Clive Kearon, MD, PhD, and COL Lisa K. Moores, MC, USA, FCCP, join CHEST Evidence-Based Medicine Section Editor, Ian T. Nathanson, MD, FCCP, to review the important updates to the VTE Guidelines. This is the first of the topic updates to CHEST since the move to a "living guidelines" model, where topics will be updated on a rolling basis, not compiled into a single supplement containing all updates.