediatric) and Virtual Rheumatology Teach Lessons (ViTLs). 

In our inaugural episode we welcome Dr Monica Yang, lead author for "Reactogenicity of the Messenger RNA SARS–CoV-2 Vaccines Associated With Immunogenicity in Patients With Autoimmune and Inflammatory Disease" and Dr. Maria Danila the Associate Editor for the manuscript. We discuss some of the findings their COVID19 Vaccine Response in Patients with Autoimmune Disease (COVARiPAD) study found, deeply dive into the data that supports their findings and ask what was involved in putting this manuscript together, which eventually led to its publishing in "Arthritis Care and Research"

The American College of Rheumatology’s newest podcast series featuring interviews, commentary, and analysis on research from our three peer-reviewed journals. Whether it’s an expert analysis of a manuscript or deep dive with an author – our goal is the same – to understand the impact of the science and bring it from the bench to the bedside.