Drs. Robert Whittington and Guillaume Besch discuss the article “Postoperative Neurocognitive Disorders After Closed-Loop Versus Manual Target Controlled- Infusion of Propofol and Remifentanil in Patients Undergoing Elective Major Noncardiac Surgery: The Randomized Controlled Postoperative Cognitive Dysfunction-Electroencephalographic-Guided Anesthetic Administration Trial.” published in the October 2021 issue of Anesthesia & Analgesia.