In this episode of the AGA Perspective series, Dr. Gyanprakash Ketwaroo hosts a discussion on the best practices for removing large or complex colon polyps. Joined by Drs. Jeffrey Mosko and Moamen Gabr, the conversation explores the evolution of endoscopic techniques, the importance of careful polyp selection, and the challenges faced in advanced tissue resection. The experts share insights on complications associated with EMR and ESD procedures, emphasizing the need for meticulous technique to ensure patient safety. In the second half of the episode, Dr. Ira Leeds offers a counterpoint, urging caution when managing polyps in the cecum and rectum, while highlighting the role of minimally invasive surgical approaches.