Things get a little nerdy in this episode, which focuses on the basic science of what makes the inflammasome tick in CAPS, as well as data on the use of interleukin 1 inhibition. Hint: Listen to “The Inflammasome for Dunces” episode first, and this one will make more sense.

• Intro :20
• Recap of Part 1 :33
• Overview of this episode 1:56
• Familial cold autoinflammatory syndrome 3:04
• Muckle-Wells syndrome 6:34
• The two checkpoint problem 8:36
• What do we know about the inhibition of the inflammasome? 11:13
• Back to the trebuchet analogy 11:48

Brought to you by GSK. Considering a treatment change for patients with active SLE? Learn about a treatment option for your patients at treatfortodayandtomorrow.com

• A paper on CARD8 in the setting of CAPS 13:50
• Let’s talk about prostaglandins 15:27
• There are over 100 mutations in CAPS 18:15
• Let’s talk about treatment 18:42
• One caveat 25:41
• That’s CAPS 26:45
• Reach out to me via email and on Twitter 27:03
• Episode recap 27:41

We’d love to hear from you! Send your comments/questions to [email protected]. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum

Brought to you by GSK. Consider the long-term impact of disease activity, flares and corticosteroid use on patients with active SLE. Learn more now at treatfortodayandtomorrow.com.

Disclosure: Brown reports no relevant financial disclosures.

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