In this episode of the AGA Perspective series, Dr. Gyanprakash Ketwaroo hosts a discussion on the best practices for removing large or complex colon polyps. Joined by Drs. Jeffrey Mosko and Moamen Gabr, the conversation explores the evolution of endoscopic techniques, the importance of careful polyp selection, and the challenges faced in advanced tissue resection. The experts share insights on complications associated with EMR and ESD procedures, emphasizing the need for meticulous technique to ensure patient safety. The episode concludes with reflections on innovations in the field and the future of patient care in gastroenterology.