Robert J. McCunney, MD, MPH, and David C. Christiani, MD, MPH, FCCP, are interviewed by CHEST Podcast Editor, D. Kyle Hogarth, MD, FCCP, as they discuss the many issues posed by the increasing use of low-dose spriral CT (LDCT) in lung cancer screening. The focus is on McCunney and Li's article in this month's issue of CHEST, comparing 20- to 30-year exposure to LDCT with that of nuclear workers and atomic bomb survivors. The conversation covers many topics, including level of exposure, the problem of false positives, machine calibration, and appropriate candidates for LDCT.